G
Giorgio Marotta
Researcher at Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Publications - 81
Citations - 2579
Giorgio Marotta is an academic researcher from Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico. The author has contributed to research in topics: Parkinson's disease & Dopaminergic. The author has an hindex of 23, co-authored 77 publications receiving 2105 citations. Previous affiliations of Giorgio Marotta include University of Milan & University of Pisa.
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Journal ArticleDOI
Survival and dementia in GBA-associated Parkinson's disease: The mutation matters.
Roberto Cilia,Sara Tunesi,Giorgio Marotta,Emanuele Cereda,Chiara Siri,Silvana Tesei,Anna Zecchinelli,Margherita Canesi,Claudio Mariani,Nicoletta Meucci,Giorgio Sacilotto,Michela Zini,Michela Barichella,Corrado Magnani,Stefano Duga,Rosanna Asselta,Giulia Soldà,Agostino Seresini,Manuela Seia,Gianni Pezzoli,Stefano Goldwurm +20 more
TL;DR: The objective of this work was to investigate survival, dementia, and genotype‐phenotype correlations in patients with Parkinson's disease with and without mutations on the glucocerebrosidase gene (GBA).
Journal ArticleDOI
Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers
Niccolo E. Mencacci,Niccolo E. Mencacci,Ioannis U. Isaias,Martin M. Reich,Christos Ganos,Christos Ganos,Vincent Plagnol,James M. Polke,Jose Bras,Joshua Hersheson,Maria Stamelou,Maria Stamelou,Maria Stamelou,Alan M. Pittman,Alastair J. Noyce,Kin Y. Mok,Thomas Opladen,Erdmute Kunstmann,Sybille Hodecker,Alexander Münchau,Jens Volkmann,Samuel Samnick,Katie Sidle,Tina Nanji,Mary G. Sweeney,Henry Houlden,Amit Batla,Anna Zecchinelli,Gianni Pezzoli,Giorgio Marotta,Andrew J. Lees,Paulo Alegria,Paul Krack,Florence Cormier-Dequaire,Suzanne Lesage,Alexis Brice,Peter Heutink,Thomas Gasser,Steven J. Lubbe,Huw R. Morris,Pille Taba,Sulev Kõks,Elisa Majounie,J. Raphael Gibbs,Andrew B. Singleton,John Hardy,Stephan Klebe,Kailash P. Bhatia,Nicholas W. Wood +48 more
TL;DR: Mutations in the gene encoding the dopamine-synthetic enzyme GTP cyclohydrolase-1 (GCH1) cause DOPA-responsive dystonia and are associated with an increased risk of Parkinson's disease in both DRD pedigrees and in patients with Parkinson's Disease but without a family history of DRD.
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Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling
Roberto Cilia,Ji Hyun Ko,Sang Soo Cho,Thilo van Eimeren,Giorgio Marotta,Giovanna Pellecchia,Gianni Pezzoli,Angelo Antonini,Antonio P. Strafella +8 more
TL;DR: The post-hoc analysis displayed a reduced tracer binding in the ventral striatum of PD patients with PG compared to PD controls, possibly reflecting either a reduction of mesolimbic projections or, alternatively, a lower membrane DAT expression on presynaptic terminals.
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Functional Abnormalities Underlying Pathological Gambling in Parkinson Disease
Roberto Cilia,Chiara Siri,Giorgio Marotta,Ioannis U. Isaias,Danilo De Gaspari,Margherita Canesi,Gianni Pezzoli,Angelo Antonini +7 more
TL;DR: It is found that PD patients with PG have abnormal resting state dysfunction of the mesocorticolimbic network possibly associated with a drug-induced overstimulation of relatively preserved reward-related neuronal systems, which supports the concept that PG is a "behavioral" addictive disorder.
Journal ArticleDOI
Neuromelanin Imaging and Dopaminergic Loss in Parkinson's Disease
Ioannis U. Isaias,Paula Trujillo,Paul Summers,Giorgio Marotta,Luca Mainardi,Gianni Pezzoli,Luigi Zecca,Antonella Costa +7 more
TL;DR: Neuromelanin-MRI can be used for quantifying substantia nigra pathology in PD where it closely correlates with dopaminergic striatal innervation loss, and the best predictor of DAT reduction was the volume of the substantia Nigra.