G
George L. Mutter
Researcher at Brigham and Women's Hospital
Publications - 147
Citations - 11589
George L. Mutter is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Endometrial intraepithelial neoplasia & Endometrial cancer. The author has an hindex of 55, co-authored 145 publications receiving 10954 citations. Previous affiliations of George L. Mutter include NewYork–Presbyterian Hospital & Case Western Reserve University.
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Journal ArticleDOI
Altered PTEN Expression as a Diagnostic Marker for the Earliest Endometrial Precancers
George L. Mutter,Ming Chieh Lin,Jeffrey T. Fitzgerald,Jennifer B. Kum,Jan P. A. Baak,Jacqueline A. Lees,Liang Ping Weng,Charis Eng +7 more
TL;DR: Loss of PTEN function by mutational or other mechanisms is an early event in endometrial tumorigenesis that may occur in response to known endocrine risk factors and offers an informative immunohistochemical biomarker for premalignant disease.
Journal ArticleDOI
Molecular and Pathologic Aspects of Endometrial Carcinogenesis
TL;DR: The precursor lesion of type I endometrioid cancer and the role of genetics and estrogen in its progression are defined and the genetic aspects of endometrial carcinogenesis and progression are reviewed.
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A compendium of gene expression in normal human tissues.
Li Li Hsiao,Fernando Dangond,Takumi Yoshida,Robert L. Hong,Roderick V. Jensen,Jatin Misra,William P. Dillon,Kailin F. Lee,Kathryn E. Clark,Peter M. Haverty,Zhiping Weng,George L. Mutter,Matthew P. Frosch,Marcy E. MacDonald,Edgar L. Milford,Christopher P. Crum,Raphael Bueno,Richard E. Pratt,Mamatha Mahadevappa,Janet A. Warrington,Gregory Stephanopoulos,George Stephanopoulos,Steven R. Gullans +22 more
TL;DR: A compendium of gene expression in normal human tissues suitable as a reference for defining basic organ systems biology is created and subsets of tissue-selective genes are identified that define key biological processes characterizing each organ.
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Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages.
TL;DR: It is shown that GF-1 is expressed in two other haematopoietic lineages, megakaryocytes and bone marrow-derived mast cells, and these findings are consistent with results from haem atopoetic progenitor culture which suggest a relationship between erythroid,Megakaryocytic and mast cell lineages and imply thatGF-1 was expressed in committed multipotential cells and their progeny.
Journal ArticleDOI
Immunohistochemical Evidence of Loss of PTEN Expression in Primary Ductal Adenocarcinomas of the Breast
Aurel Perren,Liang Ping Weng,Alexander Boag,Ulricke Ziebold,Kosha Thakore,Kosha Thakore,Patricia L. M. Dahia,Patricia L. M. Dahia,Paul Komminoth,Jacqueline A. Lees,Lois M. Mulligan,George L. Mutter,Charis Eng,Charis Eng +13 more
TL;DR: PTEN expression was analyzed in 33 sporadic primary breast carcinoma samples using immunohistochemistry and correlated this to structural studies at the molecular level, finding that an epigenetic phenomenon such as hypermethylation, -ecreased protein synthesis or increased protein degradation may be involved.