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Giuseppe Paolisso
Researcher at Seconda Università degli Studi di Napoli
Publications - 518
Citations - 36557
Giuseppe Paolisso is an academic researcher from Seconda Università degli Studi di Napoli. The author has contributed to research in topics: Insulin & Diabetes mellitus. The author has an hindex of 85, co-authored 479 publications receiving 33028 citations. Previous affiliations of Giuseppe Paolisso include National Institutes of Health & University of Udine.
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Journal ArticleDOI
New insight in molecular mechanisms regulating SIRT6 expression in diabetes: Hyperglycaemia effects on SIRT6 DNA methylation.
Lucia Scisciola,Maria Rosaria Rizzo,Raffaele Marfella,Vittoria Cataldo,Rosaria Anna Fontanella,Eugenio Boccalone,Giuseppe Paolisso,Michelangela Barbieri +7 more
TL;DR: The involvement of epigenetic mechanisms in regulating SIRT6 expression and the effect of hyperglycaemia on DNA methylation and Sirt6 expression has been evaluated in human aortic endothelial cells exposed to high glucose.
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MicroRNAs modulation and clinical outcomes at 1 year of follow-up in obese patients with pre-diabetes treated with metformin vs. placebo
Celestino Sardu,Maria Consiglia Trotta,Gorizio Pieretti,Gianluca Gatta,Giuseppe A. Ferraro,Giovanni Francesco Nicoletti,Nunzia D' Onofrio,Maria Luisa Balestrieri,Michele D' Amico,Angela Marie Abbatecola,Franca Ferraraccio,Iacopo Panarese,Giuseppe Paolisso,Raffaele Marfella +13 more
TL;DR: In this article, the authors evaluated miRs expression and cardiovascular function in obese pre-diabetics assigned to metformin therapy vs. placebo vs. normo-glycemics at 12 months of follow-up.
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Sodium-Glucose Cotransporter-2 (SGLT2) expression in diabetic and non-diabetic failing human cardiomyocytes.
Raffaele Marfella,Lucia Scisciola,Nunzia D'Onofrio,Ciro Maiello,Maria Consiglia Trotta,Celestino Sardu,Iacopo Panarese,Franca Ferraraccio,Annalisa Capuano,Michelangela Barbieri,Maria Luisa Balestrieri,Claudio Napoli,Giuseppe Paolisso +12 more
TL;DR: The hypothesis of SGLT2i-mediated impact on metabolic pathways within cardiomyocytes supports the hypothesis that metabolic disorders linked to diabetes may lead promptly to upregulation of S GLT2 levels in humanCardiomyocyte.
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Microbiota thrombus colonization may influence athero-thrombosis in hyperglycemic patients with ST segment elevation myocardialinfarction (STEMI). Marianella study.
Celestino Sardu,Maria Consiglia Trotta,Biagio Santella,Nunzia D'Onofrio,Michelangela Barbieri,Maria Rosaria Rizzo,Ferdinando Carlo Sasso,Lucia Scisciola,Fabrizio Turriziani,Michele Torella,Michele Portoghese,Francesco Loreni,Simone Mureddu,Maria Antonietta Lepore,Massimiliano Galdiero,Gianluigi Franci,Veronica Folliero,Arianna Petrillo,Lara Boatti,Fabio Minicucci,Ciro Mauro,Paolo Calabrò,Marisa De Feo,Maria Luisa Balestrieri,Danilo Ercolini,Michele D'Amico,Giuseppe Paolisso,Marilena Galdiero,Raffaele Marfella +28 more
TL;DR: In this paper, the authors examined the association of the coronary thrombus microbiota and relative metabolites with major adverse cardiovascular events (MACE) in hyperglycemic patients with ST segment elevation myocardial infarction (STEMI).
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Diabetes-related quality of life is enhanced by glycaemic improvement in older people
Angela Marie Abbatecola,Liana Spazzafumo,Paolo Fabbietti,Roberto Testa,R. A. Rabini,Anna Rita Bonfigli,Andrea Corsonello,Fabrizia Lattanzio,Giuseppe Paolisso +8 more
TL;DR: To investigate the validity and reliability of the Audit of Diabetes‐Dependent Quality of Life instrument in older Italians with diabetes and to test the association of diabetes‐related quality of life with glycaemic control over time.