S
Sara Lupoli
Researcher at University of Milan
Publications - 37
Citations - 4634
Sara Lupoli is an academic researcher from University of Milan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 19, co-authored 35 publications receiving 4203 citations. Previous affiliations of Sara Lupoli include Vita-Salute San Raffaele University.
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Journal ArticleDOI
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
Stephen Sawcer,Garrett Hellenthal,Matti Pirinen,Chris C. A. Spencer,Nikolaos A. Patsopoulos,Nikolaos A. Patsopoulos,Nikolaos A. Patsopoulos,Loukas Moutsianas,Alexander T. Dilthey,Zhan Su,Colin Freeman,Sarah E. Hunt,Sarah Edkins,Emma Gray,David R. Booth,Simon C. Potter,An Goris,Gavin Band,Annette Bang Oturai,A. Strange,Janna Saarela,Céline Bellenguez,Bertrand Fontaine,Matthew W. Gillman,Bernhard Hemmer,Rhian Gwilliam,Frauke Zipp,Alagurevathi Jayakumar,Roland Martin,Stephen Leslie,Stanley Hawkins,Eleni Giannoulatou,Sandra D'Alfonso,Hannah Blackburn,Filippo Martinelli Boneschi,Jennifer Liddle,Hanne F. Harbo,Hanne F. Harbo,M. Perez,Anne Spurkland,Matthew Waller,Marcin P. Mycko,Michelle Ricketts,Manuel Comabella,Naomi Hammond,Ingrid Kockum,O. T. McCann,Maria Ban,Pamela Whittaker,Anu Kemppinen,Paul A. Weston,Clive Hawkins,Sara Widaa,John Zajicek,John Zajicek,Serge Dronov,Neil Robertson,Suzannah Bumpstead,Lisa F. Barcellos,Lisa F. Barcellos,Rathi Ravindrarajah,Roby Abraham,Lars Alfredsson,Kristin G. Ardlie,Cristin Aubin,Amie Baker,K Baker,Sergio E. Baranzini,Laura Bergamaschi,Roberto Bergamaschi,Allan L. Bernstein,Achim Berthele,Mike Boggild,Jonathan P. Bradfield,David Brassat,Simon Broadley,Dorothea Buck,Helmut Butzkueven,Ruggero Capra,William M. Carroll,Paola Cavalla,Elisabeth Gulowsen Celius,Sabine Cepok,Rosetta M. Chiavacci,Françoise Clerget-Darpoux,Katleen Clysters,Giancarlo Comi,Mark D. Cossburn,Isabelle Cournu-Rebeix,M. B. Cox,Wendy Cozen,Bruce A.C. Cree,Anne H. Cross,Daniele Cusi,Mark J. Daly,Mark J. Daly,Emma J. Davis,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Marc Debouverie,Marie B. D'hooghe,K Dixon,Rita Dobosi,Bénédicte Dubois,David Ellinghaus,Irina Elovaara,Federica Esposito,Claire Fontenille,Simon J. Foote,Andre Franke,Daniela Galimberti,Angelo Ghezzi,Joseph T. Glessner,Refujia Gomez,Olivier Gout,Colin A. Graham,Struan F.A. Grant,Struan F.A. Grant,Franca Rosa Guerini,Hakon Hakonarson,Hakon Hakonarson,Per Hall,Anders Hamsten,Hans-Peter Hartung,Robert Heard,Simon Heath,Jeremy Hobart,Jeremy Hobart,Muna Hoshi,Carmen Infante-Duarte,Gillian Ingram,Wendy Ingram,Wendy Ingram,Talat Islam,Maja Jagodic,Michael Kabesch,Allan G. Kermode,Trevor J. Kilpatrick,Cecilia Kim,Norman Klopp,Keijo Koivisto,Malin Larsson,Mark Lathrop,Jeannette Lechner-Scott,Maurizio Leone,Virpi M. Leppä,Ulrika Liljedahl,Izaura Lima Bomfim,Robin R. Lincoln,Jenny Link,Jianjun Liu,Åslaug R. Lorentzen,Åslaug R. Lorentzen,Sara Lupoli,Fabio Macciardi,Fabio Macciardi,Thomas M. Mack,Mark Marriott,Vittorio Martinelli,Deborah F. Mason,Jacob L. McCauley,Frank D. Mentch,Inger-Lise Mero,Tania Mihalova,Xavier Montalban,John Mottershead,Kjell-Morten Myhr,Paola Naldi,William E R Ollier,Alison Page,Aarno Palotie,Jean Pelletier,Laura Piccio,Trevor Pickersgill,Fredrik Piehl,Susan Pobywajlo,Hong L. Quach,Patricia P. Ramsay,Mauri Reunanen,Richard Reynolds,John D. Rioux,John D. Rioux,Mariaemma Rodegher,Sabine Roesner,Justin P. Rubio,Ina-Maria Rueckert,Marco Salvetti,Erika Salvi,Adam Santaniello,Catherine Schaefer,Stefan Schreiber,Christian Schulze,Rodney J. Scott,Finn Sellebjerg,Krzysztof Selmaj,David Sexton,Ling Shen,Brigid Simms-Acuna,Sheila Skidmore,Patrick M. A. Sleiman,C. Smestad,Per Soelberg Sørensen,Helle Bach Søndergaard,Jim Stankovich,Richard C. Strange,Anna-Maija Sulonen,Emilie Sundqvist,Ann-Christine Syvaenen,Francesca Taddeo,Bruce V. Taylor,Jenefer M. Blackwell,Jenefer M. Blackwell,Jenefer M. Blackwell,Pentti J. Tienari,Elvira Bramon,Ayman Tourbah,Matthew A. Brown,Ewa Tronczynska,Juan P. Casas,Niall Tubridy,Aiden Corvin,Jane Vickery,Jane Vickery,Janusz Jankowski,Pablo Villoslada,Hugh S. Markus,Kai Wang,Christopher G. Mathew,James Wason,Colin N. A. Palmer,H-Erich Wichmann,H-Erich Wichmann,Robert Plomin,Ernest Willoughby,Anna Rautanen,Juliane Winkelmann,Michael Wittig,Richard C. Trembath,J. Yaouanq,Ananth C. Viswanathan,Ananth C. Viswanathan,Haitao Zhang,Nicholas W. Wood,Rebecca L. Zuvich,Panos Deloukas,Cordelia Langford,Audrey Duncanson,Jorge R. Oksenberg,Margaret A. Pericak-Vance,Jonathan L. Haines,Tomas Olsson,Jan Hillert,Adrian J. Ivinson,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Leena Peltonen,Graeme J. Stewart,David A. Hafler,David A. Hafler,Stephen L. Hauser,Gil McVean,Peter Donnelly,Peter Donnelly,Alastair Compston +265 more
TL;DR: In this article, a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, they have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci.
Journal ArticleDOI
Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.
Steven G. Potkin,Guia Guffanti,Guia Guffanti,Anita Lakatos,Jessica A. Turner,Frithjof Kruggel,James H. Fallon,Andrew J. Saykin,Alessandro Orro,Sara Lupoli,Erika Salvi,Michael P. Weiner,Fabio Macciardi,Fabio Macciardi +13 more
TL;DR: Using hippocampal atrophy as a quantitative phenotype in a genome-wide scan, candidate risk genes for sporadic Alzheimer's disease that merit further investigation are identified.
Journal ArticleDOI
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
Xiangdong Liu,Pietro Invernizzi,Yue Lu,Roman Kosoy,Yan Lu,Ilaria Bianchi,Mauro Podda,Chun Xu,Gang Xie,Fabio Macciardi,Fabio Macciardi,Carlo Selmi,Carlo Selmi,Sara Lupoli,Russell Shigeta,Michael Ransom,Ana Lleo,Ana Lleo,Annette Lee,Andrew Mason,Robert P. Myers,Kevork M. Peltekian,Cameron N. Ghent,Francesca Bernuzzi,Massimo Zuin,Floriano Rosina,Elisabetta Borghesio,Annarosa Floreani,Roberta Lazzari,Grazia Anna Niro,Angelo Andriulli,Luigi Muratori,Paolo Muratori,Piero Luigi Almasio,Pietro Andreone,Marzia Margotti,Maurizia Rossana Brunetto,Barbara Coco,Domenico Alvaro,Maria Consiglia Bragazzi,Fabio Marra,Alessandro Pisano,Cristina Rigamonti,Massimo Colombo,Marco Marzioni,Antonio Benedetti,Luca Fabris,Mario Strazzabosco,Mario Strazzabosco,Piero Portincasa,Vincenzo Palmieri,Claudio Tiribelli,Lory Saveria Crocè,S. Bruno,Sonia Rossi,Maria Vinci,Cleofe Prisco,Alberto Mattalia,Pierluigi Toniutto,Antonio Picciotto,Andrea Galli,Carlo Ferrari,Silvia Colombo,Giovanni Casella,Lorenzo Morini,Nicola Caporaso,Agostino Colli,Giancarlo Spinzi,Renzo Montanari,Peter K. Gregersen,E. Jenny Heathcote,Gideon M. Hirschfield,Katherine A. Siminovitch,Christopher I. Amos,M. Eric Gershwin,Michael F. Seldin +75 more
TL;DR: A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB.
Journal ArticleDOI
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Anne E. Justice,Thomas W. Winkler,Mary F. Feitosa,Misa Graff,Virginia Fisher,Kristin L. Young,Llilda Barata,Xuan Deng,Jacek Czajkowski,David Hadley,Julius S. Ngwa,Julius S. Ngwa,Tarunveer S. Ahluwalia,Tarunveer S. Ahluwalia,Audrey Y. Chu,Audrey Y. Chu,Nancy L. Heard-Costa,Nancy L. Heard-Costa,Elise Lim,Jeremiah Perez,John D. Eicher,Zoltán Kutalik,Luting Xue,Anubha Mahajan,Frida Renström,Frida Renström,Joseph M. Wu,Qibin Qi,Shafqat Ahmad,Shafqat Ahmad,Tamuno Alfred,Najaf Amin,Lawrence F. Bielak,Amélie Bonnefond,Jennifer Bragg,Gemma Cadby,Martina Chittani,Scott Coggeshall,Tanguy Corre,Nese Direk,Nese Direk,Joel Eriksson,Krista Fischer,Mathias Gorski,Marie Neergaard Harder,Momoko Horikoshi,Tao Huang,Tao Huang,Jennifer E. Huffman,Jennifer E. Huffman,Anne U. Jackson,Johanne Marie Justesen,Stavroula Kanoni,Leena Kinnunen,Marcus E. Kleber,Pirjo Komulainen,Meena Kumari,Meena Kumari,Unhee Lim,Jian'an Luan,Leo-Pekka Lyytikäinen,Massimo Mangino,Massimo Mangino,Ani Manichaikul,Jonathan Marten,Rita P. S. Middelberg,Martina Müller-Nurasyid,Pau Navarro,Louis Pérusse,Natalia Pervjakova,Cinzia Sarti,Albert V. Smith,Jennifer A. Smith,Alena Stančáková,Rona J. Strawbridge,Heather M. Stringham,Yun Ju Sung,Toshiko Tanaka,Alexander Teumer,Stella Trompet,Sander W. van der Laan,Peter J. van der Most,Jana V. van Vliet-Ostaptchouk,Sailaja Vedantam,Sailaja Vedantam,Niek Verweij,Jacqueline M. Vink,Jacqueline M. Vink,Veronique Vitart,Ying Wu,Loic Yengo,Weihua Zhang,Weihua Zhang,Jing Hua Zhao,Martina E. Zimmermann,Niha Zubair,Gonçalo R. Abecasis,Linda S. Adair,Saima Afaq,Saima Afaq,Uzma Afzal,Uzma Afzal,Stephan J. L. Bakker,Traci M. Bartz,John Beilby,John Beilby,Richard N. Bergman,Sven Bergmann,Reiner Biffar,John Blangero,Eric Boerwinkle,Lori L. Bonnycastle,Erwin P. Bottinger,Daniele Braga,Brendan M. Buckley,Steve Buyske,Harry Campbell,John C. Chambers,John C. Chambers,Francis S. Collins,Joanne E. Curran,Gert J. de Borst,Anton J. M. de Craen,Eco J. C. de Geus,George Dedoussis,Graciela E. Delgado,Hester M. den Ruijter,Gudny Eiriksdottir,Anna Eriksson,Tõnu Esko,Tõnu Esko,Tõnu Esko,Jessica D. Faul,Ian Ford,Terrence Forrester,Karl Gertow,Bruna Gigante,Nicola Glorioso,Jian Gong,Harald Grallert,Tanja B. Grammer,Niels Grarup,Saskia Haitjema,Göran Hallmans,Anders Hamsten,Torben Hansen,Tamara B. Harris,Catharina A. Hartman,Maija Hassinen,Nicholas D. Hastie,Andrew C. Heath,Dena G. Hernandez,Lucia A. Hindorff,Lynne J. Hocking,Lynne J. Hocking,Mette Hollensted,Oddgeir L. Holmen,Georg Homuth,Jouke-Jan Hottenga,Jie Huang,Joseph Hung,Joseph Hung,Nina Hutri-Kähönen,Erik Ingelsson,Erik Ingelsson,Alan James,Alan James,John-Olov Jansson,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Min A. Jhun,Marit E. Jørgensen,Markus Juonala,Mika Kähönen,Magnus Karlsson,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Ivana Kolcic,Genovefa Kolovou,Charles Kooperberg,Bernhard K. Krämer,Johanna Kuusisto,Kirsti Kvaløy,Timo A. Lakka,Claudia Langenberg,Lenore J. Launer,Karin Leander,Nanette R. Lee,Lars Lind,Cecilia M. Lindgren,Allan Linneberg,Stéphane Lobbens,Marie Loh,Marie Loh,Mattias Lorentzon,Robert Luben,Gitta H. Lubke,Anja Ludolph-Donislawski,Sara Lupoli,Pamela A. F. Madden,Reija Männikkö,Pedro Marques-Vidal,Nicholas G. Martin,Colin A. McKenzie,Barbara McKnight,Barbara McKnight,Dan Mellström,Cristina Menni,Grant W. Montgomery,Arthur W. Musk,Arthur W. Musk,Narisu Narisu,Matthias Nauck,Ilja M. Nolte,Albertine J. Oldehinkel,Matthias Olden,Ken K. Ong,Sandosh Padmanabhan,Sandosh Padmanabhan,Patricia A. Peyser,Charlotta Pisinger,David J. Porteous,Olli T. Raitakari,Tuomo Rankinen,Dabeeru C. Rao,Laura J. Rasmussen-Torvik,Rajesh Rawal,Treva Rice,Paul M. Ridker,Lynda M. Rose,Stephanie A. Bien,Igor Rudan,Serena Sanna,Mark A. Sarzynski,Naveed Sattar,Kai Savonen,David Schlessinger,Salome Scholtens,Claudia Schurmann,Robert A. Scott,Bengt Sennblad,Marten A. Siemelink,Günther Silbernagel,P. Eline Slagboom,Harold Snieder,Jan A. Staessen,Jan A. Staessen,David J. Stott,Morris A. Swertz,Amy J. Swift,Kent D. Taylor,Bamidele O. Tayo,Barbara Thorand,Dorothée Thuillier,Jaakko Tuomilehto,André G. Uitterlinden,Liesbeth Vandenput,Marie-Claude Vohl,Henry Völzke,Judith M. Vonk,Gérard Waeber,Melanie Waldenberger,Rudi G. J. Westendorp,Sarah H. Wild,Gonneke Willemsen,Bruce H. R. Wolffenbuttel,Andrew Wong,Alan F. Wright,Wei Zhao,M. Carola Zillikens,Damiano Baldassarre,Beverley Balkau,Stefania Bandinelli,Carsten A. Böger,Dorret I. Boomsma,Claude Bouchard,Marcel Bruinenberg,Daniel I. Chasman,Yii-Der Ida Chen,Peter S. Chines,Richard S. Cooper,Francesco Cucca,Daniele Cusi,Ulf de Faire,Luigi Ferrucci,Paul W. Franks,Paul W. Franks,Paul W. Franks,Philippe Froguel,Penny Gordon-Larsen,Hans J. Grabe,Hans J. Grabe,Vilmundur Gudnason,Christopher A. Haiman,Caroline Hayward,Kristian Hveem,Andrew D. Johnson,J. Wouter Jukema,Sharon L.R. Kardia,Mika Kivimäki,Jaspal S. Kooner,Jaspal S. Kooner,Diana Kuh,Markku Laakso,Terho Lehtimäki,Loic Le Marchand,Winfried März,Winfried März,Mark I. McCarthy,Mark I. McCarthy,Andres Metspalu,Andrew P. Morris,Andrew P. Morris,Claes Ohlsson,Lyle J. Palmer,Gerard Pasterkamp,Oluf Pedersen,Annette Peters,Ulrike Peters,Ozren Polasek,Ozren Polasek,Bruce M. Psaty,Bruce M. Psaty,Lu Qi,Lu Qi,Rainer Rauramaa,Blair H. Smith,Blair H. Smith,Thorkild I. A. Sørensen,Thorkild I. A. Sørensen,Konstantin Strauch,Henning Tiemeier,Elena Tremoli,Pim van der Harst,Henrik Vestergaard,Henrik Vestergaard,Peter Vollenweider,Nicholas J. Wareham,David R. Weir,John Whitfield,James F. Wilson,Jessica Tyrrell,Timothy M. Frayling,Inês Barroso,Inês Barroso,Michael Boehnke,Panagiotis Deloukas,Panagiotis Deloukas,Panagiotis Deloukas,Caroline S. Fox,Joel N. Hirschhorn,Joel N. Hirschhorn,David J. Hunter,David J. Hunter,Tim D. Spector,David P. Strachan,Cornelia M. van Duijn,Iris M. Heid,Karen L. Mohlke,Jonathan Marchini,Ruth J. F. Loos,Ruth J. F. Loos,Tuomas O. Kilpeläinen,Tuomas O. Kilpeläinen,Tuomas O. Kilpeläinen,Ching-Ti Liu,Ingrid B. Borecki,Kari E. North,L. Adrienne Cupples,L. Adrienne Cupples +370 more
TL;DR: The results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution, and highlight the importance of accounting for environment in genetic analyses.
Journal ArticleDOI
Genomewide Association Study Using a High-Density Single Nucleotide Polymorphism Array and Case-Control Design Identifies a Novel Essential Hypertension Susceptibility Locus in the Promoter Region of Endothelial NO Synthase
Erika Salvi,Zoltán Kutalik,Nicola Glorioso,Paola Benaglio,Francesca Frau,Tatiana Kuznetsova,Hisatomi Arima,Clive J. Hoggart,Jean Tichet,Y Nikitin,Costanza Conti,Jitka Seidlerová,Valérie Tikhonoff,Katarzyna Stolarz-Skrzypek,Toby Johnson,Nabila Devos,Laura Zagato,Simonetta Guarrera,Roberta Zaninello,Andrea Calabria,Benedetta Stancanelli,Chiara Troffa,Lutgarde Thijs,Federica Rizzi,Galina Simonova,Sara Lupoli,Giuseppe Argiolas,Daniele Braga,Maria C. D'Alessio,Maria Francesca Ortu,Fulvio Ricceri,Maurizio Mercurio,Patrick Descombes,Maurizio Marconi,John Chalmers,Stephen B. Harrap,Jan Filipovsky,Murielle Bochud,Licia Iacoviello,Justine A. Ellis,Alice Stanton,Maris Laan,Sandosh Padmanabhan,Anna F. Dominiczak,Nilesh J. Samani,Olle Melander,Xavier Jeunemaitre,Paolo Manunta,Amnon Shabo,Paolo Vineis,Francesco P. Cappuccio,Mark J. Caulfield,Giuseppe Matullo,Carlo Rivolta,Patricia B. Munroe,Cristina Barlassina,Jan A. Staessen,Jacques S. Beckmann,Daniele Cusi +58 more
TL;DR: Biological evidence links endothelial NO synthase with hypertension, because it is a critical mediator of cardiovascular homeostasis and blood pressure control via vascular tone regulation, and the hypothesis that there may be a causal genetic variation at this locus is supported.