G
Germana Castelli
Researcher at Istituto Superiore di Sanità
Publications - 69
Citations - 2780
Germana Castelli is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Myeloid leukemia & Haematopoiesis. The author has an hindex of 26, co-authored 57 publications receiving 2147 citations. Previous affiliations of Germana Castelli include Thomas Jefferson University.
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Journal ArticleDOI
Isolation and characterization of CD146+ multipotent mesenchymal stromal cells.
Antonio Sorrentino,Manuela Ferracin,Germana Castelli,Mauro Biffoni,Giada Tomaselli,Marta Baiocchi,Alessandro Fatica,Massimo Negrini,Cesare Peschle,Mauro Valtieri +9 more
TL;DR: CD146(+) MSCs may represent a tool to explore the MSC-HSC cross-talk in an in vitro surrogate model for HSC "niches," and for regenerative therapy studies.
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Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells.
TL;DR: Deep-sequencing studies supporting the heterogeneity of lung tumors at cellular level, with sub-clones exhibiting different combinations of mutations, show the phenomenon of clonal evolution, thus supporting the occurrence of a temporal tumor heterogeneity.
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Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells
TL;DR: Experimental evidence suggests that colorectal cancers may derive from the malignant transformation of intestinal stem cells or of intestinal cells that acquire stem cell properties following malignant Transformation, and Colon cancer stem cells seem to be involved in tumor chemoresistance, radioresistance and relapse.
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miR-146 and miR-155: Two Key Modulators of Immune Response and Tumor Development.
TL;DR: The demonstration that miR-155 overexpression plays a key pathogenic role in some lymphomas and acute myeloid leukemias has led to the development of an antagomir-based approach as a new promising therapeutic strategy.
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Autocrine-paracrine VEGF loops potentiate the maturation of megakaryocytic precursors through Flt1 receptor.
Ida Casella,Tiziana Feccia,Tiziana Feccia,C Chelucci,C Chelucci,Paola Samoggia,Paola Samoggia,Germana Castelli,Germana Castelli,R Guerriero,R Guerriero,Isabella Parolini,Isabella Parolini,Eleonora Petrucci,Eleonora Petrucci,Elvira Pelosi,Elvira Pelosi,Ornella Morsilli,Ornella Morsilli,Marco Gabbianelli,Marco Gabbianelli,Ugo Testa,Ugo Testa,Cesare Peschle,Cesare Peschle +24 more
TL;DR: The results suggest that in the hematopoietic microenvironment an autocrine VEGF loop contributes to optimal Mk maturation through Flt1 and a paracrine loop involving V EGF release by E precursors may also operate.