G
Gilberto Velho
Researcher at University of Paris
Publications - 180
Citations - 12035
Gilberto Velho is an academic researcher from University of Paris. The author has contributed to research in topics: Diabetes mellitus & Type 2 diabetes. The author has an hindex of 53, co-authored 172 publications receiving 11307 citations. Previous affiliations of Gilberto Velho include University of Rennes & Pierre-and-Marie-Curie University.
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Journal ArticleDOI
Familial Hyperglycemia Due to Mutations in Glucokinase -- Definition of a Subtype of Diabetes Mellitus
Philippe Froguel,Habib Zouali,Nathalie Vionnet,Gilberto Velho,M Vaxillaire,F. Sun,Suzanne Lesage,Markus Stoffel,Jun Takeda,Philippe Passa +9 more
TL;DR: Mutations in glucokinase are the primary cause of hyperglycemia in a substantial fraction of French patients with maturity-onset diabetes of the young and result in a relatively mild form of NIDDM that can be diagnosed in childhood.
Journal ArticleDOI
Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus
Nathalie Vionnet,Markus Stoffel,J. Takeda,K. Yasuda,Graeme I. Bell,Habib Zouali,Suzanne Lesage,Gilberto Velho,F. Iris,Ph. Passa,Philippe Froguel,David M. Cohen +11 more
TL;DR: The identification of a nonsense mutation in the gene encoding glucokinase and its linkage with early-onset diabetes in one family is reported, the first evidence implicating a mutation in a gene involved in glucose metabolism in the pathogenesis of NIDDM.
Journal ArticleDOI
Close Linkage of Glucokinase Locus on Chromosome 7p to Early-Onset Non-Insulin-Dependent Diabetes Mellitus
Philippe Froguel,Martine Vaxillaire,F. Sun,Gilberto Velho,Habib Zouali,M. O. Butel,Suzanne Lesage,Nathalie Vionnet,Karine Clément,Françoise Fougerousse,Y. Tanizawa,Jean Weissenbach,Jacques S. Beckmann,G. M. Lathrop,Ph. Passa,M. A. Permutt,David M. Cohen +16 more
TL;DR: In this article, a linkage between the glucokinase locus on chromosome 7p and diabetes in 16 French families with maturity-onset diabetes of the young, a form of NIDDM characterized by monogenic autosomal dominant transmission and early age of onset.
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Clinical spectrum associated with hepatocyte nuclear factor-1β mutations
Christine Bellanné-Chantelot,Dominique Chauveau,Jean-François Gautier,Danièle Dubois-Laforgue,Séverine Clauin,Sandrine Beaufils,Jean-Marie Wilhelm,Christian Boitard,Laure-Hélène Noël,Gilberto Velho,José Timsit +10 more
TL;DR: Detailed phenotypic analysis underlines the systemic spectrum of the disease and its wide variability, leading to different modes of presentation, and confirms that MODY5 may occur because of de novo mutation in HNF-1.
Journal ArticleDOI
Study and development of multilayer needle-type enzyme-based glucose microsensors
Robert Sternberg,Marie-Bernadette Barrau,Laurent Gangiotti,Daniel R. Thévenot,Dilbir S. Bindra,George S. Wilson,Gilberto Velho,Philippe Froguel,Gérard Reach +8 more
TL;DR: When implanted subcutaneously in anaesthetized rats, sensor responses correlated correctly with blood glucose concentration but presented sensitivity coefficients significantly different to those determined in vitro: a 2 point calibration procedure was found necessary for in vivo experiments.