G
Genlin Hu
Researcher at University of North Carolina at Chapel Hill
Publications - 5
Citations - 386
Genlin Hu is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Adeno-associated virus & Clotting factor. The author has an hindex of 5, co-authored 5 publications receiving 322 citations.
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Journal ArticleDOI
Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia.
Chengwen Li,Nattee Narkbunnam,Nattee Narkbunnam,Richard Jude Samulski,Aravind Asokan,Genlin Hu,L. J. Jacobson,M. J. Manco-Johnson,Paul E. Monahan,Marilyn J. Manco-Johnson,Brenda Riske,Ray F. Kilcoyne,M L Manco-Johnson,Sharon Funk,Linda J. Jacobson,J. David Ingram,Thomas C. Abshire,Thomas C. Abshire,Amy D. Shapiro,Michele R. Hacker,Leonard A. Valentino,W. Keith Hoots,Deborah L Brown,George R. Buchanan,Donna DiMichele,Michael Recht,Cindy A. Leissinger,Shirley Bleak,Alan R. Cohen,Prasad Mathew,Alison Matsunaga,Desiree Medeiros,Diane J. Nugent,Gregory Thomas,Alexis A. Thompson,Kevin McRedmond,J. Michael Soucie,Harlan Austin,Bruce L. Evatt +38 more
TL;DR: The results may guide rational design of clinical trials using alternative AAV serotypes and suggest that younger patients who are given AAV gene therapy will benefit from the lower prevalence of NAbs.
Journal ArticleDOI
Employing a Gain-of-Function Factor IX Variant R338L to Advance the Efficacy and Safety of Hemophilia B Human Gene Therapy: Preclinical Evaluation Supporting an Ongoing Adeno-Associated Virus Clinical Trial
Paul E. Monahan,Junjiang Sun,Tong Gui,Genlin Hu,William B. Hannah,David Wichlan,Zhijian Wu,Zhijian Wu,Joshua C Grieger,Chengwen Li,Thipparat Suwanmanee,Darrel W. Stafford,Carmen J. Booth,Jade Samulski,Tal Kafri,Scott W.J. McPhee,Richard Jude Samulski +16 more
TL;DR: Preclinical studies demonstrate a safety:efficacy profile supporting an ongoing phase 1/2 human clinical trial of the scAAV8.FIXR338L vector and the role of empty capsids, as well as performing comprehensive dose–response, biodistribution, and safety evaluations in clinically relevant hemophilia models.
Journal ArticleDOI
Integration-deficient Lentiviral Vectors Expressing Codon-optimized R338L Human FIX Restore Normal Hemostasis in Hemophilia B Mice
Thipparat Suwanmanee,Genlin Hu,Tong Gui,Cynthia C. Bartholomae,Ina Kutschera,Christof von Kalle,Manfred Schmidt,Paul E. Monahan,Tal Kafri +8 more
TL;DR: This study demonstrates that IDLVs carrying an improved human FIX cDNA safely and efficiently cure hemophilia B in a mouse model.
Journal ArticleDOI
IL-6 receptor antagonist as adjunctive therapy with clotting factor replacement to protect against bleeding-induced arthropathy in hemophilia
Nattee Narkbunnam,Junjiang Sun,Genlin Hu,Feng-Chang Lin,Ted A. Bateman,Masahiko Mihara,Paul E. Monahan +6 more
TL;DR: Specific therapies to oppose inflammatory cytokines, including Interleukin 6 (IL‐6) receptor antagonists, have become important in the management of inflammatory arthritides.
Journal ArticleDOI
A Retrospective Study of the Cytokine Profile Changes in Mice with FVIII Inhibitor Development After Adeno-Associated Virus-Mediated Gene Therapy in a Hemophilia A Mouse Model.
Junjiang Sun,Zhenhua Yuan,Yasmina L. Abajas,Doreen E. Szollosi,Genlin Hu,Baolai Hua,Xiao Xiao,Chengwen Li +7 more
TL;DR: The study of cytokine profile changes during FVIII inhibitor development may be helpful to understand the mechanism of inhibitor development and to explore potential novel approaches that will minimize the risk.