M
Martine De Vos
Researcher at Ghent University Hospital
Publications - 214
Citations - 23120
Martine De Vos is an academic researcher from Ghent University Hospital. The author has contributed to research in topics: Inflammatory bowel disease & Infliximab. The author has an hindex of 55, co-authored 204 publications receiving 20698 citations. Previous affiliations of Martine De Vos include Ghent University.
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Journal ArticleDOI
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Luke Jostins,Stephan Ripke,Rinse K. Weersma,Richard H. Duerr,Dermot P.B. McGovern,Ken Y. Hui,James Lee,L. Philip Schumm,Yashoda Sharma,Carl A. Anderson,Jonah Essers,Mitja Mitrovic,Kaida Ning,Isabelle Cleynen,Emilie Theatre,Sarah L. Spain,Soumya Raychaudhuri,Philippe Goyette,Zhi Wei,Clara Abraham,Jean-Paul Achkar,Tariq Ahmad,Leila Amininejad,Ashwin N. Ananthakrishnan,Vibeke Andersen,Jane M. Andrews,Leonard Baidoo,Tobias Balschun,Peter A. Bampton,Alain Bitton,Gabrielle Boucher,Stephan Brand,Carsten Büning,Ariella Cohain,Sven Cichon,Mauro D'Amato,Dirk De Jong,Kathy L Devaney,Marla Dubinsky,Cathryn Edwards,David Ellinghaus,Lynnette R. Ferguson,Denis Franchimont,Karin Fransen,Richard B. Gearry,Michel Georges,Christian Gieger,Jürgen Glas,Talin Haritunians,Ailsa Hart,Christopher J. Hawkey,Matija Hedl,Xinli Hu,Tom H. Karlsen,Limas Kupčinskas,Subra Kugathasan,Anna Latiano,Debby Laukens,Ian C. Lawrance,Charlie W. Lees,Edouard Louis,Gillian Mahy,John C. Mansfield,Angharad R. Morgan,Craig Mowat,William G. Newman,Orazio Palmieri,Cyriel Y. Ponsioen,Uroš Potočnik,Natalie J. Prescott,Miguel Regueiro,Jerome I. Rotter,Richard K Russell,Jeremy D. Sanderson,Miquel Sans,Jack Satsangi,Stefan Schreiber,Lisa A. Simms,Jurgita Sventoraityte,Stephan R. Targan,Kent D. Taylor,Mark Tremelling,Hein W. Verspaget,Martine De Vos,Cisca Wijmenga,David C. Wilson,Juliane Winkelmann,Ramnik J. Xavier,Sebastian Zeissig,Bin Zhang,Clarence K. Zhang,Hongyu Zhao,Mark S. Silverberg,Vito Annese,Hakon Hakonarson,Steven R. Brant,Graham L. Radford-Smith,Christopher G. Mathew,John D. Rioux,Eric E. Schadt,Mark J. Daly,Andre Franke,Miles Parkes,Severine Vermeire,Jeffrey C. Barrett,Judy H. Cho +105 more
TL;DR: A meta-analysis of Crohn’s disease and ulcerative colitis genome-wide association scans is undertaken, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls.
Journal ArticleDOI
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Jeffrey C. Barrett,Sarah Hansoul,Dan L. Nicolae,Judy H. Cho,Richard H. Duerr,John D. Rioux,John D. Rioux,Steven R. Brant,Mark S. Silverberg,Kent D. Taylor,M. Michael Barmada,Alain Bitton,Themistocles Dassopoulos,Lisa W. Datta,Todd Green,Anne M. Griffiths,Emily O. Kistner,Michael T. Murtha,Miguel Regueiro,Jerome I. Rotter,L. Philip Schumm,A. Hillary Steinhart,Stephan R. Targan,Ramnik J. Xavier,Cécile Libioulle,Cynthia Sandor,Mark Lathrop,Jacques Belaiche,Olivier Dewit,Ivo Gut,Simon Heath,Debby Laukens,Myriam Mni,Paul Rutgeerts,André Van Gossum,Diana Zelenika,Denis Franchimont,Jean-Pierre Hugot,Martine De Vos,Severine Vermeire,Edouard Louis,Lon R. Cardon,Carl A. Anderson,Hazel E. Drummond,Elaine R. Nimmo,Tariq Ahmad,Natalie J. Prescott,Clive M. Onnie,Sheila A. Fisher,Jonathan Marchini,Jilur Ghori,Suzannah Bumpstead,Rhian Gwilliam,Mark Tremelling,Panos Deloukas,John C. Mansfield,Derek P. Jewell,Jack Satsangi,Christopher G. Mathew,Miles Parkes,Michel Georges,Mark J. Daly,Mark J. Daly +62 more
TL;DR: The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1, which offer promise for informed therapeutic development.
Journal ArticleDOI
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
Andre Franke,Dermot P.B. McGovern,Jeffrey C. Barrett,Kai Wang,Graham L. Radford-Smith,Tariq Ahmad,Charlie W. Lees,Tobias Balschun,James Lee,Rebecca L. Roberts,Carl A. Anderson,Joshua C. Bis,Suzanne Bumpstead,David Ellinghaus,Eleonora M. Festen,Michel Georges,Todd Green,Talin Haritunians,Luke Jostins,Anna Latiano,Christopher G. Mathew,Grant W. Montgomery,Natalie J. Prescott,Soumya Raychaudhuri,Jerome I. Rotter,Philip Schumm,Yashoda Sharma,Lisa A. Simms,Kent D. Taylor,David C. Whiteman,Cisca Wijmenga,Robert N. Baldassano,Murray L. Barclay,Theodore M. Bayless,Stephan Brand,Carsten Büning,Albert Cohen,Jean Frederick Colombel,Mario Cottone,Laura Stronati,Ted Denson,Martine De Vos,Renata D'Incà,Marla Dubinsky,Cathryn Edwards,Timothy H. Florin,Denis Franchimont,Richard B. Gearry,Jürgen Glas,Jürgen Glas,Jürgen Glas,André Van Gossum,Stephen L. Guthery,Jonas Halfvarson,Hein W. Verspaget,Jean-Pierre Hugot,Amir Karban,Debby Laukens,Ian C. Lawrance,Marc Lémann,Arie Levine,Cécile Libioulle,Edouard Louis,Craig Mowat,William G. Newman,Julián Panés,Anne M. Phillips,Deborah D. Proctor,Miguel Regueiro,Richard K Russell,Paul Rutgeerts,Jeremy D. Sanderson,Miquel Sans,Frank Seibold,A. Hillary Steinhart,Pieter C. F. Stokkers,Leif Törkvist,Gerd A. Kullak-Ublick,David C. Wilson,Thomas D. Walters,Stephan R. Targan,Steven R. Brant,John D. Rioux,Mauro D'Amato,Rinse K. Weersma,Subra Kugathasan,Anne M. Griffiths,John C. Mansfield,Severine Vermeire,Richard H. Duerr,Mark S. Silverberg,Jack Satsangi,Stefan Schreiber,Judy H. Cho,Vito Annese,Hakon Hakonarson,Mark J. Daly,Miles Parkes +97 more
TL;DR: A meta-analysis of six Crohn's disease genome-wide association studies and a series of in silico analyses highlighted particular genes within these loci implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP.
Journal ArticleDOI
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Carl A. Anderson,Gabrielle Boucher,Charlie W. Lees,Andre Franke,Mauro D'Amato,Kent D. Taylor,James Lee,Philippe Goyette,Marcin Imielinski,Anna Latiano,Caroline Lagacé,Regan Scott,Leila Amininejad,Suzannah Bumpstead,Leonard Baidoo,Robert N. Baldassano,Murray L. Barclay,Theodore M. Bayless,Stephan Brand,Carsten Büning,Jean-Frederic Colombel,Lee A. Denson,Martine De Vos,Marla Dubinsky,Cathryn Edwards,David Ellinghaus,Rudolf S N Fehrmann,James A B Floyd,Timothy H. Florin,Denis Franchimont,Lude Franke,Michel Georges,Jürgen Glas,Nicole L. Glazer,Stephen L. Guthery,Talin Haritunians,Nicholas K. Hayward,Jean-Pierre Hugot,Gilles Jobin,Debby Laukens,Ian C. Lawrance,Marc Lémann,Arie Levine,Cécile Libioulle,Edouard Louis,Dermot P.B. McGovern,Monica Milla,Grant W. Montgomery,Katherine I. Morley,Craig Mowat,Aylwin Ng,William G. Newman,Roel A. Ophoff,Laura Papi,Orazio Palmieri,Laurent Peyrin-Biroulet,Julián Panés,Anne M. Phillips,Natalie J. Prescott,Deborah D. Proctor,Rebecca L. Roberts,Richard K Russell,Paul Rutgeerts,Jeremy D. Sanderson,Miquel Sans,Philip Schumm,Frank Seibold,Yashoda Sharma,Lisa A. Simms,Mark Seielstad,Mark Seielstad,A. Hillary Steinhart,Stephan R. Targan,Leonard H. van den Berg,Morten H. Vatn,Hein W. Verspaget,Thomas D. Walters,Cisca Wijmenga,David C. Wilson,Harm-Jan Westra,Ramnik J. Xavier,Zhen Zhen Zhao,Cyriel Y. Ponsioen,Vibeke Andersen,Leif Törkvist,Maria Gazouli,Nicholas P. Anagnou,Tom H. Karlsen,Limas Kupčinskas,Jurgita Sventoraityte,John C. Mansfield,Subra Kugathasan,Mark S. Silverberg,Jonas Halfvarson,Jerome I. Rotter,Christopher G. Mathew,Anne M. Griffiths,Richard B. Gearry,Tariq Ahmad,Steven R. Brant,Mathias Chamaillard,Jack Satsangi,Judy H. Cho,Stefan Schreiber,Mark J. Daly,Jeffrey C. Barrett,Miles Parkes,Vito Annese,Hakon Hakonarson,Graham L. Radford-Smith,Richard H. Duerr,Severine Vermeire,Rinse K. Weersma,John D. Rioux +113 more
TL;DR: A meta-analysis of six ulcerative colitis genome-wide association study datasets found many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1.
Journal ArticleDOI
Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial
Geert R. D'Haens,Filip Baert,Gert Van Assche,Philip Caenepeel,Philippe Vergauwe,Hans Tuynman,Martine De Vos,Sander J. H. van Deventer,Larry Stitt,Allan Donner,Allan Donner,Severine Vermeire,Frank J. Van de Mierop,Jean-Charles R Coche,Janneke van der Woude,Thomas Ochsenkühn,Ad A. van Bodegraven,Philippe Van Hootegem,Guy Lambrecht,Fazia Mana,Paul Rutgeerts,Brian G. Feagan,Brian G. Feagan,Daniel W. Hommes +23 more
TL;DR: Combined immunosuppression was more effective than conventional management for induction of remission and reduction of corticosteroid use in patients who had been recently diagnosed with Crohn's disease.