G
Georges K. Christophides
Researcher at Imperial College London
Publications - 5
Citations - 1120
Georges K. Christophides is an academic researcher from Imperial College London. The author has contributed to research in topics: Gene & Gene expression profiling. The author has an hindex of 4, co-authored 5 publications receiving 1057 citations. Previous affiliations of Georges K. Christophides include European Bioinformatics Institute.
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Journal ArticleDOI
A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses
Neil Hall,Marianna Karras,J. Dale Raine,Jane M. Carlton,Jane M. Carlton,Jane M. Carlton,Taco W. A. Kooij,Matthew Berriman,Laurence Florens,Christoph S. Janssen,Arnab Pain,Georges K. Christophides,Keith D. James,Kim Rutherford,Barbara Harris,David Harris,Carol Churcher,Michael A. Quail,Doug Ormond,Jon Doggett,Holly E. Trueman,Jacqui Mendoza,Shelby L. Bidwell,Marie Adele Rajandream,Daniel J. Carucci,John R. Yates,Fotis C. Kafatos,Chris J. Janse,Bart Barrell,C. Michael R. Turner,Andrew P. Waters,Robert E. Sinden +31 more
TL;DR: It is observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3′ untranslated region motif is implicated in this process.
Journal ArticleDOI
Gene knockdown by RNAi in the pea aphid Acyrthosiphon pisum.
Stéphanie Jaubert-Possamai,Gaël Le Trionnaire,Joël Bonhomme,Georges K. Christophides,Claude Rispe,Denis Tagu +5 more
TL;DR: The pea aphid is the first Hemipteran insect for which genome sequence will be available soon and the gene knockdown technique developed in this study will be an essential post-genomic tool for further investigations in aphidology.
Journal ArticleDOI
Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility.
Arthur M. Talman,Arthur M. Talman,Judith Helena Prieto,Judith Helena Prieto,Sara R. Marques,Ceereena Ubaida-Mohien,Mara K. N. Lawniczak,Mark N. Wass,Mark N. Wass,Tao Xu,Tao Xu,Roland Frank,Andrea Ecker,Rebecca Limenitakis Stanway,Rebecca Limenitakis Stanway,Sanjeev Krishna,Michael J.E. Sternberg,Georges K. Christophides,David R. Graham,Rhoel R. Dinglasan,John R. Yates,Robert E. Sinden +21 more
TL;DR: This study describes the first whole-cell proteomic analysis of the malaria male gamete and identifies glycolysis as the likely exclusive source of energy for flagellar beat, and provides new insights in original features of Plasmodium flagllar organization.
Journal ArticleDOI
Melanotic Pathology and Vertical Transmission of the Gut Commensal Elizabethkingia meningoseptica in the Major Malaria Vector Anopheles gambiae
TL;DR: It is shown that E . meningoseptica can be vertically transmitted from eggs to larvae and that E -mono-associated mosquitoes display significant mortality, which is further enhanced upon Plasmodium infection, suggesting a synergistic impact of E .MeningosePTica and PlasModium on mosquito survival.
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Anopheles arabiensis hotspots along intermittent rivers drive malaria dynamics in semi-arid areas of Central Ethiopia.
TL;DR: In this article, the seasonal spatio-temporal dynamics of the malaria vector population and transmission intensity along intermittent rivers in a semi-arid area of central Ethiopia were investigated.