Gordon L. Amidon

TL;DR: The results of GastroPlus simulations indicate that the dissolution rate of BCS class III drugs could be prolonged to the point where dissolution, rather than permeability, would control the overall absorption.

TL;DR: An approach is developed by which the solubility of an organic compound in mixed solvents may be estimated by using an expression for the excess Gibbs free energy of mixing for multicomponent solvent systems to obtain parameters characteristic of the interaction between thesolvents.

TL;DR: The data suggest that P- gp plays a minimal role in the in vivo intestinal absorption process of verapamil with high water solubility and high membrane permeability, and does not undermine the importance of P-gp in oral drug bioavailability, drug disposition from the liver, drug efflux from the blood-brain barrier, and drug-drug interaction.

TL;DR: A dosage regimen involving reduced doses of both drugs, with an interval between doses of approximately 12 hr, is proposed for patients with severe renal failure.

TL;DR: Dipeptide monoester prodrugs of floxuridine suggest their potential for increased oral uptake, delayed enzymatic bioconversion and enhanced resistance to metabolism to 5-fluorouracil, as well as enhanced uptake and cytotoxic activity in cancer cells, attributes that would facilitate prolonged systemic circulation for enhanced therapeutic action.