J
Jonathan G. Heddle
Researcher at Jagiellonian University
Publications - 77
Citations - 1958
Jonathan G. Heddle is an academic researcher from Jagiellonian University. The author has contributed to research in topics: DNA gyrase & DNA supercoil. The author has an hindex of 24, co-authored 68 publications receiving 1567 citations. Previous affiliations of Jonathan G. Heddle include Tokyo Institute of Technology & Nara Institute of Science and Technology.
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Journal ArticleDOI
Crystal Structure of Hemoglobin Protease, a Heme Binding Autotransporter Protein from Pathogenic Escherichia coli
Ben R. Otto,Robert Sijbrandi,Joen Luirink,Bauke Oudega,Jonathan G. Heddle,Kenji Mizutani,Sam-Yong Park,Jeremy R. H. Tame +7 more
TL;DR: The crystal structure of the complete passenger domain of Hbp (110 kDa) is presented, which is the first structure from this class of serine proteases and the largest parallel β-helical structure yet solved.
Journal ArticleDOI
The antibiotic microcin B17 is a DNA gyrase poison: characterisation of the mode of inhibition.
Jonathan G. Heddle,Jonathan G. Heddle,Stephen J. Blance,Deborah B. Zamble,Florian Hollfelder,Deborah Ann Miller,Lois M. Wentzell,Christopher T. Walsh,Anthony Maxwell,Anthony Maxwell +9 more
TL;DR: In the presence of ATP, or the non-hydrolysable analogue 5′-adenylyl β,γ-imidodiphosphate, microcin B17 stabilises a gyrase-dependent DNA cleavage complex in a manner reminiscent of quinolones, Ca2+, or the bacterial toxin CcdB as mentioned in this paper.
Journal ArticleDOI
An ultra-stable gold-coordinated protein cage displaying reversible assembly.
Ali D. Malay,Naoyuki Miyazaki,Artur Biela,Soumyananda Chakraborti,Karolina Majsterkiewicz,Izabela Stupka,Craig S. Kaplan,Agnieszka Kowalczyk,Bernard Piette,Georg K. A. Hochberg,Georg K. A. Hochberg,Di Wu,Tomasz P. Wrobel,Adam Fineberg,Manish S. Kushwah,Mitja Kelemen,Primož Vavpetič,Primož Pelicon,Philipp Kukura,Justin L. P. Benesch,Kenji Iwasaki,Kenji Iwasaki,Jonathan G. Heddle +22 more
TL;DR: This work establishes an approach for linking protein components into robust, higher-order structures, and expands the design space available for supramolecular assemblies to include previously unexplored geometries, and displays excellent chemical and thermal stability.
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Quinolone-Binding Pocket of DNA Gyrase: Role of GyrB
TL;DR: DNA gyrase is a prokaryotic type II topoisomerase and a major target of quinolone antibacterials, and large conformational changes during the catalytic cycle of the enzyme allow these regions to come into close proximity.
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Crystal structures of the liganded and unliganded nickel-binding protein NikA from Escherichia coli.
TL;DR: This work has solved the crystal structure of NikA protein in the presence and absence of nickel, showing that it behaves as a “classical” periplasmic binding protein.