Showing papers by "Gang Wang published in 2023"
TL;DR: In this paper , a flexible and degradable X-ray detector was fabricated with the highest sensitivity of 740.8 μC Gyair-1 cm-2 and low detection limit (0.14 nGyair s-1).
Abstract: Metal-free perovskites (MFPs) with flexible and degradable properties have been adopted in flexible X-ray detection. For now, figuring out the key factors between structure and device performance are critical to guide the design of MFPs. Herein, MPAZE-NH4I3•H2O was first designed and synthesized with improved structural stability and device performance. Through theoretical calculations, the introducing methyl group benefits modulating tolerance factor, increases dipole moment and strengthens hydrogen bonds. Meanwhile, H2O increases the hydrogen bond formation sites and synergistically realizes the band nature modulation, ionic migration inhibition and structural stiffness optimization. Spectra analysis also proves that the improved electron-phonon coupling and carrier recombination lifetime contribute to enhanced performance. Finally, a flexible and degradable X-ray detector was fabricated with the highest sensitivity of 740.8 μC Gyair-1 cm-2 and low detection limit (0.14 nGyair s-1).
6 citations
TL;DR: In this paper , the theory of regulating Th17/Treg cell equilibrium in RA is described from the perspectives of single Chinese medicine, active components of Chinese Medicine, Chinese medicine compounds, and other therapies of TCM.
Abstract: Rheumatoid arthritis (RA) is a persistent systemic autoimmune disease, having all the hallmarks of joint swelling, joint tenderness, and progressive joint destruction, with synovitis and pannus formation as the basic pathological changes. T‐lymphocyte infiltration is the key to its pathogenesis. During the growth of RA, the share of regulatory T (Treg) cells decreases, while the percentage of T helper type 17 (Th17) cells increases, giving rise to an imbalance of Th17/Treg cells. Modern medicine has made great advances in the treatment of RA and the selection of available drugs, but there are also the disadvantages of gastrointestinal reaction, high price, and low patient compliance. Therapy of RA remains a problem. Traditional Chinese medicine (TCM) has RA therapy developments, both in experimental research and clinical research, and its advantages of lasting effects and less detrimental reactions and fewer adverse effects are accepted by most patients. Numerous clinical and experimental studies have been performed in TCM on regulating Th17/Treg balance. However, the detailed mechanism of TCM intervention in Th17/Treg equilibrium in preventing and treating RA has not been discovered. In this article, the theory of regulating Th17/Treg cell equilibrium in RA is described from the perspectives of single Chinese medicine, active components of Chinese medicine, Chinese medicine compounds, and other therapies of TCM. It was found that TCM can regulate Th17/Treg cell balance and inhibit immunoreaction by intervening in cytokines, transcription factors, and signal pathways. It enables us to comprehensively and deeply understand the mechanism of TCM intervening in Th17/Treg balance in RA; provides direction for clinical therapy of RA; and offers new thoughts for understanding the pathogenesis of RA.
1 citations
1 citations
TL;DR: In this article , the specific function of chloroplast CA in intertidal macroalgae was explored using genomic technology, and the results provided valuable insights into the adaption mechanisms of inter-tidal microalgae to their environment.
Abstract: To adapt to the change of intertidal environment, intertidal macroalgae have evolved complicated Ci utilization mechanism. However, our knowledge regarding the CO2 concentrating mechanism (CCM) of macroalgae is limited. Carbonic anhydrase (CA), a key component of CCM, plays important roles in many physiological reactions in various organisms. While there are a large number of genes encoding CA in the Pyropia yezoensis genome, the exact function of specific CA in P. yezoensis remains elusive. To explore the specific function of chloroplast CA in intertidal macroalgae, we produced chloroplast-localized βCA1 knockdown mutants of P. yezoensis through RNA interference, and Pyca1i mutants showed a notable decrease in leaf area and overall biomass, as well as decreased soluble protein and unsaturated fatty acid content under different DIC conditions. However, Pyca1i mutants showed relatively higher starch content compared to the wild-type. The activity of enzymes involved in Calvin cycle, photorespiration, Pentose-phosphate pathway and floridean starch synthesis of P.yezoensis indicated an effective starch accumulation pathway after interference of βCA1. All results suggest that the decreased activity of PyβCA1 impaired the CCM and development of thalli of P.yezoensis, but stimulated starch accumulation in the cytoplasm through feedback to the photorespiration pathway and PP pathway to replenish intermediates for the Calvin cycle. This study is the first to explore the specific function of chloroplast CA in intertidal macroalgae using genomic technology. The results provide valuable insights into the adaption mechanisms of intertidal macroalgae to their environment.
TL;DR: In this paper , the authors summarize advances regarding how multi-component onco-condensates are established and organized to promote oncogenesis, with those related to chromatin and transcription deregulation used as showcases.
Abstract: Numerous cellular processes occur in the context of condensates, a type of large, membrane-less biomolecular assembly generated through phase separation. These condensates function as a hub of diversified cellular events by concentrating the required components. Cancer frequently coopts biomolecular condensation mechanisms to promote survival and/or proliferation. Onco-condensates, which refer to those that have causal roles or are critically involved in tumorigenicity, operate to abnormally elevate biological output of a proliferative process, or to suppress a tumor-suppressive pathway, thereby promoting oncogenesis. Here, we summarize advances regarding how multi-component onco-condensates are established and organized to promote oncogenesis, with those related to chromatin and transcription deregulation used as showcases. A better understanding should enable development of new means of targeting onco-condensates as potential therapeutics.
TL;DR: Wang et al. as discussed by the authors reviewed the progress of Hippo pathway and its main members in the pathogenesis of RA from three aspects: regulating the maintenance of autoimmune homeostasis, promoting the pathogenicity of synovial fibroblasts and regulating the differentiation of osteoclasts.
Abstract: Abstract Rheumatoid arthritis (RA) is a persistent systemic autoimmune disease with the hallmarks of swelling of the joint, joint tenderness, and progressive joint destruction, which may cause synovial inflammation and pannus as a basic pathological change, resulting in joint malformations and serious disorders. At present, the precise etiology and mechanism of pathogenesis of RA are unknown. The imbalance of immune homeostasis is the origin of RA. Hippo pathway is widely expressed in a range of cell lineages and plays a fundamental role in maintaining the immune steady state and may be involved in the pathogenic mechanism of RA. This study reviews the progress of Hippo pathway and its main members in the pathogenesis of RA from three aspects: regulating the maintenance of autoimmune homeostasis, promoting the pathogenicity of synovial fibroblasts and regulating the differentiation of osteoclasts. The study also presents a new way to recognize the pathogenesis of rheumatoid arthritis, which is favorable for finding a new way for treating the rheumatoid arthritis.
TL;DR: UNC8153 as mentioned in this paper is a NSD2-targeted degrader that can selectively reduce the cellular levels of both the SET domain-containing 2 (NSD2) and the H3K36me2 chromatin mark.
Abstract: Nuclear receptor-binding SET domain-containing 2 (NSD2) plays important roles in gene regulation, largely through its ability to dimethylate lysine 36 of histone 3 (H3K36me2). Despite aberrant activity of NSD2 reported in numerous cancers, efforts to selectively inhibit the catalytic activity of this protein with small molecules have been unsuccessful to date. Here, we report the development of UNC8153, a novel NSD2-targeted degrader that potently and selectively reduces the cellular levels of both NSD2 protein and the H3K36me2 chromatin mark. UNC8153 contains a simple warhead that confers proteasome-dependent degradation of NSD2 through a novel mechanism. Importantly, UNC8153-mediated reduction of H3K36me2 through the degradation of NSD2 results in the downregulation of pathological phenotypes in multiple myeloma cells including mild antiproliferative effects in MM1.S cells containing an activating point mutation and antiadhesive effects in KMS11 cells harboring the t(4;14) translocation that upregulates NSD2 expression.
TL;DR: In this paper , the authors proposed a novel x-ray detection system that achieves a temporal resolution of 930fs with photorefractive and four-wave mixing effects, which is the state-of-the-art.
Abstract: This study proposes what we believe to be a novel x-ray detection
system that achieves a temporal resolution of 930 fs with
photorefractive and four-wave mixing effects. The system comprises two
parts: a signal-conversion system and signal-acquisition system. The
signal-conversion system is based on the photorefractive effect, which
converts x-ray evolution into the variation of infrared interference
intensity. The signal-conversion sensor consists of ultra-fast
response LT-GaAs and a high-resolution interference cavity, achieving
a resolution of 767 fs. The signal-acquisition system
consists of a time-domain amplification system based on four-wave
mixing and a high-resolution signal-recording system with a resolution
of 21 ps, providing a temporal resolution of 525 fs.
TL;DR: In this article , the authors analyzed the refractive index change mechanism of the semiconductor under X-ray irradiation and established the quantitative relationship between the diffraction efficiency and the Xray photon energy through the LT-AlGaAs diffraction imaging experiments.
Abstract: Semiconductor sensors based on the rad-optic effect enable ultra-fast detection of X-rays and play an important role in fusion diagnostics. Obtaining the responsivity of the semiconductor ultrafast response material is an important part of characterization. In this work, the refractive index change mechanism of the semiconductor under X-ray irradiation was analyzed, and the quantitative relationship between the diffraction efficiency and the X-ray photon energy was established through the LT-AlGaAs diffraction imaging experiments. The impulse responses of LT-AlGaAs under 1 keV–10 keV X-ray radiation were calculated, revealing the variation of responsivity with radiated photon energy. Imaging experiments of LT-AlGaAs were performed by bombarding an Al target to generate 1.5 keV X-rays. The diffraction images were obtained in agreement with the simulations. The responsivity of the semiconductor chip increases with the square of the incident X-ray power density. This study provides meaningful analyses for the development of ultra-fast X-ray imaging systems based on the rad-optic effect.
TL;DR: In this article , the histone methyltransferase EZH2 has been studied most extensively in the context of PRC2-dependent gene repression, and it has been shown that EzH2-NF-κB positive regulation of genes and stemness does not require PRC 2.