Fernando Dangond

TL;DR: A compendium of gene expression in normal human tissues suitable as a reference for defining basic organ systems biology is created and subsets of tissue-selective genes are identified that define key biological processes characterizing each organ.

TL;DR: Findings indicate that an early event in the initiation of MS involves upregulation of B7-1 and IL-12, resulting in conditions that maximally stimulate T cell activation and induction of T helper 1-type immune responses.

TL;DR: Evidence is provided that the pharmacological induction of NF‐κB‐dependent transcription and bcl‐2 gene expression is neuroprotective in ALS mice by inhibiting programmed cell death and Phenylbutyrate may provide a novel therapeutic approach for the treatment of patients with ALS.

TL;DR: It is demonstrated that the histone deacetylase (HDAC) inhibitor drug trichostatin A (TSA) reduces spinal cord inflammation, demyelination, neuronal and axonal loss and ameliorates disability in the relapsing phase of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS).

TL;DR: Cladribine tablets treatment for 2’ years followed by 2 years’ placebo treatment produced durable clinical benefits similar to 4’years of cladribine treatment with a low risk of severe lymphopenia or clinical worsening.