F
Frederik Damm
Researcher at Humboldt University of Berlin
Publications - 76
Citations - 4353
Frederik Damm is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Mutation & Leukemia. The author has an hindex of 30, co-authored 70 publications receiving 3717 citations. Previous affiliations of Frederik Damm include Hannover Medical School & German Cancer Research Center.
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Journal ArticleDOI
A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation
Damien Roos-Weil,Camille Decaudin,Marine Armand,Véronique Della-Valle,M'Boyba Diop,Hussein Ghamlouch,Virginie Ropars,Cécile Hérate,Diane Lara,Eric Durot,Rima Haddad,Elena Mylonas,Frederik Damm,Françoise Pflumio,Bilyana Stoilova,Marlen Metzner,Olivier Elemento,Philippe Dessen,Valérie Camara-Clayette,François-Loïc Cosset,Els Verhoeyen,Els Verhoeyen,Veronique Leblond,Vincent Ribrag,Pascale Cornillet-Lefebvre,Philippe Rameau,Nabih Azar,Frédéric Charlotte,Pierre Morel,Jean-Baptiste Charbonnier,Paresh Vyas,Thomas Mercher,Said Aoufouchi,Nathalie Droin,Christel Guillouf,Florence Nguyen-Khac,Olivier Bernard +36 more
TL;DR: The demonstration that a somatic point mutation tips the balance of genome-binding pattern provides a mechanistic paradigm for how missense mutations in transcription factor genes may be oncogenic in human tumors.
Sequential combination of azacitidine and lenalidomide in del(5q) higher-risk myelodysplastic syndromes or acute myeloid leukemia: a phase I study
Frederik Damm,Raphael Itzykson,Olivier Kosmider,Nathalie Droin,Aline Renneville,Virginie Chesnais,V. Gelsi-Boyer,S de Botton,Norbert Vey,A Clavert,Eric Delabesse,David Jérémie Birnbaum,Michaela Fontenay,O. Bernard,Eric Solary +14 more
TL;DR: This study aims to demonstrate the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals, not necessarily belonging to the same breeds.
Journal ArticleDOI
Clonal hematopoiesis and its emerging effects on cellular therapies.
Malte von Bonin,Helena Jambor,Raphael Teipel,Friedrich Stölzel,Christian Thiede,Frederik Damm,Frank Kroschinsky,Johannes Schetelig,Triantafyllos Chavakis,Martin Bornhäuser +9 more
TL;DR: In this article, the relevance and complications of clonal hematopoiesis for the treatment of hematologic malignancies with cell therapeutic approaches are reviewed and compared.
Journal ArticleDOI
Single-cell omics: Overview, analysis, and application in biomedical science
Catarina M. Stein,Ralf Weiskirchen,Frederik Damm,Frederik Damm,Paulina M. Strzelecka,Paulina M. Strzelecka +5 more
TL;DR: In this article, the authors briefly describe existing single-cell methods (genomics, transcriptomics, epigenomics, proteomics, and mulitomics), comment on available analysis tools, and give examples of method applications in the biomedical field.
Journal ArticleDOI
A genetically defined signature of responsiveness to erlotinib in early-stage pancreatic cancer patients: Results from the CONKO-005 trial.
Kaja Hoyer,R. Hablesreiter,Yoshikage Inoue,Kenichi Yoshida,Franziska Briest,Friederike Christen,Nobuyuki Kakiuchi,Tetsuichi Yoshizato,Yusuke Shiozawa,Yuichi Shiraishi,Jana Käthe Striefler,Sven Bischoff,Philipp Lohneis,Hein Putter,Olga Blau,U. Keilholz,Lars Bullinger,Uwe Pelzer,Michael Hummel,Hanno Riess,Seishi Ogawa,M. Sinn,Frederik Damm,Frederik Damm +23 more
TL;DR: In this article, the authors identified five biologically distinct patient clusters with different actionable lesions and unravelled a previously unappreciated association of SMAD4 alteration status with erlotinib effectiveness.