K
Kenji Yamashiro
Researcher at Kyoto University
Publications - 231
Citations - 10584
Kenji Yamashiro is an academic researcher from Kyoto University. The author has contributed to research in topics: Macular degeneration & Visual acuity. The author has an hindex of 53, co-authored 211 publications receiving 9256 citations. Previous affiliations of Kenji Yamashiro include Massachusetts Eye and Ear Infirmary & Kagawa University.
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Journal ArticleDOI
Genetic variants near TIMP3 and high-density lipoprotein–associated loci influence susceptibility to age-related macular degeneration
Wei Chen,Dwight Stambolian,Albert O. Edwards,Kari Branham,Mohammad Othman,Johanna Jakobsdottir,Nirubol Tosakulwong,Margaret A. Pericak-Vance,Peter A. Campochiaro,Michael L. Klein,Perciliz L. Tan,Yvette P. Conley,Atsuhiro Kanda,Laura J. Kopplin,Yanming Li,Katherine J. Augustaitis,Athanasios J. Karoukis,William K. Scott,Anita Agarwal,Jaclyn L. Kovach,Stephen G. Schwartz,Eric A. Postel,Matthew Brooks,Keith H. Baratz,William L. Brown,Alexander J. Brucker,Anton Orlin,Gary C. Brown,Allen C. Ho,Carl D. Regillo,Larry A. Donoso,Lifeng Tian,Brian Kaderli,Dexter Hadley,Stephanie A. Hagstrom,Stephanie A. Hagstrom,Neal S. Peachey,Neal S. Peachey,Neal S. Peachey,Ronald Klein,Barbara E.K. Klein,Norimoto Gotoh,Kenji Yamashiro,Frederick L. Ferris,Jesen Fagerness,Robyn Reynolds,Lindsay A. Farrer,Ivana K. Kim,Joan W. Miller,Marta Corton,Angel Carracedo,Manuel Sánchez-Salorio,Elizabeth W. Pugh,Kimberly F. Doheny,Maria Brion,Margaret M. DeAngelis,Daniel E. Weeks,Donald J. Zack,Emily Y. Chew,John R. Heckenlively,Nagahisa Yoshimura,Sudha K. Iyengar,Peter J. Francis,Nicholas Katsanis,Johanna M. Seddon,Jonathan L. Haines,Michael B. Gorin,Gonçalo R. Abecasis,Anand Swaroop,Anand Swaroop +69 more
TL;DR: A genome-wide association scan for age-related macular degeneration (AMD) showed that 329 of 331 individuals with the highest-risk genotypes were cases, and 85% of these had advanced AMD, consistent with the hypothesis that HDL metabolism is associated with AMD pathogenesis.
Journal ArticleDOI
VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization.
Susumu Ishida,Tomohiko Usui,Tomohiko Usui,Kenji Yamashiro,Kenji Yamashiro,Yuichi Kaji,Yuichi Kaji,Shiro Amano,Yuichiro Ogura,Tetsuo Hida,Yoshihisa Oguchi,Jayakrishna Ambati,Joan W. Miller,Evangelos S. Gragoudas,Yin-Shan Ng,Patricia A. D'Amore,David T. Shima,Anthony P. Adamis +17 more
TL;DR: During pathological neovascularization, VEGF164 selectively induces inflammation and cellular immunity, which provide positive and negative angiogenic regulation, respectively, and new therapeutic approaches for selectively targeting pathological, but not physiological, retinal neov vascularization are outlined.
Journal ArticleDOI
VEGF164 is proinflammatory in the diabetic retina.
Susumu Ishida,Tomohiko Usui,Tomohiko Usui,Kenji Yamashiro,Kenji Yamashiro,Yuichi Kaji,Yuichi Kaji,Ednan Ahmed,Karen G. Carrasquillo,Shiro Amano,Tetsuo Hida,Yoshihisa Oguchi,Anthony P. Adamis +12 more
TL;DR: The inhibition of diabetic retinal leukostasis and BRB breakdown with EYE001 in early and established diabetes indicates that VEGF(164) is an important isoform in the pathogenesis of early diabetic retinopathy.
Journal ArticleDOI
Macular choroidal thickness and volume in normal subjects measured by swept-source optical coherence tomography.
Masaya Hirata,Akitaka Tsujikawa,Akiko Matsumoto,Akiko Matsumoto,Masanori Hangai,Sotaro Ooto,Kenji Yamashiro,Masahiro Akiba,Nagahisa Yoshimura +8 more
TL;DR: SS-OCT at the 1-μm wavelength region allowed visualization of the fine structure of the choroid as well as that of the retina, and provides macular choroidal thickness maps and allows one to evaluate the chiroidal thickness more accurately.
Journal ArticleDOI
Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease.
Susumu Ishida,Kenji Yamashiro,Kenji Yamashiro,Tomohiko Usui,Tomohiko Usui,Yuichi Kaji,Yuichi Kaji,Yuichiro Ogura,Tetsuo Hida,Yoshihito Honda,Yoshihisa Oguchi,Anthony P. Adamis +11 more
TL;DR: It is shown that leukocytes prune the retinal vasculature during normal development and obliterate it in disease, and these pathways may prove useful in the treatment of retinal ischemia, a leading cause of vision loss and blindness.