G
Gabrielle S. Sellick
Researcher at Institute of Cancer Research
Publications - 53
Citations - 3951
Gabrielle S. Sellick is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Chronic lymphocytic leukemia & Single-nucleotide polymorphism. The author has an hindex of 28, co-authored 53 publications receiving 3817 citations. Previous affiliations of Gabrielle S. Sellick include Bristol Royal Hospital for Children.
Papers
More filters
Journal ArticleDOI
A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21.
Ian Tomlinson,Ian Tomlinson,Emily L. Webb,Luis G. Carvajal-Carmona,Peter Broderick,Zoe Kemp,Sarah L. Spain,Steven Penegar,Ian Chandler,Maggie Gorman,Wendy Wood,Ella Barclay,Steven J. Lubbe,Lynn Martin,Gabrielle S. Sellick,Emma Jaeger,Richard A. Hubner,Ruth Wild,Andrew Rowan,Sarah Fielding,Kimberley Howarth,Andrew Silver,Wendy Atkin,Kenneth Muir,Richard F A Logan,David J. Kerr,Elaine C. Johnstone,Oliver M. Sieber,Richard Gray,Huw Thomas,Julian Peto,Jean-Baptiste Cazier,Richard S. Houlston +32 more
TL;DR: These data show that common, low-penetrance susceptibility alleles predispose to colorectal neoplasia, and suggest that susceptibility to CRC is mediated through development of adenomas.
Journal ArticleDOI
A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
Peter Broderick,Luis G. Carvajal-Carmona,Luis G. Carvajal-Carmona,Alan M. Pittman,Emily L. Webb,Kimberley Howarth,Andrew Rowan,Steven J. Lubbe,Sarah L. Spain,Kate Sullivan,Sarah Fielding,Emma Jaeger,Jayaram Vijayakrishnan,Zoe Kemp,Maggie Gorman,Ian Chandler,Elli Papaemmanuil,Steven Penegar,Wendy Wood,Gabrielle S. Sellick,Mobshra Qureshi,Ana Teixeira,Enric Domingo,Ella Barclay,Lynn Martin,Lynn Martin,Oliver M. Sieber,David J. Kerr,Richard Gray,Julian Peto,Jean-Baptiste Cazier,Ian Tomlinson,Ian Tomlinson,Richard S. Houlston +33 more
TL;DR: Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (Ptrend = 1.0 × 10−12), and three SNPs in SMAD7 (involved in TGF-β and Wnt signaling) associated with CRC were identified.
Journal ArticleDOI
Mutations in PTF1A cause pancreatic and cerebellar agenesis.
Gabrielle S. Sellick,Karen Barker,Irene Stolte-Dijkstra,Christina M. Fleischmann,Richard J. Coleman,Christine Garrett,Anna L. Gloyn,Emma L. Edghill,Andrew T. Hattersley,Peter K. Wellauer,Graham Goodwin,Richard S. Houlston +11 more
TL;DR: Reporter-gene studies using a minimal PTF1A deletion mutant indicate that the deleted region defines a new domain that is crucial for the function of this protein.
Journal ArticleDOI
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia
Maria Chiara Di Bernardo,Dalemari Crowther-Swanepoel,Peter Broderick,Emily L. Webb,Gabrielle S. Sellick,Ruth Wild,Kate Sullivan,Jayaram Vijayakrishnan,Yufei Wang,Alan M. Pittman,Nicola J. Sunter,Andrew G. Hall,Martin J. S. Dyer,Estella Matutes,Claire Dearden,Tryfonia Mainou-Fowler,Graham Jackson,Geoffrey Summerfield,Robert J. Harris,Andrew R. Pettitt,Peter Hillmen,David Allsup,James R. Bailey,Guy Pratt,Chris Pepper,Christopher Fegan,James M. Allan,Daniel Catovsky,Richard S. Houlston +28 more
TL;DR: These data provide the first evidence for the existence of common, low-penetrance susceptibility to a hematological malignancy and new insights into disease causation in CLL.
Journal ArticleDOI
Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency.
Antonio Almeida,Yoshiko Murakami,D.M. Layton,Peter Hillmen,Gabrielle S. Sellick,Yusuke Maeda,Stephen J. Richards,Steven Patterson,Ioannis Kotsianidis,L Mollica,Darrell H. G. Crawford,A. Baker,Michael A. J. Ferguson,Irene Roberts,Richard S. Houlston,Taroh Kinoshita,Anastasios Karadimitris +16 more
TL;DR: It is shown that biosynthesis of GPI is essential to maintain homeostasis of blood coagulation and neurological function and a point mutation at position −270 from the start codon of PIGM, a mannosyltransferase-encoding gene, disrupts binding of the transcription factor Sp1 to its cognate promoter motif.