Igor Paron

TL;DR: A new intensity determination and normalization procedure called MaxLFQ is developed that is fully compatible with any peptide or protein separation prior to LC-MS analysis, which accurately detects the mixing ratio over the entire protein expression range, with greater precision for abundant proteins.

TL;DR: An in-StageTip method for performing sample processing, from cell lysis through elution of purified peptides, in a single, enclosed volume, and observes excellent quantitative reproducibility between replicates.

TL;DR: A concurrent multi-omics study of SARS CoV-2 and SARS-CoV was conducted in this article, where the authors profiled the interactomes of both viruses, as well as their influence on the transcriptome, proteome, ubiquitinome and phosphoproteome of a lung derived human cell line.

TL;DR: The TGF-β pathway, known for its involvement in tissue fibrosis, was specifically dysregulated by Sars-CoV-2 ORF8 and autophagy by SARS-CoVs ORF3, and was identified as a hotspot that can be targeted by existing drugs and it can guide rational design of virus- and host-directed therapies.

TL;DR: The new system - termed Evosep One - analyzes samples in an extremely robust and high throughput manner, without sacrificing in depth proteomics coverage, while maintaining the sensitivity of current nano-flow LC systems.