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Anthony Siau
Researcher at Pierre-and-Marie-Curie University
Publications - 7
Citations - 679
Anthony Siau is an academic researcher from Pierre-and-Marie-Curie University. The author has contributed to research in topics: Plasmodium falciparum & Plasmodium. The author has an hindex of 6, co-authored 6 publications receiving 640 citations. Previous affiliations of Anthony Siau include French Institute of Health and Medical Research.
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Journal ArticleDOI
A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites.
Olivier Silvie,Jean-François Franetich,Stéphanie Charrin,Markus S. Mueller,Anthony Siau,Myriam Bodescot,Eric Rubinstein,Laurent Hannoun,Yupin Charoenvit,Clemens H. M. Kocken,Alan W. Thomas,Geert-Jan van Gemert,Robert W. Sauerwein,Michael J. Blackman,Robin F. Anders,Gerd Pluschke,Dominique Mazier +16 more
TL;DR: Investigation of the expression and function of another microneme protein recently identified in Plasmodium falciparum sporozoites, apical membrane antigen 1 (AMA-1), finds that interfering with sporozoite proteolytic processing may constitute a valuable strategy to prevent hepatocyte infection.
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Scavenger Receptor BI Boosts Hepatocyte Permissiveness to Plasmodium Infection
Samir Yalaoui,Thierry Huby,Thierry Huby,Jean-François Franetich,Jean-François Franetich,Audrey Gego,Audrey Gego,Armelle Rametti,Armelle Rametti,Martine Moreau,Martine Moreau,Xavier Collet,Xavier Collet,Anthony Siau,Anthony Siau,Geert-Jan van Gemert,Robert W. Sauerwein,Adrian J. F. Luty,Jean-Christophe Vaillant,Laurent Hannoun,John Chapman,John Chapman,Dominique Mazier,Dominique Mazier,Patrick Froissard,Patrick Froissard +25 more
TL;DR: It is demonstrated that SR-BI significantly boosts hepatocyte permissiveness to P. falciparum, P. yoelii, and P. berghei entry and promotes parasite development, and the mechanistic basis of the CD81-dependent Plasmodium sporozoite invasion pathway is established.
Journal ArticleDOI
Temperature shift and host cell contact up-regulate sporozoite expression of Plasmodium falciparum genes involved in hepatocyte infection.
Anthony Siau,Olivier Silvie,Olivier Silvie,Jean-François Franetich,Jean-François Franetich,Samir Yalaoui,Samir Yalaoui,Carine Marinach,Carine Marinach,Laurent Hannoun,Geert-Jaan van Gemert,Adrian J. F. Luty,Emmanuel Bischoff,Peter H. David,Georges Snounou,Catherine Vaquero,Catherine Vaquero,Patrick Froissard,Patrick Froissard,Dominique Mazier,Dominique Mazier +20 more
TL;DR: The hypothesis that the shift from the mosquito to the mammalian host contributes to activate quiescent salivary gland sporozoites into a state of readiness for the hepatic stages of malaria is supported.
Journal ArticleDOI
A Plant-Derived Morphinan as a Novel Lead Compound Active against Malaria Liver Stages
Maëlle Carraz,Akino Jossang,Jean-François Franetich,Anthony Siau,Liliane Ciceron,Laurent Hannoun,Robert W. Sauerwein,François Frappier,Philippe Rasoanaivo,Georges Snounou,Dominique Mazier +10 more
TL;DR: A readily obtained semisynthetic derivative of a plant-derived compound, tazopsine, has been shown to be specifically active against the liver stage, but inactive against the blood forms of the malaria parasite.
Journal ArticleDOI
Whole-Transcriptome Analysis of Plasmodium falciparum Field Isolates: Identification of New Pathogenicity Factors
Anthony Siau,Fousseyni S. Touré,Odile Ouwe-Missi-Oukem-Boyer,Liliane Ciceron,Liliane Ciceron,Nassira Mahmoudi,Nassira Mahmoudi,Catherine Vaquero,Catherine Vaquero,Patrick Froissard,Patrick Froissard,Ulrick Bisvigou,Sylvie Bisser,Jean-Yves Coppée,Emmanuel Bischoff,Peter H. David,Dominique Mazier,Dominique Mazier +17 more
TL;DR: This is the first attempt to identify genes involved in parasite pathogenic mechanisms against human ECs, and the finding of Plasmodium apoptosis-linked pathogenicity factors (PALPFs) illuminates perspectives for novel therapeutic strategies against cerebral complications of malaria.