F
Fernando R. Xavier
Researcher at Universidade do Estado de Santa Catarina
Publications - 32
Citations - 430
Fernando R. Xavier is an academic researcher from Universidade do Estado de Santa Catarina. The author has contributed to research in topics: Chemistry & Catalysis. The author has an hindex of 11, co-authored 23 publications receiving 362 citations. Previous affiliations of Fernando R. Xavier include Universidade Federal de Santa Catarina & Wayne State University.
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Journal ArticleDOI
Electronic Structure and Spectro-Structural Correlations of FeIIIZnII Biomimetics for Purple Acid Phosphatases: Relevance to DNA Cleavage and Cytotoxic Activity
Rosely A. Peralta,Adailton J. Bortoluzzi,Bernardo de Souza,Rafael Jovito,Fernando R. Xavier,Ricardo Alexandre Alves de Couto,Annelise Casellato,Faruk Nome,Andrew Dick,Lawrence R. Gahan,Gerhard Schenk,Graeme R. Hanson,Flávia C. S. de Paula,Elene C. Pereira-Maia,Sergio Machado,Patricia Cardoso Severino,Claus Tröger Pich,Tiago Bortolotto,Hernán Terenzi,Eduardo E. Castellano,Ademir Neves,Mark J. Riley +21 more
TL;DR: This study establishes benchmarks against accurate crystallographic structural information using spectroscopic techniques that are not restricted to single crystals and shows that the cytotoxic activity of the biomimetics on leukemia and lung tumoral cells is highest for complexes with electron-donating groups.
Journal ArticleDOI
Unsymmetrical FeIIICoII and GaIIICoII Complexes as Chemical Hydrolases:Biomimetic Models for Purple Acid Phosphatases (PAPs)
Fernando R. Xavier,Ademir Neves,Annelise Casellato,Rosely A. Peralta,Adailton J. Bortoluzzi,Bruno Szpoganicz,Patricia Cardoso Severino,Hernán Terenzi,Zbigniew Tomkowicz,Zbigniew Tomkowicz,Sergei Ostrovsky,Sergei Ostrovsky,Wolfgang Haase,Andrew Ozarowski,J. Krzystek,Joshua Telser,Gerhard Schenk,Lawrence R. Gahan +17 more
TL;DR: Kinetic studies suggest a mechanism in which a terminal M(III)-bound hydroxide is the hydrolysis-initiating nucleophilic catalyst in the novel isostructural Fe(III)Co(II)(BPBPMP)Fe(III)(mu-OAc)(2)M(II) complexes, which show maximum catalytic activity in DNA Hydrolysis near physiological pH.
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New unsymmetric dinuclear Cu(II)Cu(II) complexes and their relevance to copper(II) containing metalloenzymes and DNA cleavage.
Rosely A. Peralta,Ademir Neves,Adailton J. Bortoluzzi,Ademir dos Anjos,Fernando R. Xavier,Bruno Szpoganicz,Hernán Terenzi,Mauricio C. B. De Oliveira,Eduardo E. Castellano,Geraldo R. Friedermann,Antonio S. Mangrich,Miguel A. Novak +11 more
TL;DR: Solution studies in dichloromethane, using UV-Visible spectroscopy and electrochemistry, indicate that under these experimental conditions the first coordination spheres of the Cu(II) centers are maintained as observed in the solid state structures, and that both forms can be brought into equilibrium.
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Facile and efficient aerobic one-pot synthesis of benzimidazoles using Ce(NO3)3·6H2O as promoter
Guilherme M. Martins,Thiago Puccinelli,Rogério A. Gariani,Fernando R. Xavier,Claudio C. Silveira,Samuel R. Mendes +5 more
TL;DR: In this paper, a series of 2-substituted benzimidazoles was synthesized under aerobic conditions, by simply heating 1,2-diaminobenzene and aldehydes in DMF at 80°C, employing Ce(NO 3 ) 3 ·6H 2 O as promoter and atmospheric air as an efficient oxidant.
Journal ArticleDOI
First-transition-metal complexes containing the ligands 6-amino-6-methylperhydro-1,4-diazepine (AAZ) and a new functionalized derivative: can AAZ act as a mimetic ligand for 1,4,7-triazacyclononane?
Rosely A. Peralta,Ademir Neves,Adailton J. Bortoluzzi,Annelise Casellato,Ademir dos Anjos,Alessandra Greatti,Fernando R. Xavier,Bruno Szpoganicz +7 more
TL;DR: The structure and physicochemistry of the [Ni(II)(AAZ)(2)](ClO(4) (1) complex (AAZ = 6-amino-6-methylperhydro-1,4-diazepine), as a system that is able to mimic some important chelate properties of 1,4,7-triazacyclononane, are reported.