G
Gordon L. Amidon
Researcher at University of Michigan
Publications - 469
Citations - 38521
Gordon L. Amidon is an academic researcher from University of Michigan. The author has contributed to research in topics: Intestinal absorption & Prodrug. The author has an hindex of 86, co-authored 466 publications receiving 35880 citations. Previous affiliations of Gordon L. Amidon include ETH Zurich & Merck & Co..
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Dissolution and solubility behavior of fenofibrate in sodium lauryl sulfate solutions.
TL;DR: The much lower enhancement in dissolution of fenofibrate compared to its enhancement in solubility in surfactant solutions appears to be consistent with the contribution to the total transport due to enhanced micellar solubilization as well as a large decrease in the diffusivity of the drug-loaded micelle.
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The effect of amiloride on the in vivo effective permeability of amoxicillin in human jejunum: experience from a regional perfusion technique.
Hans Lennernäs,Lars Knutson,T. Knutson,Ajaz S. Hussain,Lawrence J. Lesko,T. Salmonson,Gordon L. Amidon +6 more
TL;DR: The purpose of this human intestinal perfusion study (in vivo) was to determine the effective in vivo jejunal permeability (P(eff) of amoxicillin and to classify it according to the Biopharmaceutics Classification System (BCS).
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Beta Cyclodextrins Enhance Adenoviral-Mediated Gene Delivery to the Intestine
TL;DR: These cyclodextrin formulations can be of value in gene transfer to cells and tissues in which adenoviral infection is limited due to a lack of fiber and αv integrin receptors.
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The fraction dose absorbed, in humans, and high jejunal human permeability relationship.
TL;DR: Setting the adequate standard for the low/high permeability class boundary, the different experimental methods for the permeability measurement, and segmental-dependent permeability throughout the human intestine due to different mechanisms are some of the main points that are discussed.
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Mechanistic analysis of solute transport in an in vitro physiological two-phase dissolution apparatus.
TL;DR: The theory and derivation of the analysis is presented, it is compared with a recent kinetic approach, and its effectiveness in predicting in vitro partitioning profiles of three BCS II weak acids in four different in vitro two‐phase dissolution apparatuses is demonstrated.