G
Gang Wang
Researcher at Boston Children's Hospital
Publications - 9
Citations - 1892
Gang Wang is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Induced pluripotent stem cell & Regenerative medicine. The author has an hindex of 8, co-authored 9 publications receiving 1638 citations. Previous affiliations of Gang Wang include Medical Research Council & Harvard University.
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Journal ArticleDOI
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies
Gang Wang,Megan L. McCain,Luhan Yang,Aibin He,Francesco S. Pasqualini,Ashutosh Agarwal,Hongyan Yuan,Dawei Jiang,Donghui Zhang,Lior Zangi,Judith Geva,Amy E. Roberts,Qing Ma,Jian-Ping Ding,Jinghai Chen,Da-Zhi Wang,Kai Li,Jiwu Wang,Ronald J.A. Wanders,Wim Kulik,Frédéric M. Vaz,Michael A. Laflamme,Charles E. Murry,Kenneth R. Chien,Richard I. Kelley,George M. Church,Kevin Kit Parker,William T. Pu +27 more
TL;DR: This study combined patient-derived and genetically engineered induced pluripotent stem cells (iPSCs) with tissue engineering to elucidate the pathophysiology underlying the cardiomyopathy of Barth syndrome, a mitochondrial disorder caused by mutation of the gene encoding tafazzin (TAZ).
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Generation of Functional Human Hepatic Endoderm from Human Induced Pluripotent Stem Cells
Gareth J. Sullivan,David C. Hay,In-Hyun Park,Judy Fletcher,Zara Hannoun,Catherine Payne,Donna Dalgetty,James R. Black,James A. Ross,Kay Samuel,Gang Wang,George Q. Daley,Je-Hyuk Lee,George M. Church,Stuart J. Forbes,John P. Iredale,Ian Wilmut +16 more
TL;DR: This work is first to demonstrate the efficient generation of hepatic endodermal lineage from human iPSCs that exhibits key attributes of hepatocytes, and the potential application of iPSC‐derived HE in studying human liver biology.
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mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts.
Jinghai Chen,Zhan-Peng Huang,Hee Young Seok,Jian Ding,Masaharu Kataoka,Zheng Zhang,Xiaoyun Hu,Gang Wang,Zhiqiang Lin,Si Wang,Willam T. Pu,Ronglih Liao,Da-Zhi Wang +12 more
TL;DR: In this article, the miR-17-92 cluster was deleted from embryonic and postnatal mouse hearts and it was shown that miR 17-92 is required for cardiomyocyte proliferation in the heart.
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Optimization of Genome Engineering Approaches with the CRISPR/Cas9 System
TL;DR: Several parameters that influence Cas9-mediated scarless genome editing efficiency in murine embryonic stem cells are explored, providing guidance on optimal design of scarless gene knockout, modification, or knock-in experiments using Cas9 nuclease.
Journal ArticleDOI
Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells
Luhan Yang,Dennis Grishin,Gang Wang,John Aach,Cheng-Zhong Zhang,Raj Chari,Jason Homsy,Xuyu Cai,Yue Zhao,Jian-Bing Fan,Christine E. Seidman,Jonathan G. Seidman,William T. Pu,George M. Church +13 more
TL;DR: The study demonstrates the feasibility of highly specific clonal ex vivo gene editing using CRISPR/Cas9 and highlights the value of whole-genome sequencing before personalisedCRISPR design and identifies a single high-efficiency off-target site that is generated by a common germline single-nucleotide variant (SNV).