Giuseppe Paolisso

TL;DR: The results support the hypothesis that the genetic background favoring cardiovascular diseases is detrimental to longevity and suggest that the centenarian genetic background may be useful for investigating genetic key components of age‐associated diseases that are characterized by a multifactorial etiology.

TL;DR: The data suggest that reduction of proteasome activity promotes vascular cell senescence, thereby contributing to the pathogenesis of human atherosclerosis.

TL;DR: In older adults with type 2 diabetes, long-term effects of an MPD regimen are associated with a significant decline of renal function, proteinuria, low-grade inflammation, and oxidative stress without a change in fat-free mass.

TL;DR: Evidence that LVH in hypertensive patients is associated with a worsening in nonoxidative glucose metabolism is provided, independently of age, body weight, systolic blood pressure and plasma catechola‐mines levels.

TL;DR: The present study investigating the effect of a combined insulin + glipizide treatment on the metabolic control and insulin requirements in ten non-obese Type-II diabetic patients with recent secondary failure to sulfonylureas and characterizing the relative contributions of changes in endogenous insulin secretion (C-peptide response) and insulin sensitivity to this effect.