I
Ian Chandler
Researcher at Royal Devon and Exeter Hospital
Publications - 27
Citations - 3767
Ian Chandler is an academic researcher from Royal Devon and Exeter Hospital. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 21, co-authored 27 publications receiving 3637 citations. Previous affiliations of Ian Chandler include Institute of Cancer Research.
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Journal ArticleDOI
A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21.
Ian Tomlinson,Ian Tomlinson,Emily L. Webb,Luis G. Carvajal-Carmona,Peter Broderick,Zoe Kemp,Sarah L. Spain,Steven Penegar,Ian Chandler,Maggie Gorman,Wendy Wood,Ella Barclay,Steven J. Lubbe,Lynn Martin,Gabrielle S. Sellick,Emma Jaeger,Richard A. Hubner,Ruth Wild,Andrew Rowan,Sarah Fielding,Kimberley Howarth,Andrew Silver,Wendy Atkin,Kenneth Muir,Richard F A Logan,David J. Kerr,Elaine C. Johnstone,Oliver M. Sieber,Richard Gray,Huw Thomas,Julian Peto,Jean-Baptiste Cazier,Richard S. Houlston +32 more
TL;DR: These data show that common, low-penetrance susceptibility alleles predispose to colorectal neoplasia, and suggest that susceptibility to CRC is mediated through development of adenomas.
Journal ArticleDOI
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
Richard S. Houlston,Emily L. Webb,Peter Broderick,Alan M. Pittman,Maria Chiara Di Bernardo,Steven J. Lubbe,Ian Chandler,Jayaram Vijayakrishnan,Kate Sullivan,Steven Penegar,Luis G. Carvajal-Carmona,Kimberley Howarth,Emma Jaeger,Sarah L. Spain,Axel Walther,Ella Barclay,Lynn Martin,Maggie Gorman,Enric Domingo,Ana Teixeira,David J. Kerr,Jean-Baptiste Cazier,Iina Niittymäki,Sari Tuupanen,Auli Karhu,Lauri A. Aaltonen,Ian Tomlinson,Susan M. Farrington,Albert Tenesa,James Prendergast,Rebecca A. Barnetson,Roseanne Cetnarskyj,Mary Porteous,Paul D.P. Pharoah,Thibaud Koessler,Jochen Hampe,Stephan Buch,Clemens Schafmayer,Jürgen Tepel,Stefan Schreiber,Henry Völzke,Jenny Chang-Claude,Michael Hoffmeister,Hermann Brenner,Brent W. Zanke,Alexandre Montpetit,Thomas J. Hudson,Thomas J. Hudson,Thomas J. Hudson,Steven Gallinger,Steven Gallinger,Harry Campbell,Malcolm G. Dunlop +52 more
TL;DR: Four previously unreported CRC risk loci are identified at 14q22.2, highlighting the value of large sample series for discovery and follow-up of genetic variants contributing to the etiology of CRC.
Journal ArticleDOI
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
Ian Tomlinson,Emily L. Webb,Luis G. Carvajal-Carmona,Peter Broderick,Kimberley Howarth,Alan M. Pittman,Sarah L. Spain,Steven J. Lubbe,Axel Walther,Kate Sullivan,Emma Jaeger,Sarah Fielding,Andrew Rowan,Jayaram Vijayakrishnan,Enric Domingo,Ian Chandler,Zoe Kemp,Mobshra Qureshi,Susan M. Farrington,Albert Tenesa,James G. D. Prendergast,Rebecca A. Barnetson,Steven Penegar,Ella Barclay,Wendy Wood,Lynn Martin,Lynn Martin,Lynn Martin,Maggie Gorman,Huw Thomas,Julian Peto,D. Timothy Bishop,Richard Gray,Eamonn R. Maher,Anneke Lucassen,David J. Kerr,D. Gareth Evans,Clemens Schafmayer,Stephan Buch,Henry Völzke,Jochen Hampe,Stefan Schreiber,Ulrich John,Thibaud Koessler,Paul D.P. Pharoah,Tom van Wezel,Hans Morreau,Juul T. Wijnen,John L. Hopper,Melissa C. Southey,Graham G. Giles,Graham G. Giles,Gianluca Severi,Sergi Castellví-Bel,Clara Ruiz-Ponte,Angel Carracedo,Antoni Castells,Asta Försti,Asta Försti,Kari Hemminki,Kari Hemminki,Pavel Vodicka,Alessio Naccarati,Lara Lipton,Judy W. C. Ho,King Yip Cheng,Pak C. Sham,John M. Luk,José A. G. Agúndez,José M. Ladero,Miguel de la Hoya,Trinidad Caldés,Iina Niittymäki,Sari Tuupanen,Auli Karhu,Lauri A. Aaltonen,Jean-Baptiste Cazier,Harry Campbell,Malcolm G. Dunlop,Richard S. Houlston +79 more
TL;DR: Genetic data provide further evidence for the 'common-disease common-variant' model of CRC predisposition and identify two previously unreported associations.
Journal ArticleDOI
A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
Peter Broderick,Luis G. Carvajal-Carmona,Luis G. Carvajal-Carmona,Alan M. Pittman,Emily L. Webb,Kimberley Howarth,Andrew Rowan,Steven J. Lubbe,Sarah L. Spain,Kate Sullivan,Sarah Fielding,Emma Jaeger,Jayaram Vijayakrishnan,Zoe Kemp,Maggie Gorman,Ian Chandler,Elli Papaemmanuil,Steven Penegar,Wendy Wood,Gabrielle S. Sellick,Mobshra Qureshi,Ana Teixeira,Enric Domingo,Ella Barclay,Lynn Martin,Lynn Martin,Oliver M. Sieber,David J. Kerr,Richard Gray,Julian Peto,Jean-Baptiste Cazier,Ian Tomlinson,Ian Tomlinson,Richard S. Houlston +33 more
TL;DR: Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (Ptrend = 1.0 × 10−12), and three SNPs in SMAD7 (involved in TGF-β and Wnt signaling) associated with CRC were identified.
Journal ArticleDOI
Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk
Emma Jaeger,Emily L. Webb,Kimberley Howarth,Luis G. Carvajal-Carmona,Andrew Rowan,Peter Broderick,Axel Walther,Sarah L. Spain,Alan M. Pittman,Zoe Kemp,Kate Sullivan,Karl Heinimann,Steven J. Lubbe,Enric Domingo,Ella Barclay,Lynn Martin,Maggie Gorman,Ian Chandler,Jayaram Vijayakrishnan,Wendy Wood,Elli Papaemmanuil,Steven Penegar,Mobshra Qureshi,Susan M. Farrington,Albert Tenesa,Jean-Baptiste Cazier,David J. Kerr,Richard Gray,Julian Peto,Malcolm G. Dunlop,Harry Campbell,Huw Thomas,Richard S. Houlston,Ian Tomlinson +33 more
TL;DR: In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk and it was hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRCrisk in the general population.