M
Marie-France Champy
Researcher at University of Strasbourg
Publications - 44
Citations - 4334
Marie-France Champy is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Candidate gene & Gene. The author has an hindex of 23, co-authored 39 publications receiving 3832 citations. Previous affiliations of Marie-France Champy include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Journal ArticleDOI
Variations in DNA elucidate molecular networks that cause disease
Yanqing Chen,Jun Zhu,Pek Yee Lum,Xia Yang,Shirly Pinto,Douglas J. MacNeil,Chunsheng Zhang,John Lamb,Stephen W. Edwards,Solveig K. Sieberts,Amy Leonardson,Lawrence W. Castellini,Susanna Wang,Marie-France Champy,Bin Zhang,Valur Emilsson,Sudheer Doss,Anatole Ghazalpour,Steve Horvath,Thomas A. Drake,Aldons J. Lusis,Eric E. Schadt +21 more
TL;DR: Application of this method to liver and adipose gene expression data generated from a segregating mouse population results in the identification of a macrophage-enriched network supported as having a causal relationship with disease traits associated with metabolic syndrome.
Journal ArticleDOI
SRC-1 and TIF2 Control Energy Balance between White and Brown Adipose Tissues
Frédéric Picard,Martine Géhin,Jean-Sébastien Annicotte,Stéphane Rocchi,Marie-France Champy,Bert W. O'Malley,Pierre Chambon,Johan Auwerx +7 more
TL;DR: Results reveal that the relative level of TIF2/SRC-1 can modulate energy metabolism, which may contribute to weight gain on a high-fat diet.
Journal ArticleDOI
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains
Michelle Simon,Simon Greenaway,Jacqueline K. White,Helmut Fuchs,Valerie Gailus-Durner,Sara Wells,Tania Sorg,Kim Wong,Elodie Bedu,Elizabeth J. Cartwright,Romain Dacquin,Sophia Djebali,Jeanne Estabel,Jochen Graw,Neil J. Ingham,Ian J. Jackson,Andreas Lengeling,Silvia Mandillo,Jacqueline Marvel,Hamid Meziane,Frédéric Preitner,Oliver Puk,Michel Roux,David J. Adams,Sarah Atkins,Abdel Ayadi,Lore Becker,Andrew Blake,Debra Brooker,Heather Cater,Marie-France Champy,Roy Combe,Petr Danecek,Armida Di Fenza,Hilary Gates,Anna-Karin Gerdin,Elisabetta Golini,John M. Hancock,Wolfgang Hans,Sabine M. Hölter,Tertius Hough,Pierre Jurdic,Thomas M. Keane,Hugh P. Morgan,Werner Müller,Frauke Neff,George Nicholson,Bastian Pasche,Laura-Anne Roberson,Jan Rozman,Mark Sanderson,Luis Santos,Mohammed Selloum,Carl Shannon,Anne Southwell,Glauco P. Tocchini-Valentini,Valerie E. Vancollie,Henrik Westerberg,Wolfgang Wurst,Min Zi,Binnaz Yalcin,Binnaz Yalcin,Ramiro Ramirez-Solis,Karen P. Steel,Ann-Marie Mallon,Martin Hrabě de Angelis,Yann Herault,Steve D.M. Brown +67 more
TL;DR: Comparison of C57BL/6J and C57bl/6N demonstrates a range of phenotypic differences that have the potential to impact upon penetrance and expressivity of mutational effects in these strains.
Journal ArticleDOI
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.
A. Rodriguez,Angeles Duran,Mohammed Selloum,Marie-France Champy,Francisco J. Diez-Guerra,Juana M. Flores,Manuel Serrano,Johan Auwerx,Maria T. Diaz-Meco,Jorge Moscat +9 more
TL;DR: It is proposed that p62 normally antagonizes basal ERK activity and adipocyte differentiation and that its loss leads to the hyperactivation of ERK that favors adipogenesis and obesity.
Journal ArticleDOI
A Unique PPARγ Ligand with Potent Insulin-Sensitizing yet Weak Adipogenic Activity
Stéphane Rocchi,Frédéric Picard,Joseph Vamecq,Laurent Gelman,Noelle Potier,Denis Zeyer,Laurent Dubuquoy,Pierre Bac,Marie-France Champy,Kelli D. Plunket,Lisa M. Leesnitzer,Steven G. Blanchard,Pierre Desreumaux,Dino Moras,Jean-Paul Renaud,Johan Auwerx +15 more
TL;DR: F-L-Leu improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice, yet it has a lower adipogenic activity, suggesting that it is a selective PPARgamma modulator that activates some (insulin sensitization), but not all (adipogenesis), PPARGamma-signaling pathways.