M
Michael R Hübner
Researcher at European Bioinformatics Institute
Publications - 5
Citations - 2472
Michael R Hübner is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Promoter & General transcription factor. The author has an hindex of 5, co-authored 5 publications receiving 2421 citations.
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Journal ArticleDOI
Estrogen Receptor-α Directs Ordered, Cyclical, and Combinatorial Recruitment of Cofactors on a Natural Target Promoter
Raphaël Métivier,Graziella Penot,Michael R Hübner,George Reid,Heike Brand,Martin Kos,Frank Gannon +6 more
TL;DR: A comprehensive picture of events resulting in transcriptional activation of a gene is provided, through evaluating the estrogen receptor-alpha (NR3A1) target pS2 gene promoter in MCF-7 cells, which implies that transcriptionalactivation is a cyclical process that requires both activating and repressive epigenetic processes.
Journal ArticleDOI
Cyclic, Proteasome-Mediated Turnover of Unliganded and Liganded ERα on Responsive Promoters Is an Integral Feature of Estrogen Signaling
George Reid,Michael R Hübner,Raphaël Métivier,Heike Brand,Stefanie Denger,Dominique Manu,Joël Beaudouin,Jan Ellenberg,Frank Gannon +8 more
TL;DR: It is demonstrated that proteasome-mediated degradation and hER alpha-mediated transactivation are inherently linked and act to continuously turn over hERalpha on responsive promoters.
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A Dynamic Structural Model for Estrogen Receptor-α Activation by Ligands, Emphasizing the Role of Interactions between Distant A and E Domains
Raphaël Métivier,Alexander Stark,Gilles Flouriot,Michael R Hübner,Heike Brand,Graziella Penot,Graziella Penot,Dominique Manu,Stefanie Denger,George Reid,Martin Kos,Robert B. Russell,Olivier Kah,Farzad Pakdel,Frank Gannon +14 more
TL;DR: A dynamic model where binding of different ligands influences the A/D-F domain interaction and results in specific functional outcomes is proposed, which gives insights into the dynamic properties of full-length ERalpha and into the structure of unliganded ERalpha.
Journal ArticleDOI
Transcriptional complexes engaged by apo-estrogen receptor-α isoforms have divergent outcomes
Raphaël Métivier,Raphaël Métivier,Graziella Penot,Graziella Penot,Richard P. Carmouche,Michael R Hübner,George Reid,Stefanie Denger,Dominique Manu,Heike Brand,Martin Kos,Vladimir Benes,Frank Gannon +12 more
TL;DR: The maintenance of a promoter in a repressed state as a cyclical process that is intrinsically dependent on initial poising of the promoter is depicted.
Journal ArticleDOI
Formation of an hERα–COUP-TFI complex enhances hERα AF-1 through Ser118 phosphorylation by MAPK
Raphaël Métivier,Raphaël Métivier,Michael R Hübner,Gilles Flouriot,Gilles Salbert,Frank Gannon,Olivier Kah,Farzad Pakdel +7 more
TL;DR: The enhancement of the human estrogen receptor α (hERα, NR3A1) activity by the orphan nuclear receptor COUP‐TFI is found to depend on the establishment of a tight hERα–COUP‐ TFI complex, and an alternative interaction process between nuclear receptors is indicated.