J
Jacobus Slabbert
Researcher at National Research Foundation of South Africa
Publications - 18
Citations - 408
Jacobus Slabbert is an academic researcher from National Research Foundation of South Africa. The author has contributed to research in topics: Radiosensitivity & Breast cancer. The author has an hindex of 9, co-authored 18 publications receiving 341 citations. Previous affiliations of Jacobus Slabbert include Stellenbosch University.
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Journal ArticleDOI
Automated micronucleus (MN) scoring for population triage in case of large scale radiation events.
Petra Willems,Liezel August,Jacobus Slabbert,Horst Romm,Ursula Oestreicher,Hubert Thierens,Anne Vral +6 more
TL;DR: These results confirm the efficacy of the automated MN assay for fast population triage in a multicenter setting, in the case of large radiation accidents, with close correlation with MN yields obtained with the manual procedure.
Journal ArticleDOI
RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA).
Ursula Oestreicher,Daniel Samaga,Elizabeth A. Ainsbury,Ana Antunes,Ans Baeyens,Leonardo Barrios,Christina Beinke,P. Beukes,William F. Blakely,Alexandra Cucu,Andrea De Amicis,Julie Depuydt,Stefania De Sanctis,Marina Di Giorgio,Katalin Dobos,Inmaculada Domínguez,Pham Ngoc Duy,Marco E. Espinoza,Farrah Flegal,Markus Figel,Omar García,Octávia Monteiro Gil,Eric Gregoire,C. Guerrero-Carbajal,I. Guclu,Valeria Hadjidekova,M. Prakash Hande,Ulrike Kulka,Jennifer A. Lemon,Carita Lindholm,Florigio Lista,Katalin Lumniczky,Wilner Martínez-López,Nataliya A. Maznyk,Roberta Meschini,Radia M’kacher,Alegría Montoro,Jayne Moquet,Mercedes Moreno,Mihaela Noditi,J. Pajic,Analía Radl,Michelle Ricoul,Horst Romm,Laurence Roy,Laure Sabatier,Natividad Sebastià,Jacobus Slabbert,Sylwester Sommer,Monica Stuck Oliveira,Uma Subramanian,Yumiko Suto,Tran Que,Antonella Testa,Georgia I. Terzoudi,Anne Vral,Ruth C. Wilkins,LusiYanti Yanti,D. Zafiropoulos,Andrzej Wojcik +59 more
TL;DR: In case of a large-scale radiological incident, the pooling of ressources by networks can enhance the rapid classification of individuals in medically relevant treatment groups based on the DCA.
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RENEB intercomparison exercises analyzing micronuclei (Cytokinesis-block Micronucleus Assay)
Julie Depuydt,Ans Baeyens,Stephen Barnard,Christina Beinke,Anett Benedek,P. Beukes,Iwona Buraczewska,Firouz Darroudi,Stefania De Sanctis,Inmaculada Domínguez,Octávia Monteiro Gil,Valeria Hadjidekova,Enikő Kis,Ulrike Kulka,Florigio Lista,Katalin Lumniczky,Radhia M'kacher,Jayne Moquet,Doina Obreja,Ursula Oestreicher,J. Pajic,Nuria Pastor,Ljubomira Popova,Elisa Regalbuto,Michelle Ricoul,Laure Sabatier,Jacobus Slabbert,Sylwester Sommer,Antonella Testa,Hubert Thierens,Andrzej Wojcik,Anne Vral +31 more
TL;DR: The results of the two exercises performed by the RENEB network demonstrate that the micronucleus assay is a useful tool for large-scale radiation emergencies, and can be successfully implemented within a large network of laboratories.
Journal ArticleDOI
BRCA1, BRCA2 and PALB2 mutations and CHEK2 c.1100delC in different South African ethnic groups diagnosed with premenopausal and/or triple negative breast cancer.
Flavia Zita Francies,Flavia Zita Francies,Tasha Wainstein,K De Leeneer,A. Cairns,Marshall Murdoch,Sarah Nietz,H. Cubasch,Bruce Poppe,T. Van Maerken,Brecht Crombez,Ilse Coene,Robyn Kerr,Jacobus Slabbert,Anne Vral,Amanda Krause,Ans Baeyens,Ans Baeyens,Ans Baeyens,Kathleen Claes +19 more
TL;DR: This NGS study shows that mutation analysis is warranted in South African patients with triple negative and/or in premenopausal breast cancer, and highlights the importance of evaluating germline mutations in major breast cancer genes in all of the South African population groups.
Journal ArticleDOI
The radiosensitizing effect of Ku70/80 knockdown in MCF10A cells irradiated with X-rays and p(66)+Be(40) neutrons.
Veerle Vandersickel,Monica Mancini,Jacobus Slabbert,Emanuela Marras,Hubert Thierens,Gianpaolo Perletti,Anne Vral +6 more
TL;DR: Interfering with the NHEJ pathway enhanced the radiosensitivity of human MCF10A cells to low-LET X-rays and high-LET neutrons, pointing to the importance of the Ku heterodimer for repairing damage induced by both types of radiation.