Manish S. Kushwah

TL;DR: This work establishes an approach for linking protein components into robust, higher-order structures, and expands the design space available for supramolecular assemblies to include previously unexplored geometries, and displays excellent chemical and thermal stability.

TL;DR: In this article, the authors demonstrate dynamic mass photometry, a method for label-free imaging, tracking and mass measurement of individual membrane-associated proteins diffusing on supported lipid bilayers.

TL;DR: In this paper, a 3D reconstruction of human linear ubiquitin chain assembly complex (LUBAC) was obtained by electron microscopy and reported its generation of heterotypic chains containing linear linkages with oxyester-linked branches.

TL;DR: In this article, a single molecule mass photometry quantifies affinity and polydispersity of heterogeneous protein complexes in solution, and the authors demonstrate these capabilities by studying the functionally relevant 2-cysteine peroxiredoxins (2CPs).

TL;DR: In this paper, single molecule mass photometry was used to study the dynamic equilibria of the ubiquitous and highly abundant 2-Cysteine peroxiredoxins (2-CysPRX).