J
J. Dale Raine
Researcher at Imperial College London
Publications - 6
Citations - 3063
J. Dale Raine is an academic researcher from Imperial College London. The author has contributed to research in topics: Plasmodium berghei & Plasmodium falciparum. The author has an hindex of 6, co-authored 6 publications receiving 2967 citations. Previous affiliations of J. Dale Raine include Scripps Research Institute & J. Craig Venter Institute.
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Journal ArticleDOI
A proteomic view of the Plasmodium falciparum life cycle
Laurence Florens,Michael P. Washburn,J. Dale Raine,Robert M. Anthony,Munira Grainger,J. David Haynes,J. David Haynes,J. Kathleen Moch,Nemone Muster,John B. Sacci,John B. Sacci,David L. Tabb,David L. Tabb,Adam A. Witney,Adam A. Witney,Dirk Wolters,Dirk Wolters,Yimin Wu,Malcolm J. Gardner,Anthony A. Holder,Robert E. Sinden,John R. Yates,John R. Yates,Daniel J. Carucci +23 more
TL;DR: A high-throughput proteomics approach was applied to identify new potential drug and vaccine targets and to better understand the biology of this complex protozoan parasite.
Journal ArticleDOI
A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses
Neil Hall,Marianna Karras,J. Dale Raine,Jane M. Carlton,Jane M. Carlton,Jane M. Carlton,Taco W. A. Kooij,Matthew Berriman,Laurence Florens,Christoph S. Janssen,Arnab Pain,Georges K. Christophides,Keith D. James,Kim Rutherford,Barbara Harris,David Harris,Carol Churcher,Michael A. Quail,Doug Ormond,Jon Doggett,Holly E. Trueman,Jacqui Mendoza,Shelby L. Bidwell,Marie Adele Rajandream,Daniel J. Carucci,John R. Yates,Fotis C. Kafatos,Chris J. Janse,Bart Barrell,C. Michael R. Turner,Andrew P. Waters,Robert E. Sinden +31 more
TL;DR: It is observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3′ untranslated region motif is implicated in this process.
Journal ArticleDOI
Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii
Jane M. Carlton,Samuel V. Angiuoli,Bernard B. Suh,Taco W. A. Kooij,Mihaela Pertea,Joana C. Silva,Maria D. Ermolaeva,Jonathan E. Allen,Jeremy D. Selengut,Hean L. Koo,Jeremy Peterson,Mihai Pop,Daniel S. Kosack,Martin Shumway,Shelby L. Bidwell,Shamira J. Shallom,Susan Van Aken,Steven B. Riedmuller,Tamara Feldblyum,Jennifer Cho,John Quackenbush,Martha Sedegah,Azadeh Shoaibi,Leda M. Cummings,Laurence Florens,John R. Yates,J. Dale Raine,Robert E. Sinden,Michael Harris,Deirdre A. Cunningham,Peter R. Preiser,Lawrence W. Bergman,Akhil B. Vaidya,Leo H.M. van Lin,Chris J. Janse,Andrew P. Waters,Hamilton O. Smith,Owen White,Steven L. Salzberg,J. Craig Venter,Claire M. Fraser,Stephen L. Hoffman,Malcolm J. Gardner,Daniel J. Carucci +43 more
TL;DR: This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease.
Journal ArticleDOI
Proteome analysis of rhoptry-enriched fractions isolated from Plasmodium merozoites.
Tobili Y. Sam-Yellowe,Laurence Florens,Tongmin Wang,J. Dale Raine,Daniel J. Carucci,Robert Sinden,John R. Yates +6 more
TL;DR: Molecular characterization and understanding of the supramolecular organization of these novel potential rhoptry proteins may assist in the identification of new intervention targets for the asexual blood stages of malaria.
Journal ArticleDOI
Female Inheritance of Malarial lap Genes Is Essential for Mosquito Transmission
TL;DR: It is concluded that the functions of PbLAPs1, 2, 4, and 6 are critical prior to the expression of the male-derived gene after microgametogenesis, fertilization, and meiosis, possibly in the gametocyte-to-ookinete period of differentiation.