F
Friederike Schröter
Researcher at University of Düsseldorf
Publications - 16
Citations - 1357
Friederike Schröter is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Induced pluripotent stem cell & SOX2. The author has an hindex of 10, co-authored 16 publications receiving 1207 citations. Previous affiliations of Friederike Schröter include Charité & Max Delbrück Center for Molecular Medicine.
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Journal ArticleDOI
Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress
Ulrike Seifert,Lukasz P. Bialy,Frédéric Ebstein,Dawadschargal Bech-Otschir,Antje Voigt,Friederike Schröter,Timour Prozorovski,Nicole Lange,Janos Steffen,Melanie Rieger,Ulrike Kuckelkorn,Orhan Aktas,Peter-M. Kloetzel,Elke Krüger +13 more
TL;DR: It is shown that i-proteasomes function to protect cell viability under conditions of IFN-induced oxidative stress, and it is found that the ubiquitylation machinery is concomitantly upregulated in response to IFNs, functioning to target defective ribosomal products (DRiPs) for degradation by i- Proteasome.
Journal ArticleDOI
Sirt1 contributes critically to the redox-dependent fate of neural progenitors
Timour Prozorovski,Ulf Schulze-Topphoff,Robert Glumm,Jan Baumgart,Friederike Schröter,Olaf Ninnemann,Elise Siegert,Ivo Bendix,Oliver Brüstle,Robert Nitsch,Frauke Zipp,Orhan Aktas +11 more
TL;DR: Under oxidative conditions in vitro and in vivo, Sirt1 was upregulated in NPCs, bound to the transcription factor Hes1 and subsequently inhibited pro-neuronal Mash1, and provided evidence for an as yet unknown metabolic master switch that determines the fate of neural progenitors.
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Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.
Ulf Schulze-Topphoff,Alexandre Prat,Timour Prozorovski,Timour Prozorovski,Volker Siffrin,Magdalena Paterka,Josephine Herz,Ivo Bendix,Igal Ifergan,Ines Schadock,Marcelo A. Mori,Jack van Horssen,Friederike Schröter,Friederike Schröter,Alina Smorodchenko,May H. Han,Michael Bader,Lawrence Steinman,Orhan Aktas,Orhan Aktas,Frauke Zipp +20 more
TL;DR: Results suggest that the kallikrein-kinin system is involved in the regulation of CNS inflammation, limiting encephalitogenic T lymphocyte infiltration into the CNS, and provide evidence that Bdkrb1 could be a new target for the treatment of chronic inflammatory diseases such as multiple sclerosis.
Journal ArticleDOI
Dual roles of the adenosine A2a receptor in autoimmune neuroinflammation.
Jens Ingwersen,Britta Wingerath,Jonas Graf,Klaudia Lepka,M. Hofrichter,Friederike Schröter,F. Wedekind,A. Bauer,J. Schrader,H.-P. Hartung,Timour Prozorovski,Orhan Aktas +11 more
TL;DR: An upregulation of A2aR in the central nervous system (CNS) in EAE is found, predominantly detected on T cells and macrophages/microglia within the inflamed tissue.
Journal ArticleDOI
Comparative performance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro.
Maxi Hofrichter,Laura Nimtz,Julia Tigges,Yaschar Kabiri,Friederike Schröter,Brigitte Royer-Pokora,Barbara Hildebrandt,Martin Schmuck,Alexey Epanchintsev,Stephan Theiss,James Adjaye,Jean-Marc Egly,Jean Krutmann,Ellen Fritsche +13 more
TL;DR: In this paper, the authors compared two human induced pluripotent stem cells (hiPSC) neural induction protocols resulting in 3D neurospheres: one using noggin and one cultivating cells in neural induction medium (NIM).