Georg Luxenhofer

TL;DR: It is shown that trafficking of reggie-1/flotillin-2 is BFA sensitive and that deletion mutants of reggies/ flotillins accumulate in the Golgi complex in HeLa, Jurkat and PC12 cells, suggesting Golgi-dependent trafficking ofreggie- 1/flotsillins-2.

TL;DR: It is demonstrated that the transcriptional activators of the Onecut family critically regulate MN subtype diversification during spinal cord development and Sip1 (Zeb2) is identified as a novel developmental regulator of visceral MN differentiation.

TL;DR: In this paper, a trans-negative reggie-1/flotillin-2 deletion mutant, R1EA, was found to interfere with oligomerization of the reggies and flotillins, inhibited insulin-like growth factor (IGF)-induced neurite outgrowth in N2a neuroblastoma cells and impaired in vitro differentiation of primary rat hippocampal neurons.

TL;DR: The data suggest that amino and phosphate surface modifications, but not polyethylene glycol (PEG), mitigate the proinflammatory and immunomodulatory effect of SiO2 NPs in allergic airway inflammation, paving the way for new strategies in the production of nanomaterials with lower health impact for humans.

TL;DR: The preformed reggie/flotillin caps are stable priming platforms for the assembly of multiprotein complexes controlling actin reorganization during T cell activation.