F
Franco Celada
Researcher at University of Genoa
Publications - 98
Citations - 3189
Franco Celada is an academic researcher from University of Genoa. The author has contributed to research in topics: Antigen & Antibody. The author has an hindex of 29, co-authored 98 publications receiving 3135 citations. Previous affiliations of Franco Celada include Sapienza University of Rome & Oak Ridge National Laboratory.
Papers
More filters
Journal ArticleDOI
A computer model of cellular interactions in the immune system
Franco Celada,Philip E. Seiden +1 more
TL;DR: This article presents a model that, they suggest, is rich enough to allow computer experiments to be used as practical adjuncts to the usual biological experiments, at a saving of cost and time.
Journal ArticleDOI
Effect of antigen/antibody ratio on macrophage uptake, processing, and presentation to T cells of antigen complexed with polyclonal antibodies.
TL;DR: An excess of specific polyclonal antibodies hampers proteolytic degradation of antigen in vitro, supporting the view that a similar mechanism may operate within the APC that have internalized immune complexes in extreme antibody excess.
Journal ArticleDOI
Polyspecificity of T cell and B cell receptor recognition
Kai W. Wucherpfennig,Paul M. Allen,Franco Celada,Irun R. Cohen,Rob J. de Boer,K. Christopher Garcia,Byron Goldstein,Ralph J. Greenspan,David A. Hafler,Philip D. Hodgkin,Erik S. Huseby,David C. Krakauer,David Nemazee,Alan S. Perelson,Clemencia Pinilla,Roland K. Strong,Eli E. Sercarz +16 more
TL;DR: It is concluded that polyspecificity is a general, inherent feature of TCR and antibody recognition and the implications of this discovery for lymphocyte biology and disease processes are summarized.
Journal ArticleDOI
A model for simulating cognate recognition and response in the immune system.
Philip E. Seiden,Franco Celada +1 more
TL;DR: A model of the immune system that focuses on the clonotypic cell types and their interactions with other cells, and with antigens and antibodies is constructed, and a generalized cellular automaton implementation of the model is carried out.
Journal ArticleDOI
Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity
Markus Cornberg,Alex T. Chen,Lee A. Wilkinson,Michael A. Brehm,Sung-Kwon Kim,Claudia Calcagno,Dario Ghersi,Roberto Puzone,Franco Celada,Franco Celada,Raymond M. Welsh,Liisa K. Selin +11 more
TL;DR: T cell oligoclonality, including extremes in clonal dominance, may be a consequence of heterologous immunity and lead to viral escape, which has implications for the design of peptide-based vaccines, which might unintentionally prime for skewed TCR responses to cross-reactive epitopes.