F
Franck Letournel
Researcher at University of Angers
Publications - 63
Citations - 2156
Franck Letournel is an academic researcher from University of Angers. The author has contributed to research in topics: Medicine & Mitochondrial DNA. The author has an hindex of 18, co-authored 57 publications receiving 1911 citations. Previous affiliations of Franck Letournel include University of Nantes & French Institute of Health and Medical Research.
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Journal ArticleDOI
G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.
Suzanne Lesage,Mathieu Anheim,Franck Letournel,Luc Bousset,Aurélie Honoré,Nelly Rozas,Laura Pieri,Karine Madiona,Alexandra Durr,Ronald Melki,Christophe Verny,Alexis Brice +11 more
TL;DR: A French family with a parkinsonian–pyramidal syndrome harboring a novel heterozygous SNCA mutation is described.
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OPA1 mutations induce mitochondrial DNA instability and optic atrophy plus phenotypes
Patrizia Amati-Bonneau,Maria Lucia Valentino,Pascal Reynier,María Esther Gallardo,Belén Bornstein,Anne Boissiere,Yolanda Campos,Henry Rivera,Jesús González de la Aleja,Rosanna Carroccia,Luisa Iommarini,Pierre Labauge,Dominique Figarella-Branger,Pascale Marcorelles,Alain Furby,Katell Beauvais,Franck Letournel,Rocco Liguori,Chiara La Morgia,Pasquale Montagna,Maria Liguori,Claudia Zanna,Michela Rugolo,Andrea Cossarizza,Bernd Wissinger,Christophe Verny,Robert Schwarzenbacher,Miguel A. Martín,Joaquiotan Arenas,Carmen Ayuso,Rafael Garesse,Guy Lenaers,Dominique Bonneau,Valerio Carelli +33 more
TL;DR: In this paper, mutations in the OPA1 gene can also be responsible for a syndromic form of DOA associated with sensorineural deafness, ataxia, axonal sensory-motor polyneuropathy, chronic progressive external ophthalmoplegia and mitochondrial myopathy.
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Phenotype associated with APP duplication in five families
Lucie Cabrejo,Lucie Guyant-Maréchal,Annie Laquerrière,Martine Vercelletto,François De la Fournière,Catherine Thomas-Antérion,Christophe Verny,Franck Letournel,Florence Pasquier,Anne Vital,Frédéric Checler,Thierry Frebourg,Dominique Campion,Didier Hannequin +13 more
TL;DR: The neuropathological findings in five cases demonstrated Alzheimer's disease and severe CAA lesions that were reminiscent from those reported in brains of Down's syndrome patients.
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Mitochondrial complex I deficiency in GDAP1-related autosomal dominant Charcot-Marie-Tooth disease (CMT2K).
Julien Cassereau,Arnaud Chevrollier,Naïg Gueguen,Marie-Claire Malinge,Franck Letournel,Guillaume Nicolas,Laurence Richard,Marc Ferré,Christophe Verny,Frédéric Dubas,Vincent Procaccio,Patrizia Amati-Bonneau,Dominique Bonneau,Pascal Reynier +13 more
TL;DR: The three CMT2K patients the authors studied carried a novel dominant GDAP1 mutation, C240Y (c.719G > A), which may be involved in energy production and in the control of mitochondrial volume.
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Multicenter Assessment of Immunohistochemical Methods for Pathological Alpha-Synuclein in Sigmoid Colon of Autopsied Parkinson's Disease and Control Subjects.
Thomas G. Beach,Anne Gaëlle Corbillé,Franck Letournel,Jeffrey H. Kordower,Thomas Kremer,David G. Munoz,Anthony Intorcia,Joseph G. Hentz,Charles H. Adler,Lucia I. Sue,Jessica E. Walker,Geidy E. Serrano,Pascal Derkinderen,Pascal Derkinderen +13 more
TL;DR: Submucosa and LTS is present, and when specific staining is defined as being consistent with neuronal morphology, adequately-trained raters may reliably distinguish PD colon from control using suitable IHC methods.