Journal ArticleDOI
The interleukin (IL)-1 cytokine family--Balance between agonists and antagonists in inflammatory diseases
TLDR
Several genetic modifications or mutations associated with dysregulated IL-1 activity and autoinflammatory disorders were identified in mouse models and in patients and paved the road to the successful use of IL- 1 inhibitors in diseases that were previously considered as untreatable.About:
This article is published in Cytokine.The article was published on 2015-11-01. It has received 348 citations till now. The article focuses on the topics: Decoy receptors & Interleukin 20.read more
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Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases
Mübeccel Akdis,Alar Aab,Can Altunbulakli,Kursat A Azkur,Rita Costa,Reto Crameri,Su Duan,Thomas Eiwegger,Andrzej Eljaszewicz,Ruth Ferstl,Remo Frei,Mattia Garbani,Anna Głobińska,Lena Hess,Carly Huitema,Terufumi Kubo,Zsolt István Komlósi,Patricia Konieczna,Nóra Kovács,Umut Can Kucuksezer,Norbert Meyer,Hideaki Morita,Judith Olzhausen,Liam O'Mahony,Marija Pezer,Moira Prati,Ana Rebane,Claudio Rhyner,Arturo Rinaldi,Milena Sokolowska,Barbara Stanic,Kazunari Sugita,Angela Treis,Willem van de Veen,Kerstin Wanke,Marcin Wawrzyniak,Paulina Wawrzyniak,Oliver F. Wirz,Josefina Zakzuk,Cezmi A. Akdis +39 more
TL;DR: Recent developments on IL-1 to IL-38, TNF-α, TGF-β, and interferons are reviewed and their cellular sources, targets, receptors, signaling pathways, and roles in immune regulation in patients with allergy and asthma and other inflammatory diseases are discussed.
Journal ArticleDOI
Pro-inflammatory cytokines: The link between obesity and osteoarthritis.
Tiantian Wang,Chengqi He +1 more
TL;DR: The relationship between obesity and inflammation, and the roles of IL-1, TNF-α and IL-6 in OA, is summarized and the possibility of using the pro-inflammatory signaling pathway as a therapeutic target to develop drugs for obesity-related OA is discussed.
Journal ArticleDOI
The Function of Fish Cytokines
Jun Zou,Christopher J. Secombes +1 more
TL;DR: Such studies begin to tell us about the role of these molecules in the regulation of fish immune responses and whether they are similar or divergent to the well-characterised functions of mammalian cytokines, to improve fish health in aquaculture.
Journal ArticleDOI
Interleukin 33 is a guardian of barriers and a local alarmin
TL;DR: A working model is developed that describes two 'lives' for IL-33—one intracellular and one extracellular, which coordinates immune defense and repair mechanisms while also initiating differentiation of helper T cells as the adaptive immune response is triggered.
Journal ArticleDOI
The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice
Rosalie Heilig,Rosalie Heilig,Mathias S. Dick,Lorenzo Sborgi,Etienne Meunier,Sebastian Hiller,Petr Broz,Petr Broz +7 more
TL;DR: It is shown using the murine system that gasdermin‐D is required for IL‐1β secretion by macrophages, dendritic cells and partially in neutrophils, and that secretion is a cell‐lysis‐independent event.
References
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Journal ArticleDOI
NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder
Laetitia Agostini,Fabio Martinon,Kimberly Burns,Michael F. McDermott,Philip N. Hawkins,Jürg Tschopp +5 more
TL;DR: It is reported that NALP2 and NalP3 associate with ASC, the CARD-containing protein Cardinal, and caspase-1 (but not casp enzyme-5), thereby forming an inflammasome with high proIL-1beta-processing activity.
Journal ArticleDOI
The Interleukin-1 Family: Back to the Future
TL;DR: The key properties of IL-1 family members are reviewed, with emphasis on pathways of negative regulation and orchestration of innate and adaptive immunity.
Journal ArticleDOI
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
TL;DR: Monotherapy blocking IL-1 activity in autoinflammatory syndromes results in a rapid and sustained reduction in disease severity, including reversal of inflammation-mediated loss of sight, hearing and organ function.
Journal ArticleDOI
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome
Hal M. Hoffman,James L. Mueller,David H. Broide,Alan A. Wanderer,Richard D. Kolodner,Richard D. Kolodner +5 more
TL;DR: A gene, called CIAS1, is expressed in peripheral blood leukocytes and encodes a protein with a pyrin domain, a nucleotide-binding site (NBS, NACHT subfamily) domain and a leucine-rich repeat (LRR) motif region, suggesting a role in the regulation of inflammation and apoptosis.
Journal ArticleDOI
Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4
Francesco Colotta,Fabio Re,Marta Muzio,Riccardo Bertini,Nadia Polentarutti,Marina Sironi,J G Giri,Steven K. Dower,John E. Sims,Alberto Mantovani +9 more
TL;DR: Results indicate thatIL-1 acts on myelomonocytic cells through IL-1R I and that IL- 1R II inhibits IL-2 activity by acting as a decoy target for IL-0, and the existence of multiple pathways of regulation emphasizes the need for tight control of IL-