F
Françoise Merlin
Researcher at Council on Education for Public Health
Publications - 9
Citations - 1610
Françoise Merlin is an academic researcher from Council on Education for Public Health. The author has contributed to research in topics: Inflammatory bowel disease & Genotype. The author has an hindex of 9, co-authored 9 publications receiving 1578 citations. Previous affiliations of Françoise Merlin include French Institute of Health and Medical Research & Paris Diderot University.
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Journal ArticleDOI
CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease.
Suzanne Lesage,Habib Zouali,Jean-Pierre Cézard,Jean-Frederic Colombel,Jacques Belaiche,Sven Almer,Curt Tysk,Colm O'Morain,Miquel A. Gassull,Vibeke Binder,Yigael Finkel,Robert Modigliani,Corinne Gower-Rousseau,J. Macry,Françoise Merlin,Mathias Chamaillard,Anne-Sophie Jannot,Gilles Thomas,Jean-Pierre Hugot +18 more
TL;DR: The mutational analyses of CARD15 in 453 patients with CD, including 166 sporadic and 287 familial cases, 159 patients with ulcerative colitis (UC), and 103 healthy control subjects provide tools for a DNA-based test of susceptibility and for genetic counseling in inflammatory bowel disease.
Journal ArticleDOI
NOD2/CARD15 does not influence response to infliximab in Crohn's disease
Severine Vermeire,Edouard Louis,Paul Rutgeerts,Martine De Vos,André Van Gossum,Jacques Belaiche,Paul Pescatore,René Fiasse,P. Pelckmans,Robert Vlietinck,Françoise Merlin,Habib Zouali,Gilles Thomas,Jean-Frederic Colombel,Jean-Pierre Hugot +14 more
TL;DR: NOD2/CARD15 was not predictive of treatment outcome with infliximab in Crohn's disease, and multivariate analysis could not identify clinical characteristics that, in combination with NOD1/Card15 mutations, were associated with response to inflIXimab.
Journal ArticleDOI
Nod2 regulates the host response towards microflora by modulating T cell function and epithelial permeability in mouse Peyer's patches
Frédérick Barreau,Chrystèle Madre,Ulrich Meinzer,Dominique Berrebi,Monique Dussaillant,Françoise Merlin,Lars Eckmann,Mickael Karin,Ghislaine Sterkers,Stéphane Bonacorsi,Thécla Lesuffleur,Jean-Pierre Hugot +11 more
TL;DR: It appears that Nod2 modulates the cross-talk between CD4+ T cells and the epithelium recovering PP and that it downregulates the pro-inflammatory effect driven by the ileal microflora, likely by inhibiting the TLR pathways.
Journal ArticleDOI
Significant linkage to spondyloarthropathy on 9q31–34
Corinne Miceli-Richard,Habib Zouali,Roula Said-Nahal,Suzanne Lesage,Françoise Merlin,Claudia de Toma,Hélène Blanché,Mourad Sahbatou,Maxime Dougados,Gilles Thomas,Maxime Breban,Jean-Pierre Hugot,Groupe Français d'Etude Génétique des Spondylarthropathies +12 more
TL;DR: Evidence is provided for the presence of a non-MHC susceptibility locus for SpA mapping to 9q31-34, in the vicinity of marker D9S1776.
Journal ArticleDOI
TNFSF15 polymorphisms are associated with susceptibility to inflammatory bowel disease in a new European Cohort.
Raphaële Thiébaut,S. Kotti,Camille Jung,Françoise Merlin,Jean-Frederic Colombel,Marc Lémann,Sven Almer,Curt Tysk,M. O'Morain,Miquel A. Gassull,Vibeke Binder,Yigael Finkel,Leigh Pascoe,J P Hugot +13 more
TL;DR: This study confirms that TNFSF15 or a closely linked gene is involved in the genetic predisposition to CD and confirms a clinical subgroup of CD patients specifically associated with TN FSF15 haplotype A.