F
Fiona Doetsch
Researcher at University of Basel
Publications - 49
Citations - 19157
Fiona Doetsch is an academic researcher from University of Basel. The author has contributed to research in topics: Stem cell & Neural stem cell. The author has an hindex of 34, co-authored 47 publications receiving 17983 citations. Previous affiliations of Fiona Doetsch include Rockefeller University & Columbia University.
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Journal ArticleDOI
Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain
Fiona Doetsch,Isabelle Caillé,Daniel A. Lim,José Manuel García-Verdugo,Arturo Alvarez-Buylla +4 more
TL;DR: It is shown that SVZ astrocytes act as neural stem cells in both the normal and regenerating brain and give rise to cells that grow into multipotent neurospheres in vitro.
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Cellular Composition and Three-Dimensional Organization of the Subventricular Germinal Zone in the Adult Mammalian Brain
TL;DR: The results suggest that chains of migrating neuroblasts in the SVZ may be derived from Type C cells, which had immature ultrastructural characteristics and were nestin-positive but negative to the other markers.
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The transcriptional network for mesenchymal transformation of brain tumours
Maria Stella Carro,Wei Keat Lim,Mariano J. Alvarez,Robert J. Bollo,Xudong Zhao,Evan Y. Snyder,Erik P. Sulman,Sandrine L. Anne,Sandrine L. Anne,Fiona Doetsch,Howard Colman,Anna Lasorella,Kenneth Aldape,Andrea Califano,Antonio Iavarone +14 more
TL;DR: It is shown that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignantglioma.
Journal ArticleDOI
EGF Converts Transit-Amplifying Neurogenic Precursors in the Adult Brain into Multipotent Stem Cells
Fiona Doetsch,Leopoldo Petreanu,Isabelle Caillé,José Manuel García-Verdugo,Arturo Alvarez-Buylla,Arturo Alvarez-Buylla +5 more
TL;DR: It is shown that transit-amplifying C cells retain stem cell competence under the influence of growth factors and are 53-fold enriched for neurosphere generation.
Journal ArticleDOI
A specialized vascular niche for adult neural stem cells.
Masoud Tavazoie,Lieven Van der Veken,Violeta Silva-Vargas,Marjorie Louissaint,Lucrezia Colonna,Bushra Zaidi,José Manuel García-Verdugo,Fiona Doetsch +7 more
TL;DR: The vasculature is a key component of the adult SVZ neural stem cell niche, with SVZ stem cells and transit-amplifying cells uniquely poised to receive spatial cues and regulatory signals from diverse elements of the vascular system.