F
Frédéric Picard
Researcher at French Institute of Health and Medical Research
Publications - 20
Citations - 5503
Frédéric Picard is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 11, co-authored 16 publications receiving 5335 citations. Previous affiliations of Frédéric Picard include Friedrich Miescher Institute for Biomedical Research.
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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Sung Hee Um,Francesca Frigerio,Mitsuhiro Watanabe,Frédéric Picard,Manel Joaquin,Melanie Sticker,Stefano Fumagalli,Peter R. Allegrini,Sara C. Kozma,Sara C. Kozma,Johan Auwerx,George Thomas +11 more
TL;DR: It is reported that S6K1-deficient mice are protected against obesity owing to enhanced β-oxidation, however on a high fat diet, levels of glucose and free fatty acids still rise in S6k1- deficient mice, resulting in insulin receptor desensitization.
Journal Article
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. [Erratum: 2004 Sept. 23, v. 431, no. 7007, p. 485.]
Sung Hee Um,Francesca Frigerio,Mitsuhiro Watanabe,Frédéric Picard,Manel Joaquin,Melanie Sticker,Stefano Fumagalli,Peter R. Allegrini,Sara C. Kozma,Johan Auwerx +9 more
TL;DR: In this article, S6K1-deficient mice are protected against obesity owing to enhanced β-oxidation, but on a high fat diet, levels of glucose and free fatty acids still rise in S6k1-dependent mice, resulting in insulin receptor desensitization.
Journal ArticleDOI
Nuclear receptors and the control of metabolism.
TL;DR: Altered signaling by this subset of receptors may cause an imbalance in these homeostatic circuits and contribute to the pathogenesis of common metabolic diseases such as obesity, insulin resistance and type 2 diabetes, hyperlipidemia and atherosclerosis, and gallbladder disease.
Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic b Cells
Laura Bordone,Maria Carla Motta,Frédéric Picard,Ulupi S. Jhala,Javier Apfeld,Thomas McDonagh,Madeleine E. Lemieux,Michael W. McBurney,Erin J. Easlon,Leonard Guarente +9 more
TL;DR: In this article, Sirt1 positively regulates insulin secretion in pancreatic b cells and showed that the up-regulation of UCP2 is associated with a failure of cells to increase ATP levels after glucose stimulation.
Journal ArticleDOI
SRC-1 and TIF2 Control Energy Balance between White and Brown Adipose Tissues
Frédéric Picard,Martine Géhin,Jean-Sébastien Annicotte,Stéphane Rocchi,Marie-France Champy,Bert W. O'Malley,Pierre Chambon,Johan Auwerx +7 more
TL;DR: Results reveal that the relative level of TIF2/SRC-1 can modulate energy metabolism, which may contribute to weight gain on a high-fat diet.