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Alan M. Pittman
Researcher at UCL Institute of Neurology
Publications - 103
Citations - 9877
Alan M. Pittman is an academic researcher from UCL Institute of Neurology. The author has contributed to research in topics: Genome-wide association study & Progressive supranuclear palsy. The author has an hindex of 43, co-authored 95 publications receiving 8852 citations. Previous affiliations of Alan M. Pittman include University College London.
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Journal ArticleDOI
Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism.
David R. Williams,Rohan de Silva,Dominic C. Paviour,Alan M. Pittman,Hilary Watt,Linda Kilford,Janice L. Holton,Tamas Revesz,Andrew J. Lees +8 more
TL;DR: It is proposed that PSP-P represents a second discrete clinical phenotype that needs to be clinically distinguished from classical PSP (RS), and the different tau isoform deposition in the basal pons suggests that this may ultimately prove to be a discrete nosological entity.
Journal ArticleDOI
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
Richard S. Houlston,Emily L. Webb,Peter Broderick,Alan M. Pittman,Maria Chiara Di Bernardo,Steven J. Lubbe,Ian Chandler,Jayaram Vijayakrishnan,Kate Sullivan,Steven Penegar,Luis G. Carvajal-Carmona,Kimberley Howarth,Emma Jaeger,Sarah L. Spain,Axel Walther,Ella Barclay,Lynn Martin,Maggie Gorman,Enric Domingo,Ana Teixeira,David J. Kerr,Jean-Baptiste Cazier,Iina Niittymäki,Sari Tuupanen,Auli Karhu,Lauri A. Aaltonen,Ian Tomlinson,Susan M. Farrington,Albert Tenesa,James Prendergast,Rebecca A. Barnetson,Roseanne Cetnarskyj,Mary Porteous,Paul D.P. Pharoah,Thibaud Koessler,Jochen Hampe,Stephan Buch,Clemens Schafmayer,Jürgen Tepel,Stefan Schreiber,Henry Völzke,Jenny Chang-Claude,Michael Hoffmeister,Hermann Brenner,Brent W. Zanke,Alexandre Montpetit,Thomas J. Hudson,Thomas J. Hudson,Thomas J. Hudson,Steven Gallinger,Steven Gallinger,Harry Campbell,Malcolm G. Dunlop +52 more
TL;DR: Four previously unreported CRC risk loci are identified at 14q22.2, highlighting the value of large sample series for discovery and follow-up of genetic variants contributing to the etiology of CRC.
Journal ArticleDOI
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
Ian Tomlinson,Emily L. Webb,Luis G. Carvajal-Carmona,Peter Broderick,Kimberley Howarth,Alan M. Pittman,Sarah L. Spain,Steven J. Lubbe,Axel Walther,Kate Sullivan,Emma Jaeger,Sarah Fielding,Andrew Rowan,Jayaram Vijayakrishnan,Enric Domingo,Ian Chandler,Zoe Kemp,Mobshra Qureshi,Susan M. Farrington,Albert Tenesa,James G. D. Prendergast,Rebecca A. Barnetson,Steven Penegar,Ella Barclay,Wendy Wood,Lynn Martin,Lynn Martin,Lynn Martin,Maggie Gorman,Huw Thomas,Julian Peto,D. Timothy Bishop,Richard Gray,Eamonn R. Maher,Anneke Lucassen,David J. Kerr,D. Gareth Evans,Clemens Schafmayer,Stephan Buch,Henry Völzke,Jochen Hampe,Stefan Schreiber,Ulrich John,Thibaud Koessler,Paul D.P. Pharoah,Tom van Wezel,Hans Morreau,Juul T. Wijnen,John L. Hopper,Melissa C. Southey,Graham G. Giles,Graham G. Giles,Gianluca Severi,Sergi Castellví-Bel,Clara Ruiz-Ponte,Angel Carracedo,Antoni Castells,Asta Försti,Asta Försti,Kari Hemminki,Kari Hemminki,Pavel Vodicka,Alessio Naccarati,Lara Lipton,Judy W. C. Ho,King Yip Cheng,Pak C. Sham,John M. Luk,José A. G. Agúndez,José M. Ladero,Miguel de la Hoya,Trinidad Caldés,Iina Niittymäki,Sari Tuupanen,Auli Karhu,Lauri A. Aaltonen,Jean-Baptiste Cazier,Harry Campbell,Malcolm G. Dunlop,Richard S. Houlston +79 more
TL;DR: Genetic data provide further evidence for the 'common-disease common-variant' model of CRC predisposition and identify two previously unreported associations.
Journal ArticleDOI
A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
Peter Broderick,Luis G. Carvajal-Carmona,Luis G. Carvajal-Carmona,Alan M. Pittman,Emily L. Webb,Kimberley Howarth,Andrew Rowan,Steven J. Lubbe,Sarah L. Spain,Kate Sullivan,Sarah Fielding,Emma Jaeger,Jayaram Vijayakrishnan,Zoe Kemp,Maggie Gorman,Ian Chandler,Elli Papaemmanuil,Steven Penegar,Wendy Wood,Gabrielle S. Sellick,Mobshra Qureshi,Ana Teixeira,Enric Domingo,Ella Barclay,Lynn Martin,Lynn Martin,Oliver M. Sieber,David J. Kerr,Richard Gray,Julian Peto,Jean-Baptiste Cazier,Ian Tomlinson,Ian Tomlinson,Richard S. Houlston +33 more
TL;DR: Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (Ptrend = 1.0 × 10−12), and three SNPs in SMAD7 (involved in TGF-β and Wnt signaling) associated with CRC were identified.
Journal ArticleDOI
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
Wouter van Rheenen,Aleksey Shatunov,Annelot M. Dekker,Russell L. McLaughlin,Frank P. Diekstra,Sara L. Pulit,Rick A.A. van der Spek,Urmo Võsa,Simone de Jong,Simone de Jong,Matthew R. Robinson,Jian Yang,Isabella Fogh,Isabella Fogh,Perry T.C. van Doormaal,Gijs H.P. Tazelaar,Max Koppers,Anna M. Blokhuis,William Sproviero,Ashley R. Jones,Kevin P. Kenna,Kristel R. van Eijk,Oliver Harschnitz,Raymond D. Schellevis,William J. Brands,Jelena Medic,Androniki Menelaou,Alice Vajda,Alice Vajda,Nicola Ticozzi,Kuang Lin,Boris Rogelj,Katarina Vrabec,Metka Ravnik-Glavač,Blaž Koritnik,Janez Zidar,Lea Leonardis,Leja Dolenc Grošelj,Stéphanie Millecamps,François Salachas,Vincent Meininger,Mamede de Carvalho,Susana Pinto,Jesus S. Mora,Ricardo Rojas-García,Meraida Polak,Siddharthan Chandran,Shuna Colville,Robert Swingler,Karen E. Morrison,Pamela J. Shaw,John Hardy,Richard W. Orrell,Alan M. Pittman,Katie Sidle,Pietro Fratta,Andrea Malaspina,Simon Topp,Susanne Petri,Susanne Abdulla,Carsten Drepper,Michael Sendtner,Thomas F. Meyer,Roel A. Ophoff,Roel A. Ophoff,Roel A. Ophoff,Kim A. Staats,Martina Wiedau-Pazos,Catherine Lomen-Hoerth,Vivianna M. Van Deerlin,John Q. Trojanowski,Lauren Elman,Leo McCluskey,A. Nazli Basak,Ceren Tunca,Hamid Hamzeiy,Yesim Parman,Thomas Meitinger,Peter Lichtner,Milena Radivojkov-Blagojevic,Christian R. Andres,Cindy Maurel,Gilbert Bensimon,Bernhard Landwehrmeyer,Alexis Brice,Christine Payan,Safaa Saker-Delye,Alexandra Durr,Nicholas W. Wood,Lukas Tittmann,Wolfgang Lieb,Andre Franke,Marcella Rietschel,Sven Cichon,Markus M. Nöthen,Philippe Amouyel,Christophe Tzourio,Jean-François Dartigues,André G. Uitterlinden,Fernando Rivadeneira,Karol Estrada,Albert Hofman,Albert Hofman,Charles Curtis,Charles Curtis,Hylke M. Blauw,Anneke J. van der Kooi,Marianne de Visser,An Goris,Markus Weber,Christopher Shaw,Bradley N. Smith,Orietta Pansarasa,Cristina Cereda,Roberto Del Bo,Giacomo P. Comi,Sandra D'Alfonso,Cinzia Bertolin,Gianni Sorarù,Letizia Mazzini,Viviana Pensato,Cinzia Gellera,Cinzia Tiloca,Antonia Ratti,Andrea Calvo,Cristina Moglia,Maura Brunetti,Simona Arcuti,Rosa Capozzo,Chiara Zecca,Christian Lunetta,Silvana Penco,Nilo Riva,Alessandro Padovani,Massimiliano Filosto,Bernard Muller,Robbert Jan Stuit,Ian P. Blair,Katharine Y. Zhang,Emily P. McCann,Jennifer A. Fifita,Garth A. Nicholson,Garth A. Nicholson,Dominic B. Rowe,Roger Pamphlett,Matthew C. Kiernan,Julian Grosskreutz,Otto W. Witte,Thomas M. Ringer,Tino Prell,Beatrice Stubendorff,Ingo Kurth,Christian A. Hübner,P. Nigel Leigh,Federico Casale,Adriano Chiò,Ettore Beghi,Elisabetta Pupillo,Rosanna Tortelli,Giancarlo Logroscino,John Powell,Albert C. Ludolph,Jochen H. Weishaupt,Wim Robberecht,Philip Van Damme,Lude Franke,Tune H. Pers,Robert H. Brown,Jonathan D. Glass,John Landers,Orla Hardiman,Orla Hardiman,Peter M. Andersen,Peter M. Andersen,Philippe Corcia,Patrick Vourc'h,Vincenzo Silani,Naomi R. Wray,Peter M. Visscher,Paul I.W. de Bakker,Michael A. van Es,R. Jeroen Pasterkamp,Cathryn M. Lewis,Gerome Breen,Gerome Breen,Ammar Al-Chalabi,Leonard H. van den Berg,Jan H. Veldink +187 more
TL;DR: Evidence of ALS being a complex genetic trait with a polygenic architecture is established and the SNP-based heritability is estimated at 8.5%, with a distinct and important role for low-frequency variants (frequency 1–10%).