F
Fumihiko Matsuda
Researcher at Kyoto University
Publications - 454
Citations - 28863
Fumihiko Matsuda is an academic researcher from Kyoto University. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 69, co-authored 414 publications receiving 24471 citations. Previous affiliations of Fumihiko Matsuda include Massachusetts Institute of Technology & Kanazawa University.
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Journal ArticleDOI
Single-nucleotide polymorphisms in the promoter region of matrix metalloproteinase-1, -2, and -3 in Japanese with high myopia.
Hideo Nakanishi,Hisako Hayashi,Ryo Yamada,Kenji Yamashiro,Isao Nakata,Noriaki Shimada,Kyoko Ohno-Matsui,Manabu Mochizuki,Mineo Ozaki,Shin Yoshitake,Shoji Kuriyama,Masaaki Saito,Tomohiro Iida,Keitaro Matsuo,Fumihiko Matsuda,Nagahisa Yoshimura +15 more
TL;DR: The four functional SNPs in the MMP1, -2, and -3 promoter regions do not play critical roles in the development of high myopia in the Japanese population.
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Association of elastin gene polymorphism to age-related macular degeneration and polypoidal choroidal vasculopathy.
Kenji Yamashiro,Keisuke Mori,Isao Nakata,Takashi Tsuchihashi,Kuniko Horie-Inoue,Hideo Nakanishi,Akitaka Tsujikawa,Masaaki Saito,Tomohiro Iida,Ryo Yamada,Fumihiko Matsuda,Satoshi Inoue,Takuya Awata,Shin Yoneya,Nagahisa Yoshimura +14 more
TL;DR: ELN is associated with AMD in Japanese and the findings suggest that ELN is a susceptibility gene for tAMD but not for PCV, which is opposite to that reported in a previous study that elastin gene is the susceptibility gene in PCV but notfor tAMD.
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Absence of association between COL1A1 polymorphisms and high myopia in the Japanese population.
Hideo Nakanishi,Ryo Yamada,Ryo Yamada,Norimoto Gotoh,Hisako Hayashi,Atsushi Otani,Akitaka Tsujikawa,Kenji Yamashiro,Noriaki Shimada,Kyoko Ohno-Matsui,Manabu Mochizuki,Masaaki Saito,Kuniharu Saito,Tomohiro Iida,Fumihiko Matsuda,Nagahisa Yoshimura +15 more
TL;DR: This study did not replicate the previously reported positive association between COL1A1 and high myopia in the Japanese population, and thus the genetic risk associated with this gene, if any, is weaker than originally reported.
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Generation of a transgenic animal model of hyperthyroid Graves' disease.
Misa Kim-Saijo,Takashi Akamizu,Koichi Ikuta,Yasuhiko Iida,Katsuyuki Ohmori,Kazumi Matsubara,Yoichi Matsuda,Misao Suzuki,Fumihiko Matsuda,Kazuwa Nakao +9 more
TL;DR: Estimation of the human TSAb in mice resulted in various manifestations of hyperthyroidism including increased free thyroxine levels with concomitantly decreased TSH levels, increased thyroid uptake of technetium pertechnetate, hyperthermia and thyroid hyperplasia.
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Isolation of Epstein-Barr-Virus-Transformed Lymphocytes Producing IgG Class Monoclonal Antibodies Using a Magnetic Cell Separator (MACS): Preparation of Thyroid-Stimulating IgG Antibodies from Patients with Graves′ Disease
TL;DR: Four independent B cell clones producing IgG class monoclonal thyroid-stimulating antibodies (TSAb) from three patients with Graves' disease were obtained, suggesting independence of TSAb-producing lymphocytes from those producing TBII.