G
Gaby Palmer
Researcher at University of Geneva
Publications - 111
Citations - 7591
Gaby Palmer is an academic researcher from University of Geneva. The author has contributed to research in topics: Inflammation & Arthritis. The author has an hindex of 43, co-authored 99 publications receiving 6767 citations. Previous affiliations of Gaby Palmer include Geneva College.
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IL‐1, IL‐18, and IL‐33 families of cytokines
TL;DR: The interleukin‐1 (IL‐1), IL‐18, and IL‐33 families of cytokines are related by mechanism of origin, receptor structure, and signal transduction pathways utilized.
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IL-1 pathways in inflammation and human diseases
TL;DR: Preliminary results indicating that IL-1 targeting is efficacious in type 2 diabetes and smoldering myeloma have further broadened the spectrum of IL-2-driven diseases, and the role of microcrystals in the regulation ofIL-1β processing and release has provided the rationale for the use of IL
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The interleukin (IL)-1 cytokine family--Balance between agonists and antagonists in inflammatory diseases
TL;DR: Several genetic modifications or mutations associated with dysregulated IL-1 activity and autoinflammatory disorders were identified in mouse models and in patients and paved the road to the successful use of IL- 1 inhibitors in diseases that were previously considered as untreatable.
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Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation.
Jérôme Guicheux,J Lemonnier,J Lemonnier,Chafik Ghayor,Atsushi Suzuki,Atsushi Suzuki,Gaby Palmer,Joseph Caverzasio +7 more
TL;DR: It is reported that BMP‐2 can activate JNK and p38 in osteoblastic cells and evidence is provided that these MAP kinases have distinct roles in regulating alkaline phosphatase and osteocalcin expression.
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Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis.
Gaby Palmer,Dominique Talabot-Ayer,Céline Lamacchia,Dean Toy,Christian Alexander Seemayer,Sebastien Viatte,Axel Finckh,Dirk E. Smith,Cem Gabay +8 more
TL;DR: IL-33 is produced locally in inflamed joints, and neutralization of IL-33 signaling has a therapeutic effect on the course of arthritis, suggesting that locally produced IL- 33 may contribute to the pathogenesis of joint inflammation and destruction.