R
Rodrigo Naves
Researcher at University of Chile
Publications - 28
Citations - 1304
Rodrigo Naves is an academic researcher from University of Chile. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Multiple sclerosis. The author has an hindex of 13, co-authored 24 publications receiving 1067 citations. Previous affiliations of Rodrigo Naves include Universidad del Desarrollo & University of Alabama at Birmingham.
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Journal ArticleDOI
T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis.
Robert C. Axtell,Brigit A. de Jong,Brigit A. de Jong,Brigit A. de Jong,Katia Boniface,Laura F van der Voort,Roopa Bhat,Patrizia De Sarno,Rodrigo Naves,May H. Han,Franklin L. Zhong,Jim G Castellanos,Robert D. Mair,Athena Christakos,Ilan Kolkowitz,Liat Katz,Joep Killestein,Chris H. Polman,Rene de Waal Malefyt,Lawrence Steinman,Chander Raman +20 more
TL;DR: Congruence in outcome between responses to IFN-β in experimental autoimmune encephalomyelitis (EAE) and relapsing-remitting multiple sclerosis (RRMS) is found and a high IL-17F concentration in the serum of people with RRMS is associated with nonresponsiveness to therapy with IFn-β.
Journal ArticleDOI
Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant
Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Noé Ramírez-Alejo,Zhi Li,Zhi Li,Etienne Patin,Etienne Patin,Geetha Rao,Gaspard Kerner,Gaspard Kerner,Che Kang Lim,Che Kang Lim,Dimitry N. Krementsov,Nicholas Hernandez,Cindy S. Ma,Cindy S. Ma,Qian Zhang,Qian Zhang,Janet Markle,Rubén Martínez-Barricarte,Kathryn Payne,Robert Fisch,Caroline Deswarte,Caroline Deswarte,Joshua Halpern,Matthieu Bouaziz,Matthieu Bouaziz,Jeanette Mulwa,Durga Sivanesan,Durga Sivanesan,Tomi Lazarov,Rodrigo Naves,Patricia García,Yuval Itan,Yuval Itan,Bertrand Boisson,Bertrand Boisson,Bertrand Boisson,Alix Checchi,Alix Checchi,Fabienne Jabot-Hanin,Fabienne Jabot-Hanin,Aurélie Cobat,Aurélie Cobat,Andrea Guennoun,Carolyn C. Jackson,Carolyn C. Jackson,Sevgi Pekcan,Zafer Caliskaner,Jaime Inostroza,Beatriz Tavares Costa-Carvalho,Jose Antonio Tavares de Albuquerque,Humberto García-Ortiz,Lorena Orozco,Tayfun Ozcelik,Ahmed Abid,Ismail Abderahmani Rhorfi,Hicham Souhi,Hicham Naji Amrani,Adil Zegmout,Frederic Geissmann,Stephen W. Michnick,Ingrid Müller-Fleckenstein,Bernhard Fleckenstein,Anne Puel,Anne Puel,Anne Puel,Michael J. Ciancanelli,Nico Marr,Hassan Abolhassani,Hassan Abolhassani,María Elvira Balcells,Antonio Condino-Neto,Alexis Strickler,Katia Abarca,Cory Teuscher,Hans D. Ochs,Ismail Reisli,Esra Hazar Sayar,Jamila El-Baghdadi,Jacinta Bustamante,Lennart Hammarström,Lennart Hammarström,Lennart Hammarström,Stuart G. Tangye,Stuart G. Tangye,Sandra Pellegrini,Sandra Pellegrini,Lluis Quintana-Murci,Lluis Quintana-Murci,Laurent Abel,Laurent Abel,Laurent Abel,Jean-Laurent Casanova +94 more
TL;DR: Homozygosity for the catalytically inactive P1104A missense variant of the TYK2 Janus kinase selectively disrupts the induction of IFN-γ by IL-23 and is a common monogenic etiology of tuberculosis.
Journal ArticleDOI
Stage-Specific Role of Interferon-Gamma in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis.
TL;DR: Findings are fundamental to understand the complex role of IFN-γ in the pathogenesis of these diseases and can provide basis for potential stage-specific therapy for MS targeting IFn-γ-signaling or IFN -γ-producing immune cells.
Journal ArticleDOI
Opposing Roles of Interferon-Gamma on Cells of the Central Nervous System in Autoimmune Neuroinflammation.
TL;DR: The dual role of IFN-γ on CNS-resident cells in EAE is reviewed highlighting its protective functions and the mechanisms proposed.
Journal ArticleDOI
Th1 and Th17 Cells and Associated Cytokines Discriminate among Clinically Isolated Syndrome and Multiple Sclerosis Phenotypes.
Gabriel Arellano,Eric Acuña,Lilian I. Reyes,Payton A. Ottum,Patrizia De Sarno,Luis Villarroel,Ethel Ciampi,Reinaldo Uribe San Martín,Claudia Cárcamo,Rodrigo Naves +9 more
TL;DR: Data showed that CIS and MS phenotypes displayed distinct Th1- and Th17-related cytokines and cell profiles and that these immune parameters discriminated between clinical forms, and might be useful as biomarkers to predict disease progression.