Gil Kanfer

TL;DR: TAX1BP1 mediates clearance of a broad range of cytotoxic proteins indicating therapeutic potential in neurodegenerative diseases and is more specifically expressed in the brain compared to other autophagy receptors.

TL;DR: The AI-photoswitchable screening (AI-PS) as discussed by the authors was proposed to classify a broad range of mammalian subcellular morphologies, an approach largely unattainable with current methodologies at genome-wide scale.

TL;DR: In this paper, the VPS13D gene family was shown to regulate peroxisome biogenesis in HeLa cells and showed that VPS-13D loss leads to either partial or complete peroxideisome loss in several transformed cell lines and in fibroblasts derived from a VPS 13D mutation-carrying patient with recessive spinocerebellar ataxia.

TL;DR: A broad role is proposed for TAX1BP1 in the clearance of cytotoxic proteins, thus identifying a new mode of clearance of protein inclusions.

TL;DR: This approach, AI-Photoswitchable Screening (AI-PS) offers a novel screening platform capable of classifying a broad range of mammalian subcellular morphologies, an approach largely unattainable with current methodologies at genome-wide scale.