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Yukio Tanizawa
Researcher at Yamaguchi University
Publications - 148
Citations - 5453
Yukio Tanizawa is an academic researcher from Yamaguchi University. The author has contributed to research in topics: Unfolded protein response & Wolfram syndrome. The author has an hindex of 37, co-authored 139 publications receiving 4734 citations.
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A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)
Hiroshi Inoue,Yukio Tanizawa,Jon Wasson,Philip Behn,Kamini Kalidas,Ernesto Bernal-Mizrachi,Mike Mueckler,Helen Marshall,Helen Donis-Keller,Patricia Crock,Douglas Rogers,Masahiko Mikuni,Hisashi Kumashiro,Koichiro Higashi,Gen Sobue,Yoshitomo Oka,M. Alan Permutt +16 more
TL;DR: In this paper, the authors localized the Wolfram syndrome (WFS) gene to a BAC/P1 contig of less than 250 kb and found that mutations in a novel gene encoding a putative transmembrane protein were associated with the disease phenotype.
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WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain
Koumei Takeda,Hiroshi Inoue,Yukio Tanizawa,Yumiko Matsuzaki,Jun Oba,Yoshifumi Watanabe,Koh Shinoda,Yoshitomo Oka +7 more
TL;DR: A specific antibody against the C-terminus of the WFS1 protein is generated and its subcellular localization in cultured cells suggests that this protein plays an as yet undefined role in membrane trafficking, protein processing and/or regulation of ER calcium homeostasis.
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Disruption of the WFS1 gene in mice causes progressive β-cell loss and impaired stimulus–secretion coupling in insulin secretion
Hisamitsu Ishihara,Satoshi Takeda,Akira Tamura,Rui Takahashi,Suguru Yamaguchi,Daisuke Takei,Takahiro Yamada,Hiroshi Inoue,Hiroyuki Soga,Hideki Katagiri,Yukio Tanizawa,Yoshitomo Oka +11 more
TL;DR: It is suggested that WFS1 protein plays an important role in both stimulus-secretion coupling for insulin exocytosis and maintenance of beta-cell mass, deterioration of which leads to impaired glucose homeostasis.
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Japanese Clinical Practice Guideline for Diabetes 2019
Eiichi Araki,Atsushi Goto,Tatsuya Kondo,Mitsuhiko Noda,Hiroshi Noto,Hideki Origasa,Haruhiko Osawa,Akihiko Taguchi,Yukio Tanizawa,Kazuyuki Tobe,Narihito Yoshioka +10 more
TL;DR: The current guideline represents the 6th edition of the “Japanese Clinical Practice Guideline for Diabetes” and it is hoped that the guideline will prove a helpful guide to evidence-based medicine (EBM) in clinical settings thereby.
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Molecular mimicry by Helicobacter pylori CagA protein may be involved in the pathogenesis of H. pylori‐associated chronic idiopathic thrombocytopenic purpura
Toru Takahashi,Toshiaki Yujiri,Kenji Shinohara,Yusuke Inoue,Yutaka Sato,Fujii Y,Masashi Okubo,Yuzuru Zaitsu,Koichi Ariyoshi,Yukinori Nakamura,Ryouhei Nawata,Yoshitomo Oka,Mutsunori Shirai,Yukio Tanizawa +13 more
TL;DR: Cross‐reactivity between PAIgG and H. pylori CagA protein suggests that molecular mimicry by Cag a plays a key role in the pathogenesis of a subset of cITP patients.