G
Garrett Hellenthal
Researcher at University College London
Publications - 76
Citations - 11454
Garrett Hellenthal is an academic researcher from University College London. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 34, co-authored 70 publications receiving 9592 citations. Previous affiliations of Garrett Hellenthal include University of Oxford & Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture
Nancy E. Bird,Louise Ormond,Paschal Kum Awah,Bruce Connell,Mohamed F. Elamin,Faisal M. Fadlelmola,Saioa López,Scott MacEachern,Yves Moñino,Sam Morris,Pieta Näsänen-Gilmore,Krishna R. Veeramah,Michael E. Weale,David Zeitlyn,Mark G. Thomas,Neil Bradman,Garrett Hellenthal +16 more
TL;DR: In this article , the authors analyzed new autosomal genetic variation data of 1333 individuals from over 150 ethnic groups from Cameroon, Republic of the Congo, Ghana, Nigeria, and Sudan, and demonstrated a previously underappreciated fine-scale level of genetic structure within these countries, for example, correlating with historical polities in western Cameroon.
Journal ArticleDOI
Structure and ancestry patterns of Ethiopians in genome-wide autosomal DNA.
TL;DR: A review of the current insights derived from the analyses of new large-scale, genome-wide autosomal variation data studies incorporating Ethiopians can be found in this article, where the authors demonstrate how genetic analyses can complement findings from anthropological and linguistic studies on Ethiopians.
Posted ContentDOI
The genetic legacy of Zoroastrianism in Iran and India: Insights into population structure, gene flow and selection.
Saioa López,Mark G. Thomas,Lucy van Dorp,Naser Ansari-Pour,Sarah Stewart,Abigail L. Jones,Erik Jelinek,Lounès Chikhi,Tudor Parfitt,Neil Bradman,Michael E. Weale,Garrett Hellenthal +11 more
TL;DR: It is shown that Zoroastrian in Iran and India show increased genetic homogeneity relative to other sampled groups in their respective countries, consistent with their current practices of endogamy, and genomic regions showing signatures of positive selection in present-day Zoroastrians that might correlate to the prevalence of particular diseases amongst these communities are reported.
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
Stephen Sawcer,Garrett Hellenthal,Matti Pirinen,Chris C. A. Spencer,Nikolaos A. Patsopoulos,Loukas Moutsianas,Alexander T. Dilthey,Zhan Su,Colin Freeman,Sarah E. Hunt,Sarah Edkins,Erin Gray,David R. Booth,Simon C. Potter,An Goris,A. Oturai,A. Strange,Janna Saarela,Céline Bellenguez,Bertrand Fontaine,Matthew W. Gillman,Bernhard Hemmer,R. Gwilliam,Frauke Zipp,Alagurevathi Jayakumar,Roland Martin,Stephen Leslie,Steve Hawkins,Eleni Giannoulatou,Sandra D'Alfonso,H. D. Blackburn,Filippo Martinelli Boneschi,Jennifer Liddle,Hanne F. Harbo,Maritza Pérez,Anne Spurkland,Matthew Waller,Marcin P. Mycko,Michelle Ricketts,Manuel Comabella,Naomi Hammond,Ingrid Kockum,O. T. McCann,Maria Ban,Pamela Whittaker,Anu Kemppinen,Paul A. Weston,Clive Hawkins,Sara Widaa,John Zajicek,Serge Dronov,Neil Robertson,Suzannah Bumpstead,Lisa F. Barcellos,Radhi Ravindrarajah,Roby Abraham,Lars Alfredsson,Kristin G. Ardlie,Cristin Aubin,Amie Baker,Kristi Baker,Sergio E. Baranzini,Laura Bergamaschi,Roberto Bergamaschi,Audrey M. Bernstein,Achim Berthele,Mike Boggild,Jonathan P. Bradfield,David Brassat,Simon Broadley,Dorothea Buck,Helmut Butzkueven,Ruggero Capra,William M. Carroll,Paola Cavalla,Elisabeth Gulowsen Celius,Sabine Cepok,Rosetta M. Chiavacci,Françoise Clerget-Darpoux,Katleen Clysters,Giancarlo Comi,Mark D. Cossburn,Isabelle Cournu-Rebeix,M. B. Cox,Wendy Cozen,Bruce A.C. Cree,Anne H. Cross,Daniele Cusi,Mark J. Daly,Emma J. Davis,P. I. W. de Bakker,Marc Debouverie,Marie B. D'hooghe,K Dixon,Rita Dobosi,Bénédicte Dubois,David Ellinghaus,Irina Elovaara,Federica Esposito,Claire Fontenille,Simon J. Foote,Andre Franke,Daniela Galimberti,Angelo Ghezzi,Joseph T. Glessner,Refujia Gomez,Olivier Gout,Colin M. Graham,Struan F.A. Grant,Franca Rosa Guerini,Hakon Hakonarson,Per Hall,Anders Hamsten,H.-P. Hartung,Robert Heard,Simon Heath,Jeremy Hobart,M.-M. Hoshi,Carmen Infante-Duarte,Gillian Ingram,Wendy Ingram,Talat Islam,Maja Jagodic,Michael Kabesch,Allan G. Kermode,Trevor J. Kilpatrick,Cecilia Kim,N Klopp,Keijo Koivisto,Malin Larsson,M Lathrop,Jeannette Lechner-Scott,Maurizio Leone,Virpi M. Leppä,Ulrika Liljedahl,Izaura Lima Bomfim,Robin R. Lincoln,J. Link,Jianjun Liu,Åslaug R. Lorentzen,Sara Lupoli,Fabio Macciardi,Thomas M. Mack,Mark Marriott,Vittorio Martinelli,Deborah F. Mason,Jacob L. McCauley,Frank D. Mentch,Inger-Lise Mero,Tania Mihalova,Xavier Montalban,John Mottershead,Kjell-Morten Myhr,Paola Naldi,William E R Ollier,A. Page,Aarno Palotie,Jean Pelletier,Laura Piccio,Trevor Pickersgill,Fredrik Piehl,Susan Pobywajlo,H. L. Quach,Patricia P. Ramsay,Mauri Reunanen,Richard Reynolds,John D. Rioux,Mariaemma Rodegher,S. Roesner,Justin P. Rubio,Ina Maria Rückert,Marco Salvetti,Erika Salvi,Adam Santaniello,Cathy Schaefer,Stefan Schreiber,Christian Schulze,Rodney J. Scott,Finn Sellebjerg,Krzysztof Selmaj,David Sexton,Ling Shen,B. Simms-Acuna,S. Skidmore,Patrick M. A. Sleiman,C. Smestad,Per Soelberg Sørensen,Helle Bach Søndergaard,Jim Stankovich,Richard C. Strange,Anna-Maija Sulonen,E. Sundqvist,Ann-Christine Syvänen,F. Taddeo,Bruce V. Taylor,Jenefer M. Blackwell,Pentti J. Tienari,Elvira Bramon,Ayman Tourbah,Matthew A. Brown,Ewa Tronczynska,Juan P. Casas,Niall Tubridy,Aiden Corvin,Jane Vickery,Janusz Jankowski,Pablo Villoslada,Hugh S. Markus,Kai Wang,Christopher G. Mathew,James Wason,Colin N. A. Palmer,Erich Wichmann,Robert Plomin,Ernie Willoughby,Anna Rautanen,Juliane Winkelmann,Michael Wittig,Richard C. Trembath,J. Yaouanq,Ananth C. Viswanathan,Haitao Zhang,Nicholas W. Wood,Rebecca L. Zuvich,Panos Deloukas,Cordelia Langford,Audrey Duncanson,Jorge R. Oksenberg,Margaret A. Pericak-Vance,Jonathan L. Haines,Tomas Olsson,Jan Hillert,A Ivinson,P. L. De Jager,Leena Peltonen,Graeme J. Stewart,David A. Hafler,Stephen L. Hauser,Gil McVean,Peter Donnelly,Alastair Compston +240 more
TL;DR: Moderate powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility.
The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis
Philip Robinson,Paul Leo,J J Pointon,Jade Harris,Katie Cremin,Linda A. Bradbury,Peter Donnelly,Inês Barroso,Jenefer M. Blackwell,Elvira Bramon,Brown,Juan P. Casas,Aiden Corvin,Panagiotis Deloukas,Audrey Duncanson,Janusz Jankowski,Hugh S. Markus,Christopher G. Mathew,Colin N. A. Palmer,Robert Plomin,Anna Rautanen,Stephen Sawcer,Richard C. Trembath,Ananth C. Viswanathan,Nicholas W. Wood,C. C. A. Spencer,Céline Bellenguez,Colin Freeman,Garrett Hellenthal,Eleni Giannoulatou,Matti Pirinen,Rebecca M. Pearson,A. Strange,Zhan Su,Damjan Vukcevic,Cordelia Langford,Sarah E. Hunt,Sarah Edkins,R. Gwilliam,H. D. Blackburn,Suzannah Bumpstead,Serge Dronov,Matthew Gillman,Erin Gray,Naomi Hammond,Alagurevathi Jayakumar,O. T. McCann,Jennifer Liddle,Simon C. Potter,Radhi Ravindrarajah,Michelle Ricketts,Matthew Waller,Paul A. Weston,Sara Widaa,Pamela Whittaker,Eugene V. McCloskey,John A. Eisman,Graeme Jones,G.C. Nicholson,R. Eastell,P. N. Sambrook,Richard L. Prince,Elaine M. Dennison,Ian R. Reid,John D. Wark,Simon Stebbings,Andrew A. Harrison,David M. Evans,Emma L. Duncan,B P Wordsworth +69 more
TL;DR: In this paper, the authors used the Illumina Exomechip microarray to compare 1504 cases with AS and AAU, 1805 with AS but no AAU and 21 133 healthy controls.