F
Fotis C. Kafatos
Researcher at Imperial College London
Publications - 70
Citations - 16999
Fotis C. Kafatos is an academic researcher from Imperial College London. The author has contributed to research in topics: Anopheles gambiae & Plasmodium berghei. The author has an hindex of 48, co-authored 70 publications receiving 16254 citations. Previous affiliations of Fotis C. Kafatos include Harvard University & GlaxoSmithKline.
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Journal ArticleDOI
Phylogenetic Perspectives in Innate Immunity
TL;DR: In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.
Journal ArticleDOI
The Genome Sequence of the Malaria Mosquito Anopheles gambiae
Robert A. Holt,G. Mani Subramanian,Aaron L. Halpern,Granger G. Sutton,Rosane Charlab,Deborah R. Nusskern,Patrick Wincker,Andrew G. Clark,José M. C. Ribeiro,Ron Wides,Steven L. Salzberg,Brendan J. Loftus,Mark Yandell,William H. Majoros,William H. Majoros,Douglas B. Rusch,Zhongwu Lai,Cheryl L. Kraft,Josep F. Abril,Véronique Anthouard,Peter Arensburger,Peter W. Atkinson,Holly Baden,Véronique de Berardinis,Danita Baldwin,Vladimir Benes,Jim Biedler,Claudia Blass,Randall Bolanos,Didier Boscus,Mary Barnstead,Shuang Cai,Kabir Chatuverdi,George K. Christophides,Mathew A. Chrystal,Michele Clamp,Anibal Cravchik,Val Curwen,Ali N Dana,Arthur L. Delcher,Ian M. Dew,Cheryl A. Evans,Michael Flanigan,Anne Grundschober-Freimoser,Lisa Friedli,Zhiping Gu,Ping Guan,Roderic Guigó,Maureen E. Hillenmeyer,Susanne L. Hladun,James R. Hogan,Young S. Hong,Jeffrey Hoover,Olivier Jaillon,Zhaoxi Ke,Zhaoxi Ke,Chinnappa D. Kodira,Kokoza Eb,Anastasios C. Koutsos,Ivica Letunic,Alex Levitsky,Yong Liang,Jhy-Jhu Lin,Jhy-Jhu Lin,Neil F. Lobo,John Lopez,Joel A. Malek,Tina C. McIntosh,Stephan Meister,Jason R. Miller,Clark M. Mobarry,Emmanuel Mongin,Sean D. Murphy,David A. O'Brochta,Cynthia Pfannkoch,Rong Qi,Megan A. Regier,Karin A. Remington,Hongguang Shao,Maria V. Sharakhova,Cynthia Sitter,Jyoti Shetty,Thomas J. Smith,Renee Strong,Jingtao Sun,Dana Thomasova,Lucas Q. Ton,Pantelis Topalis,Zhijian Tu,Maria F. Unger,Brian P. Walenz,Aihui Wang,Jian Wang,Mei Wang,X. Wang,Kerry J. Woodford,Jennifer R. Wortman,Jennifer R. Wortman,Martin Wu,Alison Yao,Evgeny M. Zdobnov,Hongyu Zhang,Qi Zhao,Shaying Zhao,Shiaoping C. Zhu,Igor F. Zhimulev,Mario Coluzzi,Alessandra della Torre,Charles Roth,Christos Louis,Francis Kalush,Richard J. Mural,Eugene W. Myers,Mark Raymond Adams,Hamilton O. Smith,Samuel Broder,Malcolm J. Gardner,Claire M. Fraser,Ewan Birney,Peer Bork,Paul T. Brey,J. Craig Venter,J. Craig Venter,Jean Weissenbach,Fotis C. Kafatos,Frank H. Collins,Stephen L. Hoffman +126 more
TL;DR: Analysis of the PEST strain of A. gambiae revealed strong evidence for about 14,000 protein-encoding transcripts, and prominent expansions in specific families of proteins likely involved in cell adhesion and immunity were noted.
Journal ArticleDOI
Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure
TL;DR: A dot hybridization method is presented for rapidly determining the relative concentrations of nucleic acids in a mixture, as well as the extent of sequence homology between related RNA or DNA species.
Journal ArticleDOI
Immunity-Related Genes and Gene Families in Anopheles gambiae
George K. Christophides,Evgeny M. Zdobnov,Carolina Barillas-Mury,Ewan Birney,Stéphanie Blandin,Claudia Blass,Paul T. Brey,Frank H. Collins,Alberto Danielli,George Dimopoulos,Charles Hetru,Ngo Thi Hoa,Jules A. Hoffmann,Stefan M. Kanzok,Ivica Letunic,Elena A. Levashina,Thanasis G. Loukeris,Gareth J Lycett,Stephan Meister,Kristin Michel,Luis F. Moita,Hans-Michael Müller,Mike A. Osta,Susan M. Paskewitz,Jean-Marc Reichhart,Andrey Rzhetsky,Laurent Troxler,Kenneth D. Vernick,Dina Vlachou,Jennifer Volz,Christian von Mering,Jiannong Xu,Liangbiao Zheng,Peer Bork,Fotis C. Kafatos +34 more
TL;DR: 242 Anopheles gambiae genes from 18 gene families implicated in innate immunity are identified and marked diversification relative to Drosophila melanogaster is detected, confirming that sequence diversification is accompanied by specific responses to different immune challenges.
Journal ArticleDOI
A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses
Neil Hall,Marianna Karras,J. Dale Raine,Jane M. Carlton,Jane M. Carlton,Jane M. Carlton,Taco W. A. Kooij,Matthew Berriman,Laurence Florens,Christoph S. Janssen,Arnab Pain,Georges K. Christophides,Keith D. James,Kim Rutherford,Barbara Harris,David Harris,Carol Churcher,Michael A. Quail,Doug Ormond,Jon Doggett,Holly E. Trueman,Jacqui Mendoza,Shelby L. Bidwell,Marie Adele Rajandream,Daniel J. Carucci,John R. Yates,Fotis C. Kafatos,Chris J. Janse,Bart Barrell,C. Michael R. Turner,Andrew P. Waters,Robert E. Sinden +31 more
TL;DR: It is observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3′ untranslated region motif is implicated in this process.