S
Sung Bau Lee
Researcher at Taipei Medical University
Publications - 16
Citations - 939
Sung Bau Lee is an academic researcher from Taipei Medical University. The author has contributed to research in topics: Chromatin & Promoter. The author has an hindex of 11, co-authored 16 publications receiving 785 citations. Previous affiliations of Sung Bau Lee include University of Copenhagen & Academia Sinica.
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Journal ArticleDOI
Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components
Constance Alabert,Jimi-Carlo Bukowski-Wills,Sung Bau Lee,Georg Kustatscher,Kyosuke Nakamura,Flavia de Lima Alves,Patrice Menard,Jakob Mejlvang,Juri Rappsilber,Juri Rappsilber,Anja Groth +10 more
TL;DR: This work uses nascent chromatin capture (NCC) to profile chromatin proteome dynamics during replication in human cells, and identifies FAM111A as a replication factor required for PCNA loading, providing an extensive resource to understand genome and epigenome maintenance.
Journal ArticleDOI
TET1 Suppresses Cancer Invasion by Activating the Tissue Inhibitors of Metalloproteinases
Chih-Hung Hsu,Kai-Lin Peng,Kai-Lin Peng,Ming-Lun Kang,Yi-Ren Chen,Yu-Chih Yang,Chin-Hsien Tsai,Chin-Hsien Tsai,Chi-Shuen Chu,Chi-Shuen Chu,Yung-Ming Jeng,Yen-Ting Chen,Yen-Ting Chen,Feng Mao Lin,Hsien Da Huang,Yun-Yuh Lu,Yu-Ching Teng,Yu-Ching Teng,Shinn-Tsuen Lin,Ruo Kai Lin,Fan-Mei Tang,Sung Bau Lee,Huan Ming Hsu,Jyh-Cherng Yu,Pei-Wen Hsiao,Li-Jung Juan,Li-Jung Juan,Li-Jung Juan +27 more
TL;DR: It is shown that TET1, a dioxygenase involved in cytosine demethylation, is downregulated in prostate and breast cancer tissues, illustrating a mechanism by which TET 1 suppresses tumor development and invasion partly through downregulation of critical gene methylation.
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hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing
Chung Fan Lee,Derick S. C. Ou,Derick S. C. Ou,Sung Bau Lee,Liang Hao Chang,Ruo Kai Lin,Ying Shiuan Li,Anup K. Upadhyay,Xiaodong Cheng,Yi Ching Wang,Han Shui Hsu,Michael Hsiao,Cheng-Wen Wu,Li-Jung Juan,Li-Jung Juan +14 more
TL;DR: The data not only establish hNaa10p as an oncoprotein, but also reveal that it contributes to oncogenesis through modulation of DNMT1 function.
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BRPF3‐HBO1 regulates replication origin activation and histone H3K14 acetylation
Yunpeng Feng,Arsenios Vlassis,Céline Roques,Marie-Eve Lalonde,Cristina González-Aguilera,Jean-Philippe Lambert,Sung Bau Lee,Xiaobei Zhao,Constance Alabert,Jens Vilstrup Johansen,Eric Paquet,Xiang-Jiao Yang,Anne-Claude Gingras,Jacques Côté,Anja Groth +14 more
TL;DR: It is proposed that BRPF3‐HBO1 acetylation of histone H3K14 around TSS facilitates efficient activation of nearby replication origins, complementary to its role in licencing.
Journal ArticleDOI
Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors
Sung Bau Lee,Sung Bau Lee,Sandra Segura-Bayona,Marina Villamor-Payà,Giulia Saredi,Matthew A.M. Todd,Camille Stephan-Otto Attolini,Ting Yu Chang,Travis H. Stracker,Anja Groth +9 more
TL;DR: A critical role for TLKs in chromatin replication and suppression of replication stress is revealed and a synergistic lethal relationship with checkpoint signaling and PARP that could be exploited in treatment of a broad range of cancers is identified.