Georg K. A. Hochberg

TL;DR: UniDec (Universal Deconvolution), software that provides a rapid, robust, and flexible deconvolution of mass spectra and ion mobility-mass spectra with minimal user intervention is developed, using systems of increasing complexity.

TL;DR: It is found that the core domain of the human molecular chaperone αB-crystallin can function effectively in preventing protein aggregation and amyloid toxicity, and is designed as an equivalently locked cABC to investigate the functional role played by oligomerization, disordered N and C termini, subunit exchange, and variable dimer interfaces in ABC.

TL;DR: In this article, the core domain of the human molecular chaperone αB-crystallin can function effectively in preventing protein aggregation and amyloid toxicity, and the structures of these domains that are presented should represent useful scaffolds for the design of novel AMyloid inhibitors.

TL;DR: Recent studies employing ancestral protein reconstruction are reviewed and it is shown how they have produced new knowledge not only of molecular evolutionary processes but also of the underlying determinants of modern proteins' physical, chemical, and biological properties.

TL;DR: This work establishes an approach for linking protein components into robust, higher-order structures, and expands the design space available for supramolecular assemblies to include previously unexplored geometries, and displays excellent chemical and thermal stability.