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Amancio Carnero
Researcher at Spanish National Research Council
Publications - 224
Citations - 11268
Amancio Carnero is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Cancer & Carcinogenesis. The author has an hindex of 48, co-authored 208 publications receiving 9945 citations. Previous affiliations of Amancio Carnero include University of Granada & University of Seville.
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Journal ArticleDOI
The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications.
TL;DR: The data strongly support the view of the PTEN/PI3K/AKT pathway as an important target for drug discovery.
Journal ArticleDOI
A Proinflammatory Cytokine Inhibits P53 Tumor Suppressor Activity
James D. Hudson,Mahmood A. Shoaibi,Roberta Maestro,Amancio Carnero,Gregory J. Hannon,David Beach +5 more
TL;DR: The observation that a proinflammatory cytokine, MIF, is capable of functionally inactivating a tumor suppressor, p53, may provide a link between inflammation and tumorigenesis.
Journal Article
Glycolytic Enzymes Can Modulate Cellular Life Span
Hiroshi Kondoh,Matilde E. Lleonart,Matilde E. Lleonart,Jesús Gil,Jesús Gil,Jing Wang,Paolo Degan,Gordon Peters,Dolores Martinez,Amancio Carnero,David Beach +10 more
TL;DR: An unbiased screen for genes that can immortalize mouse embryonic fibroblasts identified the glycolytic enzyme phosphoglycerate mutase (PGM), which enhances gly colytic flux, allows indefinite proliferation, and renders cells resistant to ras-induced arrest.
Journal ArticleDOI
PTEN, more than the AKT pathway.
TL;DR: AKT is more than a passive bridge toward PTEN tumorigenesis, since its expression not only allows but also enforces and accelerates the tumorigenic process in combination with other oncogenes.
Journal ArticleDOI
Roscovitine Targets, Protein Kinases and Pyridoxal Kinase
Stéphane Bach,Marie Knockaert,Jens Reinhardt,Olivier Lozach,Sophie Schmitt,Blandine Baratte,Marcel Koken,Stephen P. Coburn,Lin Tang,Tao Jiang,Dong-Cai Liang,Hervé Galons,Jean-Francois Dierick,Lorenzo A. Pinna,Flavio Meggio,Frank Totzke,Christoph Schächtele,Andrea S. Lerman,Amancio Carnero,Yongqin Wan,Nathanael S. Gray,Laurent Meijer +21 more
TL;DR: The results show that (R)-roscovitine is rather selective for CDKs, in fact most kinases are not affected, but it binds an unexpected, non-protein kinase target, pyridoxal kinase, the enzyme responsible for phosphorylation and activation of vitamin B6.