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Antonio Velayos-Baeza
Researcher at Wellcome Trust Centre for Human Genetics
Publications - 34
Citations - 1402
Antonio Velayos-Baeza is an academic researcher from Wellcome Trust Centre for Human Genetics. The author has contributed to research in topics: Chorea acanthocytosis & Dyslexia. The author has an hindex of 17, co-authored 33 publications receiving 1217 citations. Previous affiliations of Antonio Velayos-Baeza include Wellcome Trust & University of Oxford.
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Journal ArticleDOI
LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia
Clyde Francks,Shinji Maegawa,Juha Lauren,Brett S. Abrahams,Antonio Velayos-Baeza,Sarah E. Medland,Sarah E. Medland,Stefano Colella,Matthias Groszer,E. Z. McAuley,Tara M. Caffrey,Tõnis Timmusk,Priit Pruunsild,Indrek Koppel,Penelope A. Lind,N. Matsumoto-Itaba,Jérôme Nicod,Lan Xiong,Ridha Joober,Wolfgang Enard,B. Krinsky,Eiji Nanba,Anthony J. Richardson,Brien P. Riley,Nicholas G. Martin,Stephen M. Strittmatter,H.-J. Möller,Dan Rujescu,D. St Clair,Pierandrea Muglia,J. L. Roos,Simon E. Fisher,Richard Wade-Martins,Guy A. Rouleau,John F. Stein,Maria Karayiorgou,Daniel H. Geschwind,Jiannis Ragoussis,K. S. Kendler,Matti S. Airaksinen,Mitsuo Oshimura,Lynn E. DeLisi,Anthony P. Monaco +42 more
TL;DR: It is shown that LRRTM1 is expressed during the development of specific forebrain structures, and thus could influence neuronal differentiation and connectivity, and the first putative genetic effect on variability in human brain asymmetry is found.
Journal ArticleDOI
Analysis of the human VPS13 gene family.
TL;DR: Protein sequence comparisons suggest that intramolecular duplications have played an important role in the evolution of this gene family and three new genes encoding these CHAC-similar proteins are characterized.
Journal ArticleDOI
Chorein detection for the diagnosis of chorea-acanthocytosis
Carol Dobson-Stone,Antonio Velayos-Baeza,Lea A Filippone,Sarah K Westbury,Alexander Storch,Torsten Erdmann,Stephen J Wroe,Klaus L. Leenders,Anthony E. Lang,Maria Teresa Dotti,Antonio Federico,Saidi A Mohiddin,Lameh Fananapazir,Geoff Daniels,Adrian Danek,Anthony P. Monaco +15 more
TL;DR: Chorea‐acanthocytosis is a severe, neurodegenerative disorder that shares clinical features with Huntington's disease and McLeod syndrome, and expression of chorein is found in all human cells analyzed, but chorein expression was absent or noticeably reduced in ChAc patient cells, but not McLeod Syndrome and Huntington's Disease cells.
Journal ArticleDOI
Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility.
Wondwossen M Yeshaw,Marianne van der Zwaag,Francesco Pinto,Liza L. Lahaye,Anita I. E. Faber,Rubén Gómez-Sánchez,Amalia M. Dolga,Conor Poland,Anthony P. Monaco,Sven C.D. van IJzendoorn,Nicola A. Grzeschik,Antonio Velayos-Baeza,Ody C. M. Sibon +12 more
TL;DR: It is demonstrated that VPS13A is a peripheral membrane protein, associated with mitochondria, the endoplasmic reticulum and lipid droplets, and required for lipid transfer required for mitochondria and lipid Droplet related processes.
Journal ArticleDOI
The dyslexia-associated gene KIAA0319 encodes highly N- and O-glycosylated plasma membrane and secreted isoforms
TL;DR: Over-expressed constructs containing the main form and two alternative variants of KIAA0319 are shown to be a type I plasma membrane protein, a topology consistent with its proposed function in neuronal migration, and suggest that KIAa0319 could be involved not only in cell-cell interactions, but also in signalling.