Journal ArticleDOI
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain
Shireen A. Sarraf,Hetal V. Shah,Gil Kanfer,Alicia M. Pickrell,Lynne A. Holtzclaw,Michael E. Ward,Richard J. Youle,Richard J. Youle +7 more
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TLDR
TAX1BP1 mediates clearance of a broad range of cytotoxic proteins indicating therapeutic potential in neurodegenerative diseases and is more specifically expressed in the brain compared to other autophagy receptors.About:
This article is published in Molecular Cell.The article was published on 2020-12-03. It has received 62 citations till now. The article focuses on the topics: Proteotoxicity & Autophagy.read more
Citations
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Autophagy in major human diseases
Daniel J. Klionsky,Giulia Petroni,Ravi K. Amaravadi,Eric H. Baehrecke,Andrea Ballabio,Andrea Ballabio,Patricia Boya,José Manuel Bravo-San Pedro,Ken Cadwell,Francesco Cecconi,Francesco Cecconi,Augustine M.K. Choi,Augustine M.K. Choi,Mary E. Choi,Mary E. Choi,Charleen T. Chu,Patrice Codogno,Patrice Codogno,María Isabel Colombo,Ana Maria Cuervo,Vojo Deretic,Ivan Dikic,Zvulun Elazar,Eeva-Liisa Eskelinen,Gian Maria Fimia,David A. Gewirtz,Douglas R. Green,Malene Hansen,Marja Jäättelä,Terje Johansen,Gábor Juhász,Vassiliki Karantza,Claudine Kraft,Guido Kroemer,Nicholas T. Ktistakis,Sharad Kumar,Sharad Kumar,Carlos López-Otín,Kay F. Macleod,Frank Madeo,Jennifer Martinez,Alicia Meléndez,Alicia Meléndez,Noboru Mizushima,Christian Münz,Josef M. Penninger,Josef M. Penninger,Rushika M. Perera,Mauro Piacentini,Mauro Piacentini,Fulvio Reggiori,David C. Rubinsztein,Kevin M. Ryan,Junichi Sadoshima,Laura Santambrogio,Luca Scorrano,Hans-Uwe Simon,Hans-Uwe Simon,Anna Katharina Simon,Anne Simonsen,Anne Simonsen,Alexandra Stolz,Nektarios Tavernarakis,Nektarios Tavernarakis,Sharon A. Tooze,Tamotsu Yoshimori,Junying Yuan,Junying Yuan,Zhenyu Yue,Qing Zhong,Lorenzo Galluzzi,Federico Pietrocola +71 more
TL;DR: In this paper, preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
Journal ArticleDOI
The different autophagy degradation pathways and neurodegeneration
Angeleen Fleming,Mathieu Bourdenx,M Fujimaki,Cansu Karabiyik,Gregory J. Krause,Ana Lopez,Adrián Martín-Segura,Claudia Puri,Aurora Scrivo,John Skidmore,Sung Min Son,Eleanna Stamatakou,Lidia Wrobel,Ye Zhu,Ana Maria Cuervo,David C. Rubinsztein +15 more
TL;DR: The term autophagy encompasses different pathways that route cytoplasmic material to lysosomes for degradation and includes macroautophagy, chaperone-mediated autophathy, and microautophathy as discussed by the authors .
Journal ArticleDOI
A guide to the regulation of selective autophagy receptors.
TL;DR: This work highlights the four most prominent protein modifications – phosphorylation, ubiquitination, acetylation and oligomerisation – that are essential for autophagy receptor recruitment, function and turnover.
Journal ArticleDOI
Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation.
Eleonora Turco,Adriana Savova,Flora Gere,Luca Ferrari,Julia Romanov,Martina Schuschnig,Sascha Martens +6 more
TL;DR: In this paper, the roles of the human cargo receptors p62/SQSTM1, NBR1 and TAX1BP1 in the selective autophagy of ubiquitinated substrates were defined.
Journal ArticleDOI
Autophagy in the diabetic heart: A potential pharmacotherapeutic target in diabetic cardiomyopathy.
Saikat Dewanjee,Jayalakshmi Vallamkondu,Rajkumar Singh Kalra,Albin John,P. Hemachandra Reddy,Ramesh Kandimalla +5 more
TL;DR: In this article, the role of autophagy and its adaptations in the diabetic heart was assessed and the potential pharmacotherapeutic strategies towards targeting autophagia were discussed.
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