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Jakob Mejlvang

Researcher at University of Tromsø

Publications -  7
Citations -  2080

Jakob Mejlvang is an academic researcher from University of Tromsø. The author has contributed to research in topics: Histone code & Control of chromosome duplication. The author has an hindex of 7, co-authored 7 publications receiving 1035 citations. Previous affiliations of Jakob Mejlvang include University of Copenhagen.

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components

TL;DR: This work uses nascent chromatin capture (NCC) to profile chromatin proteome dynamics during replication in human cells, and identifies FAM111A as a replication factor required for PCNA loading, providing an extensive resource to understand genome and epigenome maintenance.
Journal ArticleDOI

Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption

TL;DR: It is suggested that deregulated CDK activity, such as that occurring following inhibition of WEE1 kinase or activation of oncogenes, induces replication stress and loss of genomic integrity through increased firing of replication origins and subsequent nucleotide shortage.
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Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy.

TL;DR: Qualitative proteomics data support a model in which amino acid deprivation elicits endocytosis of specific membrane receptors, induction of macroautophagy, and rapid degradation of autophagy receptors by endosomal microautophagic.
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New histone supply regulates replication fork speed and PCNA unloading

TL;DR: Coupling of replication fork speed and PCNA unloading to nucleosome assembly may maintain chromatin integrity during transient histone shortage.